A5014462631- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Synthesis and biological activity
- Molecular Biology Techniques and Applications
- Oral microbiology and periodontitis research
- Advanced biosensing and bioanalysis techniques
- Lymphoma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- RNA and protein synthesis mechanisms
- Phytochemistry Medicinal Plant Applications
- Kruppel-like factors research
- Piperaceae Chemical and Biological Studies
- Salivary Gland Disorders and Functions
- Phytochemistry and Bioactivity Studies
- Vitamin D Research Studies
- Antioxidant Activity and Oxidative Stress
Hospital Sungai Buloh
2020-2024
Universiti Teknologi MARA
2012-2024
Universiti Sains Malaysia
2023
The University of Melbourne
2021
University of Malaya
2013
Universiti Teknologi MARA System
2011
Hypermethylation in promoter regions of genes might lead to altered gene functions and result malignant cellular transformation. Thus, biomarker identification for hypermethylated would be very useful early diagnosis, prognosis, therapeutic treatment oral squamous cell carcinoma (OSCC). The objectives this study were screen validate differentially OSCC correlate the hypermethylation-induced with demographic, clinocopathological characteristics survival rate OSCC.DNA methylation profiling was...
Matrix metalloproteinase 13 ( MMP13 ) plays a central role in the MMP activation cascade that enables degradation of extracellular matrix and basement membranes, it is identified as potential driver oral carcinogenesis. Therefore, this study aims to determine copy number, mRNA, protein expression squamous cell carcinoma (OSCC) associate these expressions with clinicopathological parameters. Copy analysis were determined using real-time quantitative PCR immunohistochemistry methods OSCC...
Objectives . To estimate the impact of ellagic acid (EA) towards healing tooth socket in diabetic animals, after extraction. Methods Twenty-four Sprague Dawley male rats weighing 250–300 g were selected for this study. All animals intraperitoneally injected with 45 mg/kg (b.w.) freshly prepared streptozotocin (STZ), to induce mellitus. Then, anesthetized, and upper left central incisor was extracted whole sockets filled Rosuvastatin (RSV). The separated into three groups, comprising 8 each....
Background: Oral cancer has become one of the most prevalent cancers worldwide and human Papillomavirus is risk factors for developing oral cancer. For this study HPV18 was chosen as it high HPV types may lead to carcinogenesis. However, prevalence infection in Squamous Cell Carcinoma Malaysia remains unclear. Objective: This aimed investigate viral load DNA OSCC potentially malignant lesions using saliva samples. Materials Methods: Genomic DNAs thirty samples normal subjects compromised 16...
Promoter hypermethylation is a frequent epigenetic mechanism for gene transcription repression in cancer and one of the hallmarks disease. Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) contributes to cell contact-mediated communication. Dysregulation promoter methylation has been reported various cancers.The objectives this study were investigate CELSR3 level oral squamous carcinomas (OSCCs) using methylation-sensitive high-resolution melting analysis (MS-HRM) correlate with patient...
Promoter hypermethylation leads to altered gene functions and may result in malignant cellular transformation. Thus, identification of biomarkers for hypermethylated genes could be useful diagnosis, prognosis, therapeutic treatment oral squamous cell carcinoma (OSCC).To screen with a microarray approach validate selected the methylation-specific polymerase chain reaction (MSPCR).Genome-wide analysis normal mucosa OSCC tissues was conducted using Illumina methylation microarray. The specified...
Background and Objectives: Pfu DNA polymerase is an enzyme that exhibits the lowest error rate in 3´ to 5´ exonucle- ase (proofreading) activity during synthesis Polymerase Chain Reactions (PCRs). This study was aimed express purify a bacterial expression system under simple purification method. Materials Methods: gene sequence, derived from Pyrocuccus furiosus (Pfu) genomic DNA, cloned overexpressed E. coli BL21 (DE3) pLysS. Upon overexpression, lysate containing heated at 94°C for 5...
In most tumours including Oral squamous cell carcinoma (SCC), acquisition of genetic instability is an essential stepduring carcinogenesis that involves generalized increased rate errors during DNA replication, and defective repair ofDNA. The genomic change results in numerical structural chromosomal alterations, particularly chromosomes 3,9, 11 17. Chromosome 17 abnormality was chosen my study because it shown strong correlation with neoplasticdevelopment progression. study, twenty SCC...
Evidence suggests heterocyclic rings as the essential component of various available chemotherapeutics. Present study was aimed to carry out molecular docking, synthesis, characterization and response new camptothecin derivatives (NCDs) towards OSCC cell lines. To achieve aim study, were designed perform docking against target protein Human DNA Topoisomerase-1 (1T8I). Molecules 2 3 with high scores subjected synthesis. In current investigation, NCDs synthesized by cyclization imino analogue...
Oral squamous cell carcinoma (OSCC), a major oral cancer, significantly challenges treatments and impacts patient quality of life; current therapies often cause severe side effects, highlighting the urgent need for gentler alternatives. Rice stands as one primary cereal grains providing daily caloric intake more than half global population. Extensive research has demonstrated significant health benefits derived from rice, attributed to its abundance bioactive compounds. This study endeavours...
Dillapiole is one of the major compounds in Peperomia pellucida. exerts cytotoxicity effect on several cancer cells such as breast and colon with a minimal normal cells. However, its cancers head neck region remains ambiguous. Therefore, current study, dillapiole human nasal squamous cell carcinoma, RPMI 2650 underlying mechanism were investigated. Normal gingival fibroblast, HGnF was used comparison. Cisplatin untreated positive negative controls, respectively. Cell determined using WST-1...
Objectives: The aim of the study was to evaluate year one dental students for their score decayed, missing, filled teeth (DMFT), total salivary protein, and unstimulated stimulated flow rate secretions. In addition, correlations between DMFT index with parameters were also elucidated in our study. Methods: Fifty-seven selected study, informed consents obtained prior Intraoral examination specifically scoring performed. Both proteins saliva measured using Bicinchoninic acid protein assay,...
Oral squamous cell carcinoma (OSCC) developed from mucosal lining of oral cavity is ranked as 6th most common cancer worldwide. Adverse effects available anticancer agents intended present work to carry out the synthesis, characterization and evaluation new quinoline analogues (NQA) against OSCC lines. In study, substituted (1) was treated with ethyl chloroacetate offer ester derivative (2), which on treatment hydrazine hydrate yielded hydrazide (3), cyclized into oxadiazole (4) when...