A5100630345- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Antimicrobial Resistance in Staphylococcus
- Growth Hormone and Insulin-like Growth Factors
- Renal Transplantation Outcomes and Treatments
- Pituitary Gland Disorders and Treatments
- RNA modifications and cancer
- Diabetes Treatment and Management
- Epilepsy research and treatment
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Surgical Treatments
- Gut microbiota and health
- RNA Research and Splicing
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- Pneumonia and Respiratory Infections
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- Colorectal and Anal Carcinomas
- Tuberous Sclerosis Complex Research
National Defense Medical Center
2011-2025
Tri-Service General Hospital
2019-2025
Tongji University
2024
Xiamen University
2021-2024
Taiwan Nurses Association
2024
Peking University First Hospital
2016-2022
Peking University
2016-2022
Zhuhai People's Hospital
2022
Fudan University
2016
Yangzhou University
2013
The optimal use of vancomycin in the elderly requires information about drug's pharmacokinetics and influence various factors on disposition. However, because sampling restrictions, it is often difficult to perform traditional pharmacokinetic studies patients. This study was conducted estimate population Chinese geriatric patients (age ≥ 65 years) with pulmonary infections explore clinical application this for dose individualization. steady-state trough concentrations were retrospectively...
The Pharmacokinetics of Methotrexate (MTX) has been reported to show significant intersubject variability. MTX is metabolized by SHMT1 and transported OATP1B1 OATP1B3 both which genetic polymorphisms. non-genetic factors may influence the pharmacokinetics MTX.This study aimed determine pharmacokinetic parameters in Chinese patients investigate effect various variants OATP1B1, on MTX's pharmacokinetics.MTX concentration clinical characteristics data were collected from 71 rheumatoid arthritis...
Vancomycin remains a mainstay of the treatment Gram-positive bacterial infections. It is crucial to accurately determine vancomycin serum concentration for adequate dose adjustment.To evaluate precision and accuracy commercial assay techniques assess comparability detection methods in Chinese laboratories.Human samples spiked with known concentrations were provided laboratories participating external quality assessment scheme (EQAS). Assay included chemiluminescence, enzyme immunoassay (EIA)...
Monohydroxycarbamazepine (MHD, 10-hydroxy-carbamazepine) is the main active metabolite of oxcarbazepine (OXC). The present study aims to investigate relationship between plasma and saliva concentrations MHD in Chinese children with epilepsy.Plasma samples were collected levels measured by high-performance liquid chromatography system. Linear regression analysis was conducted dose OXC concentrations, concentrations. Student's t-test used for unpaired data. A one-way variance analyzing...
Oxcarbazepine (OXC) is a widely used antiepileptic drug whose effect mainly depends on its active metabolite 10-hydroxycarbazepine (MHD). This study established population pharmacokinetic (PPK) model of MHD in Chinese children with epilepsy and conducted dosage simulation order to provide support for individualized OXC treatment.Ninety-one plasma sampling points from 88 paediatric patients were retrospective collected. concentrations detected, patients' clinical data recorded. PPK analysis...
Abstract The key N 6 methyladenosine (m A) RNA methylation regulator is associated with multiple tumour progression. However, the m A‐associated regulators that influence non‐small cell lung cancer (NSCLC) development have not been fully clarified. A expression pattern of NSCLC patients from Cancer Genome Atlas (TCGA) dataset was identified. Aberrations m6A modulators are related to via cBioPortal database. Furthermore, we found IGF2BP2, IGF2BP3, HNRNPA2B1, and FTO significantly correlated...
Some studies have suggested heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) to be a promoter in cancer development. Nonetheless, no detailed pan-cancer investigation has been reported. Thus, this study explored the possible oncogenic role of HNRNPA2B1, such as its expression levels, gene alteration, protein-protein interaction network, immune infiltration, and prognostic value different types using The Cancer Genome Atlas web platform. Many exhibit HNRNPA2B1 overexpression, which...
Background and Objectives: Although human papillomavirus (HPV) is a major etiology of cervical anogenital cancers, whether it associated with colorectal carcinogenesis yet undetermined. Materials Methods: The longitudinal association HPV infection cancer (CRC) was evaluated using 2000-2013 data from nationwide Taiwanese claims database. In this retrospective cohort study, 358 patients primary diagnoses (HPV-infected cohort) 1432 without such diagnosis (HPV-uninfected were recruited between...
Abstract Background Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development gynecological tumors. However, its immune-related carcinogenic mechanism other tumors remains unclear. Objective The aim this study was identify PTK6 as a novel prognostic biomarker pan-cancer, especially lung adenocarcinoma (LUAD), which is correlated with immune infiltration, and clarify clinicopathological significance. Methods value relevance were investigated by...
The aims of this study were to investigate the population pharmacokinetic (PPK) characteristics tacrolimus in Chinese children with nephrotic syndrome and apply it clinical practice.A total 137 concentrations from 61 patients collected routine therapeutic drug monitoring data between 2011 2018. Population modeling was performed nonlinear mixed-effects model (NONMEM) program, using a one-compartment first-order absorption elimination. mean estimate values clearance (CL/F) volume distribution...
Hepatitis B virus (HBV) has a 3.2 kb circular DNA genome. It employs four promoters in conjunction with single polyadenylation signal to generate 3.5, 2.4, 2.1 and 0.7 co-terminal RNAs. The 3.5 RNA is subdivided into the precore for e-antigen expression pregenomic genome replication. When introduced genotype A clone, several core promoter mutations markedly enhanced HBV replication, but suppressed through up-regulation of at expense RNA. In this study, we found such also diminished envelope...
Patients with colorectal cancer (CRC) undergo surgery, as well perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor-node- metastasis (TNM) staging system. However, treatment responses and prognostic outcomes of patients within same stage vary markedly. The potential use novel biomarkers can improve prognostication shared decision making before implementation into certain therapies.To investigate whether SUMF2, ADAMTS5, PXDN methylation status could be associated...