Estrogen has the potential to influence brain physiology implicated in dementia pathogenesis. Hormone replacement therapy (HRT) might be expected risk of dementia. Observational data indicated that HRT was associated with reductions risk, but experimental evidence demonstrates increases incidence To determine effect on dementia, a retrospective cohort study performed using nationwide claims dataset Taiwan.A population-based longitudinal from Longitudinal Health Insurance Database Taiwan. A...

Abstract The incidence of breast and genital tract cancers is increasing among Taiwanese women, but the age specificity histopathological features these have not been determined. We used a descriptive epidemiological method data from Taiwan Cancer Registry (1979–2007) to examine secular trends in age‐specific incidences female cancer, three major subtypes cancers. Age‐specific rates United States (1978–2002) were as an external reference, all malignancies malignant brain tumors internal...

Abstract Background Taiwan has one of the highest incidences upper tract urothelial cancer (UTUC) worldwide, especially in women; however, no nationwide, long‐term follow‐up study evaluated this. Methods We investigated incidence UTUC using data from national population‐based Cancer Registry database (1985–2019). divided birth cohort into nine 5‐year age groups and calculated age‐specific for these according to corresponding years. Results The average annual percent change renal pelvis 1985...

Although male breast cancer (MBC) is globally rare, its incidence significantly increased from 1990 to 2017. The aim of this study was examine variations in the trends MBC between populations Taiwan and USA 1980 2019. Cancer Registry database Surveillance, Epidemiology, End Results (SEER) Program National Institute were used. age-standardized rate calculated using world standard population 2000. long-term age, time period, birth cohort effect on rates estimated SEER Age-Period-Cohort Web...

Results of studies regarding the potential link between acid suppressant use and dementia risk are inconsistent. This study aimed to evaluate association cumulative exposure histamine 2 receptor antagonists (H2RAs) proton pump inhibitors (PPIs) with in an Asian older cohort aged ≥65 years.Patients initiating H2RA (the user cohort, n = 21,449) or PPI 6584) those without prescription for non-user 1 January 2000 31 December 2005 a prior history were identified from Taiwan's National Health...

(1) Background: Colorectal cancer (CRC) is the third most common malignancy and second leading cause of deaths worldwide. It often diagnosed at advanced stages, with increasing incidence younger generation. CRC poses a heavy financial burden huge public health challenge nowadays. Lipoproteins serum lipids may have an influence on carcinogenesis by making oxidative stress, inflammation, insulin resistance. Dyslipidemia plays potential role in risk CRC. The purpose this study to use nationally...

Previous studies have indicated that HBV infection and T2DM are the factors increase risk of developing HCC. The experimental evidence has shown antiglycemic agents may reduce However, effect dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) on HCC in patients with chronic remains unclear. In this retrospective cohort study, we extracted from National Health Insurance Research Database (NHIRD) Taiwan. cases were divided into DPP-4 use non-use groups, according to whether they received...

Abstract The role of atopic dermatitis (AD) in the development colorectal cancer (CRC) has been a matter scientific debate with mixed results. We conducted nationwide cohort study to assess association between AD and risk CRC. Drawing on Taiwan's National Health Insurance Research Database, 46,703 patients (the cohort) 186,812 sex, age, index year-matched without non-AD were identified period 2000 2008. Follow-up time was calculated from date entry until occurrence first CRC diagnosis,...

To evaluate the safety of using fluoroquinolones in pediatric population Taiwan.Patients aged 0~18 years old with prescriptions ≥5 consecutive days during year 2000 to 2013 were selected from National Health Insurance Research Database, 4-time case number as controls. We evaluated patient's outcome after use by reviewing a newly diagnosis following collagen-associated adverse events International Classification Diseases, Ninth Revision, Clinical Modification codes, covering tendons rupture,...

In a country with high prevalence of cigarette smoking, betel chewing, and alcohol drinking, cancers the oral cavity, nasopharynx, larynx were fourth, twelfth seventeenth leading causes cancer death, respectively, for men in 2020. We analyzed patients head neck from 1980 to 2019 Taiwan Cancer Registration Database discussed annual average percent change, age period, birth cohort. Obvious period effects are seen oral, oropharyngeal, hypopharyngeal cancer; however, most significant effect was...

The safety of human papillomavirus (HPV) vaccines has been evaluated continuously in pre-licensure clinical trials, post-marketing surveillance systems, and observational studies. Most studies have found no significant association between serious adverse events HPV vaccination. However, these focused on Western populations; similar focusing Asian populations are insufficient. Our retrospective cohort study used the HPV-vaccination records junior high-school adolescent girls aged 12-15 years...

Background and Objectives: Although human papillomavirus (HPV) is a major etiology of cervical anogenital cancers, whether it associated with colorectal carcinogenesis yet undetermined. Materials Methods: The longitudinal association HPV infection cancer (CRC) was evaluated using 2000-2013 data from nationwide Taiwanese claims database. In this retrospective cohort study, 358 patients primary diagnoses (HPV-infected cohort) 1432 without such diagnosis (HPV-uninfected were recruited between...

Background: Thyroid cancer incidence has increased globally in recent decades, especially females, although its trends Taiwan have not been studied extensively. This study aimed to investigate changes female and possible causes of thyroid Taiwan. Methods: Using the Cancer Registry (TCR) Database, age-standardized rates, age-specific rates birth cohorts were calculated. Correlation between cohort fertility examined. Results: Taiwanese female, with age-adjusted per 100,000 people increasing...

We explored if the administration of fluoxetine, recognized for its potential in adipocyte browning, entails a differential risk coronary heart disease (CHD) comparison to other SSRI medications.

Gout is the most common form of inflammatory arthritis in adults. Even though a link between gouty and type 2 diabetes mellitus (T2DM) has been reported, there limited understanding association anti-inflammatory agent colchicine risk T2DM. This aim this study was to assess use T2DM an Asian cohort. A retrospective cohort conducted using National Health Insurance Research Database (NHIRD) Taiwan from 2000 2013. The cohorts comprised 3841 patients (the exposed cohort) 7682 not unexposed...

Chronic inflammation, a hallmark of gout, is implicated in the pathogenesis atherosclerosis. Thus, theory, gout can be expected to increase risk acute myocardial infarction (AMI). Yet, results from several epidemiological studies have been inconclusive. A retrospective cohort study was conducted using National Health Insurance Research Database Taiwan dated 2000 2013. The comprised 3581 patients with (the cohort) and 14,324 without non-gout cohort). primary outcome incidence AMI. To estimate...

Background Migraine is associated with a significant economic burden in W estern countries. However, there limited information regarding the impact of cost migraine A sia. Objectives To quantify and compare direct medical costs refractory ( RM ) other migraine, using health insurance claims data T aiwan. Methods retrospective matched case–control study was conducted utilizing from aiwan N ational H ealth I nsurance R esearch D atabase. cases were defined as patients at least 1 neurological...

Background Recent studies have raised concerns about the reduced efficacy of citalopram when used concurrently with proton pump inhibitors. The aim this study was to evaluate associations between clinical use and omeprazole risk sudden cardiac arrest (SCA) in an Asian population. Methods Results A retrospective cohort conducted using National Health Insurance Research Database Taiwan dated from 2000 2013. cohorts comprised 3882 patients alone, 31 090 405 concomitant (as exposed cohort), 141...