A5058875939- Lipid metabolism and disorders
- Estrogen and related hormone effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Clusterin in disease pathology
- Magnesium in Health and Disease
- Cancer Cells and Metastasis
- Regulation of Appetite and Obesity
- Cancer-related molecular mechanisms research
- Intestinal and Peritoneal Adhesions
- Cancer, Lipids, and Metabolism
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- PI3K/AKT/mTOR signaling in cancer
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Exercise and Physiological Responses
- Bioactive Compounds and Antitumor Agents
- Therapeutic Uses of Natural Elements
- Cancer, Hypoxia, and Metabolism
- Bariatric Surgery and Outcomes
- Pharmacology and Obesity Treatment
- Adipose Tissue and Metabolism
Dasman Diabetes Institute
2018-2024
Kuwait University
2015-2016
De novo and acquired resistance to endocrine-based therapies in breast cancer occurs parallel with epithelial mesenchymal transition (EMT), which is associated enhanced proliferative metastatic potential, poor clinical outcome. We have established several endocrine insensitive lines by shRNA-induced depletion of estrogen receptor (ER) transfection MCF7 cells. All these exhibit EMT. previously reported that brief exposure specifically ER- cells, extracellular alkaline pH, results cell...
Bariatric surgery is a well-established treatment for obesity and type 2 diabetes. Tirzepatide, dual GIP/GLP-1 receptor agonist, has emerged as promising therapy This study aimed to compare the effects of bariatric surgery, semaglutide (a GLP-1 agonist), tirzepatide in Sprague-Dawley rats fed high-fat diet.
In this clinical trial, we assessed the efficacy of magnesium (Mg) supplementation in hypomagnesemic type 2 diabetes patients restoring serum and intracellular Mg levels. The study had two coprimary end points: change level between baseline after 3 months supplementation. We compared with regard to lowering hemoglobin A1c (HbA1c), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), 8-isoprostane as secondary points.In an open-label 47 were administered 336 mg daily. At months, serum,...
Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 suggested regulate triglyceride metabolism and increased obesity diabetes. However, its diseases adolescents not well-studied. In this study, we tested the hypothesis positive association between plasma ANGPTL5, obesity, high sensitivity C-reactive protein (HsCRP) oxidized low-density lipoprotein (Ox-LDL) adolescents. Adolescents (N = 431; age 11-14 years)...
Background: Angiopoietin-like protein 8 (ANGPTL8) is known to regulate lipid metabolism and inflammation. It interacts with ANGPTL3 ANGPTL4 lipoprotein lipase (LPL) activity IKK modulate NF-κB activity. Further, a single nucleotide polymorphism (SNP) leading the ANGPTL8 R59W variant associates reduced low-density lipoprotein/high-density (LDL/HDL) increased fasting blood glucose (FBG) in Hispanic Arab individuals, respectively. In this study, we investigate impact of on inflammatory ANGPTL8....
Leucine-rich α-2 glycoprotein1 (LRG1) is a member of the leucine-rich repeat (LRR) family that implicated in multiple diseases, including cancer, aging, and heart failure, as well diabetes obesity. LRG1 plays key role diet-induced hepatosteatosis insulin resistance by mediating crosstalk between adipocytes hepatocytes. also promotes upregulating de novo lipogenesis liver suppressing fatty acid β-oxidation. In this study, we investigated association with obesity markers, leptin other...
Angiopoietin-like proteins (ANGPTLs) mediate many metabolic functions. We had recently reported increased plasma levels of ANGPTL8 in obese adults Arab ethnicity. However, data on adolescent obesity is lacking. population characterized by a rapid transition, due to sudden wealth seen the post-oil era, lifestyle, food habits and extent physical activity. adopted cross-sectional study adolescents from Kuwait examine role obesity. The cohort included 452 adolescents, aged 11-14 years, recruited...
Leucine-rich α-2 glycoprotein1 (LRG1) is a member of the leucine-rich repeat (LRR) family that was implicated in multiple diseases including cancer, aging and heart failure as well diabetes obesity. LRG1 plays key role diet-induced hepatosteatosis insulin resistance by mediating crosstalk between adipocytes hepatocytes. also promotes upregulating de novo lipogenesis liver suppressing fatty acid β oxidation. In this study, we investigated association with obesity markers...
Abstract Background ANGPTL8 is known to regulate lipid metabolism and inflammation. It interacts with ANGPTL3 ANGPTL4 LPL activity, IKKα/β modulate NF-κB activity. Further, a SNP leading R59W variant associates reduced LDL/HDL increased FBG in Hispanic Arab individuals, respectively. In this study, we investigate the impact of on inflammatory activity ANGPTL8. Methods was genotyped discovery cohort 867 individuals from Kuwait. Plasma levels markers were measured tested for associations...
The corticotropin-releasing hormone (CRH) and urocortins (UCNs) have been implicated in energy homeostasis the cellular stress response. However, expression of these neuropeptides children remains unclear. Therefore, we determined impact obesity on their 40 who were normal weight, overweight, had obesity. Peripheral blood mononuclear cells (PBMCs) plasma used to assess neuropeptides. THP1 treated with 25 mM glucose 200 µM palmitate, gene was measured by real-time polymerase chain reaction...
Aims: Melanocortin 4 receptor (MC4R) has a well-established role in controlling appetite and hence regulating food intake energy homeostasis. Setmelanotide is an MC4R agonist indicated for weight control obese adults children older than 6 years of age with mutations the proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin (LEPR) deficiency. This study aims to compare structural functional aspects physiological α-melanocyte-stimulating hormone (α-MSH)...