A5031357749- Microfluidic and Bio-sensing Technologies
- Electrowetting and Microfluidic Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Sensor and Energy Harvesting Materials
- 3D Printing in Biomedical Research
- Orbital Angular Momentum in Optics
- Micro and Nano Robotics
- Photonic and Optical Devices
- Advanced optical system design
- Optical Coherence Tomography Applications
- Reproductive Biology and Fertility
- Photoreceptor and optogenetics research
- Plant and Biological Electrophysiology Studies
- Advanced Optical Imaging Technologies
- Insect and Arachnid Ecology and Behavior
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Fluorescence Microscopy Techniques
- Innovative Energy Harvesting Technologies
- Advanced MEMS and NEMS Technologies
- Molecular Communication and Nanonetworks
- Laser Material Processing Techniques
- Energy Harvesting in Wireless Networks
- Laser Applications in Dentistry and Medicine
- Mechanical and Optical Resonators
RIKEN Center for Biosystems Dynamics Research
2019-2022
Osaka University
2017-2022
Ube Frontier University
2017-2021
Glass is a common material used in various microsystems including sensors, actuators, and microfluidic devices due to its extraordinary properties. However, lack of flexibility elasticity limits potential for further applications. To solve this issue, thinning the thick glass plate few microns solution. conventional methods plates are complex, risky, time-consuming, difficult implementation at laboratory level. This paper reports an efficient convenient fabrication method independent...
We demonstrated a self-driven chemical micropump powered by self-oscillating motions of synthetic polymer gel converting energy into displacements thin polydimethylsiloxane (PDMS) sheet to produce directional flow via micro check valves. The oscillations induced the oscillatory Belousov-Zhabotinsky (BZ) reaction generate large volume change. To effectively exploit this change, bars were used as drivers. They sandwiched fixed cover glass and push-bar communicate expanding (pushing) force...
Abstract Bio-actuators and sensors are increasingly employed in microscale devices for numerous applications. Unlike other artificial actuated by living cells or tissues, here we introduce a microvalve system the stimuli-responsive action plant, Mimosa pudica (sleepy plant). This realizes control of valve to open close dropping recovering responses branch upon external physical stimulations. The results showed that one matured single uncut produced average force 15.82 ± 0.7 mN. was...
A flexible manipulation platform combines microheaters and an area cooling system to position manipulate single particles cells.
Single cell analysis has gained attention as a means to investigate the heterogeneity of cells and amplify with desired characteristics. However, obtaining single from large number remains difficult because preparation single-cell samples relies on conventional techniques such pipetting that are labor intensive. In this study, we developed system combining 0.6-mm thin glass microfluidic device machine vision approach isolate Euglena gracilis cells, model microorganism mobility, in small/thin...
We report an on-chip single-cell multidirectional observation method by accurately control the ultra-thin glass chamber rotation angles over microscope. This technique enables to establish visual accesses target cell that captured inside of thin chamber. The has advantages highly transparent, compact, wall, less invasive and all-closed structures efficiently reduces risks contamination during observation. fabricated chambers diameters were different from 1.5 3.5 mm which formed on 200 μm slides.
We present an efficient fabrication technique for a glass microdome structure (GMDS) based on the microthermal expansion principle, by inflating microcavities confined between two thin slides. This allows controlling height, diameter, and shape of GMDS with uniformity under 5%. The has high potential application microlens lens array. inflated hollow, is stable at extreme environments such as in strong acid temperature conditions. More importantly, hollow can be filled liquid substances to...
In this work, the authors report an all‐surfaces’ image capturing method of a single oocyte that uses micro‐scale rotational flow. Here, used gently and indirectly rotated pronuclear zygotes (physical properties are similar to those oocytes) obtain images all its surfaces in 0.33 s. The necessary equipment realise consists only syringe pump microfluidic chip with 40 µm diameter orifice. Assessment viability quality oocytes or embryos during process intra cytoplasmic sperm injection) vitro...
Microfluidic devices are important platforms to culture and observe biological tissues. Compared with conventional setups, microfluidic have advantages in perfusion, including an enhanced delivery of nutrients gases However, explanted tissues can maintain their functions for only hours days devices, although observations desired weeks. The suprachiasmatic nucleus (SCN) is a brain region composed heterogeneous cells control the clock system through synchronizing individual this region....
This paper presents a self-contained micro-optical system that is magnification-controlled by adjusting the positions of microlens in device via pneumatic air pressure. Unlike conventional dynamic microlenses made from liquid or polydimethylsiloxane (PDMS) change their shapes external actuation, this combines fixed-curvature glass microlens, an inflatable PDMS layer, and pressure supply as actuator. showed several advantages, including stable inflation, firm structure, light weight; it...
We demonstrated a pressure driven energy harvesting device using water and that features glass filter with porous channels. employed powder sintering to fabricate the (2 cm diameter, 3 mm thickness) by packing of borosilicate particles into carbon mold then thermally fusing this at 700°C under pressure. In constant flow rate experiment, optimum average pore radius for power generation was 12 μm. Using filter, 3.8 mW (27 V, 0.14 mA, 0.021% efficiency) generated speed 50 mm/s. generator...
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We report a simple and efficient glass microlens fabrication technique by thermally inflating the microcavities on thin slide. Due to joint effect of high-temperature vacuum pressure, are gradually formed into hollow, transparent, biconvex microlens. Based this method, we fabricated wide range that diameters from 30 μm 1 mm thickness 100 slide at single arrays distributions. evaluated morphologies, optical imaging quality, magnification power.
This paper reports a light controllable single cell driven micro rotary vane pump for transport fluid in small space based on new type of bio-actuator: Euglena. Different from other types bio-actuators, Euglena has features both animals and plants, which will allow, the first time, bio-actuator functioned fresh salt water take nourishment through photosynthesis. To demonstrate potential actuator, we fabricated simple chamber as structure, let swim chamber. Then, by irradiating with range 400...
In this paper, we report an imaging method of a single oocyte by using micro-scale rotational flow. This gently and indirectly rotates the target to obtain surface images in 0.176 s. The necessary equipment for is only syringe pump microfluidic chip with 40 μm diameter orifice.