A5066770364- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Renal and related cancers
- Mitochondrial Function and Pathology
- Electrospun Nanofibers in Biomedical Applications
- Assisted Reproductive Technology and Twin Pregnancy
- Diet and metabolism studies
- Bone Tissue Engineering Materials
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Microfluidic and Bio-sensing Technologies
- Adipose Tissue and Metabolism
- Microfluidic and Capillary Electrophoresis Applications
- Cellular Mechanics and Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism and Genetic Disorders
- Blood donation and transfusion practices
- Restless Legs Syndrome Research
- Polymer Surface Interaction Studies
- Polyamine Metabolism and Applications
- Bacteriophages and microbial interactions
- Mycotoxins in Agriculture and Food
- Vascular Malformations and Hemangiomas
- Enzyme-mediated dye degradation
Institute of Crystallography
2023
Institute for Microelectronics and Microsystems
2018-2019
Istituto Nazionale di Fisica Nucleare, Sezione di Lecce
2019
Istituto Nanoscienze
2010-2016
Italian Institute of Technology
2013-2016
Center for Biomolecular Nanotechnologies
2013-2016
University of Bari Aldo Moro
2006-2010
University of Salento
2010
We present a bio-inspired renal microdevice that resembles the in vivo structure of kidney proximal tubule. For first time, population tubular adult stem/progenitor cells (ARPCs) was embedded into microsystem to create bioengineered These have both multipotent differentiation abilities and an extraordinary capacity for injured cell regeneration. Therefore, ARPCs may be considered promising tool promoting regenerative processes treat acute chronic injury. Here were grown confluence exposed...
The major cause of synthetic vessel failure is thrombus and neointima formation. To prevent these problems the creation a continuous elongated endothelium inside lumen vascular grafts might be promising solution for tissue engineering. Different micro‐ nano‐surface topographic cues including grooved micro‐patterns electrospun fibers have been previously demonstrated to guide uniform alignment endothelial cells (ECs). Here, with very simple highly versatile approach we combined...
The objective of this study is elucidating the mechanisms by which wettability nanofibrous electrospun mats varies in polymer blends, and highlighting how can play a pivotal role enhancing viability cultured microvascular endothelial cells (EC). A functional network essential for supplying bioengineered tissues with oxygen nutrients while removing metabolic wastes. An vitro pre-vascularization strategy consists seeding EC on scaffolds, turn promotes infiltration, adhesion functionality. We...
The aim of this study was to evaluate the impact pre- mature progesterone rise on day human chorionic gonadotropin (hCG) administration outcome in vitro fertilization (IVF) frozen embryo transfer (FET) cycles using cleavage-stage embryos.This a retrospective, cohort 131 ovarian stimulation followed by transfers. first group consisted women undergoing FET due premature luteinization during controlled (n = 56, P ≥1.2 ng/ml). controls were represented not complicated high levels at induction...
Producing polymeric or hybrid microfluidic devices operating at high temperatures with reduced no water evaporation is a challenge for many on-chip applications including polymerase chain reaction (PCR). We study sample in and devices, realized by glass microchannels avoiding diffusion toward the elastomer used chip fabrication. The method dramatically reduces PCR that are found to exhibit optimal stability effective operation under oscillating-flow. This approach maintains flexibility, ease...
The effect of age and caloric-restriction (CR) diet on mitochondrial DNA (mtDNA) content in different rat tissues was investigated. A decrease the mtDNA occurs with aging liver soleus muscle, whereas there is no age-related significant change brain. CR fully reverses age-dependent loss soleus, it results a increase amount above value aged ad libitum fed rats These further support tissue-specific CR, likely because dependence external nutrient uptake.
Bioactive, electrospun polymer nanofibers (NFs) are attractive building‐block materials for realizing scaffolds tissue engineering, as these filaments structurally mimic the hierarchical organization of natural extracellular matrix. As presented in this article, demonstrated applications involve commitment to adipogenic, chondrogenic, osteogenic, neural lineages, and so on, by different types stem cells obtained from various sources (adult, embryonic, induced pluripotent cells, etc.). Since...
Abstract The effect of acetyl‐ L ‐carnitine (ALCAR) supplementation to 3‐month‐old rats in normal‐loading and unloading conditions has been here investigated by a combined morphological, biochemical transcriptional approach test whether ALCAR might cause remodeling the metabolic/contractile phenotype soleus muscle. Morphological assessment demonstrated an increase type I oxidative fiber content cross‐sectional area ALCAR‐treated animals both conditions. prevented loss mitochondrial mass...
The use of adult stem/progenitor cells is a challenge in current research about kidney functional regeneration. In this framework, material‐induced stem cell differentiation can become new paradigm to promote advances therapies. Here, the effects both isotropic and anisotropic fibrous topographies on podocyte renal (RSCs) from human donors are investigated. proliferation rate RSCs analyzed, immunofluorescence genetic analyses specific markers (Wilms’ tumor 1 gene, nephrin, podocin) performed...
In vivo cell niches are complex architectures that provide a wide range of biochemical and mechanical stimuli to control behavior fate. With the aim in vitro microenvironments mimicking physiological niches, microstructured substrates have been exploited support adhesion shape as well three dimensional morphology. At variance with previous methods, we propose simple rapid protein subtractive soft lithographic method obtain polydimethylsiloxane for studying stem growth. The adult renal cells...