T. Nishimura

ORCID: 0000-0002-4861-4293
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About
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Research Areas
  • Polyoxometalates: Synthesis and Applications
  • Alzheimer's disease research and treatments
  • Mitochondrial Function and Pathology
  • Extracellular vesicles in disease
  • Urological Disorders and Treatments
  • Chemical Synthesis and Characterization
  • Pediatric Urology and Nephrology Studies
  • Selenium in Biological Systems
  • Neurological diseases and metabolism
  • Birth, Development, and Health
  • Neurobiology of Language and Bilingualism
  • Renal Diseases and Glomerulopathies
  • Reproductive System and Pregnancy
  • Renal Transplantation Outcomes and Treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Platelet Disorders and Treatments
  • Metal-Organic Frameworks: Synthesis and Applications
  • Carcinogens and Genotoxicity Assessment
  • Advanced Thermoelectric Materials and Devices
  • Dementia and Cognitive Impairment Research
  • Analytical Methods in Pharmaceuticals
  • Catalytic Processes in Materials Science
  • Recycled Aggregate Concrete Performance
  • Glutathione Transferases and Polymorphisms
  • Rock Mechanics and Modeling

University of Tokyo Hospital
2023-2024

The University of Tokyo
1991-2023

Chiba Hospital
2022

Children's Medical Center
2022

Kanazawa Hospital
2012-2021

Osaka University
1983-2019

Asahi General Hospital
2019

National Institute of Advanced Industrial Science and Technology
2014

Ono Pharmaceutical (United Kingdom)
2004

Chukyo Hospital
2003

Mice lacking the gene encoding receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in estrous cycle, ovulation, fertilization, or implantation, they did not respond exogenous oxytocin because of lack induction (a proposed triggering event parturition), and show decline serum progesterone concentrations that precedes parturition. Ovariectomy day 19 pregnancy restored permitted...

10.1126/science.277.5326.681 article EN Science 1997-08-01

Background: The recurrence of lumbar disk herniation (LDH) is a major problem in the treatment LDH. purpose this study was to investigate risk factors for recurrent Methods: Between April 2005 and March 2008, 298 patients with LDH, who underwent surgical treatment, were enrolled study. divided into nonrecurrent group (N group) (R group). We compared their clinical parameters including age, sex, body mass index, smoking, alcohol, sports activity, occupational lifting, driving. relationships...

10.1097/bsd.0b013e31828215b3 article EN Journal of Spinal Disorders & Techniques 2012-12-18

The Lifshitz transition, a change in Fermi surface topology, is likely to greatly influence exotic correlated phenomena solids, such as high-temperature superconductivity and complex magnetism. However, since the observation of surfaces generally difficult strongly systems, direct link between transition quantum has been elusive so far. Here, we report marked impact pressure-induced on thermoelectric performance for SnSe, promising material without strong electron correlation. By applying...

10.1103/physrevlett.122.226601 article EN publisher-specific-oa Physical Review Letters 2019-06-07

Crj:CD(SD)IGS rats were orally administered valproic acid at doses of 250, 500 or 1000 mg / kg day for 4, 7 10 weeks. At each dose, one group male was euthanized after 4-week dosage (4-week dose group) and the other two mated with untreated females 4 (7-week (10-week weeks treatment their fertility evaluated. Females on 14-l7 gestation, numbers corpora lutea, implantations live dead fetuses recorded. After treatment, males euthanized, genital organs weighed, number sperm in cauda epididymis...

10.2131/jts.25.85 article EN The Journal of Toxicological Sciences 2000-01-01

Congenital disorders characterized by the quantitative and qualitative reduction in number of functional nephrons are primary cause chronic kidney disease (CKD) children. We aimed to describe alteration urinary extracellular vesicles (uEVs) associated with decreased renal function during childhood. By nanoparticle tracking analysis proteomics, we identified differentially expressed proteins uEVs bilateral hypoplasia, which is a congenitally reduced nephrons. This expression signature...

10.1016/j.isci.2022.105416 article EN iScience 2022-11-01

We have undertaken a systematic study of thermal conductivity as function temperature and magnetic field single crystals the compound (La$_{1-z}$Pr$_{z}$)$_{1.2}$Sr$_{1.8}$Mn$_{2}$O$_{7}$ for $z$(Pr) =0.2,0.4. 0.6. The lattice distortion due to Pr-substitution anisotropic in bilayer manganites are discussed on basis different relaxation models local distortions metal insulating states proposed by Maderda et al. giant magnetothermal effect is scaled magnetization variation occupation...

10.1103/physrevb.67.104433 article EN Physical review. B, Condensed matter 2003-03-31

The clinical outcomes of balloon kyphoplasty (BKP) for split-type osteoporotic vertebral fractures (OVF) are poor. These may be owing to the body bifurcating anteriorly and posteriorly when a load is applied filled cement being unstable. We report usefulness BKP combined with pediculoplasty using cannulated screws (vertebra-pediculoplasty) OVF risk dislodgement.Between April 2020 February 2021, this surgery was performed on 10 patients delayed-union OVF. diagnosis made imaging findings...

10.1016/j.wneu.2021.07.142 article EN cc-by World Neurosurgery 2021-08-06

This paper investigated the effect of combining rubber crumbs with recycled aggregates and fly ash on mechanical properties environmental impact concrete. Increasing amount linearly reduced strength Young's modulus regardless aggregate or binder type, but decreased as increased. Air permeability also increased varied, it was constant in case non-fly completely ash. The mechanical–environmental efficiency calculated by weighting volume raw materials, were found to have highest whereas...

10.1080/19397038.2011.569584 article EN International Journal of Sustainable Engineering 2011-04-10

We describe a new technique of endoscopic antireflux surgery. The principle the procedure is to make reliable muscular backing and elongate intramural ureter.We performed this surgery in 8 female patients whom 4, 1, 1 refluxing ureters (total 14) were diagnosed with grades I IV reflux, respectively. operation consists 3 steps. Two 5 mm. locking trocars are placed into bladder. Irrigation done 3% D-sorbitol solution bladder wall incised upward along each side ureter using resectoscope 2 cm....

10.1097/01.ju.0000047362.12606.49 article EN The Journal of Urology 2003-03-01

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10.14359/5650 article EN 1999-01-01

The molecular profile of extracellular vesicles released in urine reflects the pathophysiological processes occurring within originating cells located diverse nephron segments. Here, we present an enzyme-linked immunosorbent assay for quantitative membrane protein detection human samples. We describe steps preparing samples, biotinylated antibodies, and microtiter plates to purify detect membrane-bound biomarkers. specificity signals limited variability by freeze-thaw cycles or...

10.1016/j.xpro.2023.102415 article EN cc-by-nc-nd STAR Protocols 2023-07-10

A collaborative study was conducted to determine useful and sensitive rat sperm motion parameters in a CellSoft Series 4000 semen analyzer detect the effects of compounds on motion. The were investigated using alpha-chlorohydrin, boric acid, ethinylestradiol, ethyl methanesulfonate, nitrazepam, nitrobenzene, ornidazole, sulfasalazine or valproic acid which are well known induce reproductive testicular toxicities. All used this decreased percentage motile (% motile). Curvilinear velocity...

10.2131/jts.26.9 article EN The Journal of Toxicological Sciences 2001-01-01

To determine an appropriate administration period and sensitive end-points for the evaluation of effects on male fertility, Sprague-Dawley rats were orally given nitrofurazone, a model compound, at doses 12.5, 25, or 50 mg/kg/day 4 weeks, 12.5 25 9 weeks before mating with untreated females. Copulation fertility indices decreased, pregnancy did not result over both dosing periods. An increase in preimplantation loss, decreases implants live fetuses observed after 9-weeks dosing. However, no...

10.2131/jts.20.341 article EN The Journal of Toxicological Sciences 1995-01-01

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTOxidative Coupling of Methane in the Gas Phase: Simulation and Reaction MechanismY. Sekine, T. Nishimura, K. FujimotoView Author Information Department Applied Chemistry, Faculty Engineering, The University Tokyo, Hongo, Japan 113-8656 Cite this: Energy Fuels 1998, 12, 4, 828–829Publication Date (Web):June 24, 1998Publication History Received13 January 1998Published online24 June inissue 1 July...

10.1021/ef9800011 article EN Energy & Fuels 1998-06-24

SUMMARY 1. The study was done to determine whether long‐term treatment with lithium carbonate affected the guanosine triphosphate (GTP)‐binding protein in platelet membranes from patients manic depression. 2. It found that adenosine diphosphate (ADP)‐ribosylation of inhibitory G‐proteins (40–41 kDa) by pertussis toxin, islet‐activating cell increased about 45% when stopped. 3. These results support idea one site for therapeutic effects ions is G‐proteins.

10.1111/j.1440-1681.1990.tb01283.x article EN Clinical and Experimental Pharmacology and Physiology 1990-11-01
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