A5075975664- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Bacterial Identification and Susceptibility Testing
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Salmonella and Campylobacter epidemiology
- Research in Social Sciences
- Plant Virus Research Studies
- Vector-borne infectious diseases
- Health disparities and outcomes
- Research on Leishmaniasis Studies
- Escherichia coli research studies
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Animal health and immunology
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- vaccines and immunoinformatics approaches
- Urinary Tract Infections Management
- Bacterial biofilms and quorum sensing
Kenya Medical Research Institute
2024-2025
Walter Reed Army Institute of Research
2024-2025
United States Army Medical Research Directorate - Africa
2023-2024
International Centre of Insect Physiology and Ecology
2022-2023
Jomo Kenyatta University of Agriculture and Technology
2020
This study describes the identification of
ABSTRACT We report the genome sequences of 14 Acinetobacter phages isolated in Kenya, belonging to genera Friunavirus and Obolenskvirus . They have double-stranded DNA with sizes between 39 45 kb G + C content from 38% 39%. The genomes contain 56 93 predicted coding sequences.
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Enterococcus faecalis is a growing cause of nosocomial and antibiotic-resistant infections. Treating drug-resistant E. requires novel approaches. The use bacteriophages (phages) against multidrug-resistant (MDR) bacteria has recently garnered global attention. Biofilms play vital role in pathogenesis as they enhance antibiotic resistance. Phages eliminate biofilms by producing lytic enzymes, including depolymerases. In this study, phage vB_Efs8_KEN04 (ФKEN04), isolated from sewage treatment...
We report the genome sequences of four
Surveillance of antimicrobial resistance in Kenya, Uganda, and Jordan identified multidrug-resistant high-risk bacterial clones: Escherichia coli sequence types 131, 1193, 69, 167, 10, 648, 410, 405 Klebsiella pneumoniae 14, 147, 307, 258. Clones emerging those countries exhibited high mechanism diversity, highlighting a serious threat for multidrug resistance.
Genomic surveillance is vital for detecting outbreaks and understanding the epidemiology transmission of bacterial strains, yet it not integrated into many national antimicrobial resistance (AMR) programmes. Key factors are that few scientists in public health sector trained genomics, diverse sequencing platforms bioinformatic tools make challenging to generate reproducible outputs. In Kenya, these gaps were addressed by training conduct genomic on isolates from AMR repository produce...
We determined antibiotic susceptibility and employed Oxford Nanopore whole-genome sequencing to explore strain diversity, resistance, virulence gene carriage among methicillin-resistant Staphylococcus aureus (MRSA) strains from different infection sites timepoints in a tertiary Kenyan hospital. Ninety-six nonduplicate clinical isolates recovered between 2010 2023, identified tested for on the VITEK ID/AST platform, were sequenced. Molecular typing, determinant screening performed using...
Escherichia coli and Shigella spp. are leading bacterial causes of acute diarrhea in sub-Saharan Africa pose risks to global communities, travelers, the US military. Increasing antimicrobial resistance (AMR) those other enteric pathogens creates treatment challenges for clinicians. Inappropriate use drugs, such as azithromycin viral respiratory infections, increased during COVID-19 pandemic. We evaluated AMR trends 116 E. 109 isolates obtained from 1,672 pre-COVID-19 (2017-2019) 1,118...
Background: Livestock are key sources of livelihood among pastoral communities. productivity is chiefly constrained by pests and diseases. Due to inadequate disease surveillance in northern Kenya, little known about pathogens circulating within livestock the role livestock-associated biting keds (genus Hippobosca) transmission. We aimed identify prevalence selected hemopathogens their associated blood-feeding keds. Methods: randomly collected 389 blood samples from goats (245), sheep (108),...
ABSTRACT We report the genome sequences of 12 Enterococcus faecalis phages isolated in Kenya, belonging to genus Copernicusvirus , Efquatrovirus Saphexavirus and Kochikohdavirus . They have double-stranded DNA with lengths varying from 17,979 147,374 bp G+C content 33.14% 40.05%. The genomes contain 28–250 coding sequences.
<ns3:p>Background Pseudomonads are gram negative bacteria and readily form biofilms in the environment, allowing long-term colonization persistence sinks, water systems. They pose a risk of life-threatening opportunistic infections immune-compromised individuals. MDR strains, make treatment increasingly difficult. Environmentally persistent strains typically problematic within healthcare facilities, however, data on pseudomonad reservoirs settings with community-acquired to inform preventive...
ABSTRACT The genomes of three Pseudomonas aeruginosa Phikzvirus bacteriophages isolated in Kenya are described. phages vB_PaePAO1-KEN19, vB_Pae3705-KEN49, and vB_Pae10145-KEN51, respectively, had lengths 278,921, 280,231, 280,173 bp, with 36.93%, 36.84%, 36.86% GC content, containing 419, 417, 417 coding sequences (including seven tRNAs each genome).
Abstract The recent outbreak of severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) causing disease (covid19) has posed a great threat to human health. Previous outbreaks SARS-CoV and Middle East Syndrome CoV (MERS-CoV) from the same family had similar health economic growth. To date, not even single drug specific any these CoVs been developed nor anti-viral vaccine is available for treatment diseases caused by CoVs. Subunits present in spike glycoproteins SARS-CoV-2...
Visceral and cutaneous leishmaniasis are endemic to specific regions due the ecological preferences of phlebotomine sand flies Leishmania spp. transmission. Sand fly entomological data in northern Kenya scarce limited studies neglect leishmaniasis. The aim this study was investigate: (i) diversity distribution; (ii) occurrence DNA within flies; (iii) blood-meal sources Laisamis, Kenya. We conducted an survey during February March 2021 five areas Laisamis sub-county using standard CDC light...