A5036463813- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Diet, Metabolism, and Disease
- Cancer Mechanisms and Therapy
- Growth Hormone and Insulin-like Growth Factors
- Cytokine Signaling Pathways and Interactions
- Cardiac Health and Mental Health
- Phytochemical compounds biological activities
- Endometriosis Research and Treatment
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Signaling Pathways in Disease
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Health, psychology, and well-being
- Ubiquitin and proteasome pathways
- Neuroblastoma Research and Treatments
- Folate and B Vitamins Research
- Galectins and Cancer Biology
Shandong University of Traditional Chinese Medicine
2022-2025
National University Cancer Institute, Singapore
2024
Qilu Hospital of Shandong University
2023
Weatherford College
2022
Necroptosis, a programmed form of necrotic cell death, plays critical regulatory roles in the progression and metastatic spread cancers such as cervical squamous carcinoma endocervical adenocarcinoma (CESC). However, there are few articles systematically analyzing necroptosis-related long non-coding RNAs (NRlncRNAs) correlated with CESC patients. Both RNA-sequencing clinical data patients downloaded from TCGA database this study. Pearson correlation analysis, least absolute shrinkage,...
Background: Using bioinformatics analysis and experimental operations, we intend to analyze the potential mechanism of action capsaicin target gene GATA1 in treatment uterine corpus endometrial carcinoma (UCEC) develop a prognostic model for disease validate this model. Methods: By obtaining UCEC-related DR-DEGs, prognosis-related was screened. The survival conducted via establishing high low expression groups GATA1. Whether could be an independent factor UCEC, it also validated. therapeutic...
Necroptosis is one of the common modes apoptosis, and it has an intrinsic association with cancer prognosis. However, role necroptosis-related long non-coding RNA LncRNA (NRLncRNAs) in uterine corpora endometrial (UCEC) not yet been fully elucidated at present. Therefore, present study designed to investigate potential prognostic value LncRNAs UCEC. In study, expression profiles clinical data UCEC patients were downloaded from TCGA database identify differentially expressed NRLncRNAs...
Endometrial carcinoma is one of the two cancers with rising mortality and morbidity in recent years. In light many controversies about its treatment, it urgent to construct a new prognostic model find out therapeutic directions. As small drug molecule widely used clinical treatment experimental research China, puerarin has recently been proven have obvious anti-cancer effects multiple cancer cells. this study, bioinformatics analysis validation were explore potential mechanism for...
Recent studies have suggested a potential correlation between ecological dysregulation of the gut microbiota (GM) and onset development postpartum depression (PPD). In addition, inflammatory factors (IFs) been reported to play an important role in PPD. However, causal connections among GM, IFs, PPD remain be understood. This study sought determine if genetically predicted GM IFs exert effect on whether mediate Two-step two-sample Mendelian randomization (MR) analyses, primarily employing...
Previous researches have demonstrated a connection between psychiatric disorders and cardiovascular diseases (CVDs), but the cause-and-effect relationship is still unclear. To that goal, mendelian randomization (MR) method was used to study causal link CVDs.Genome-wide association studies (GWAS) data were collected for four CVDs, including coronary artery disease (n = 547,261), atrial fibrillation 537,409), heart failure 977,323) ischemic stroke 440,328). Summary disorders, bipolar disorder...
N 6 -methyladenosine (m A) RNA methylation is a prevalent modification that significantly impacts metabolism and cancer development. Maintaining the global m A levels in cells relies on accessibility to methyltransferases availability of methyl donor S-adenosylmethionine (SAM). Here, we reveal death associated protein 3 (DAP3) plays crucial role preserving through two distinct mechanisms. First, although DAP3 not component writer complex, it directly binds target regions, thereby...
Abstract Previous observational researches have discovered a connection between circulating concentrations of micronutrients and attention deficit hyperactivity disorder (ADHD). However, the results may be influenced by confounding factors reverse causation. This study aims to explore causal relationship ADHD using Mendelian randomization (MR). In two-sample MR context, we used summary data from major European genome-wide association studies (GWAS) for these illnesses assess genetically...
Background: In recent years, the role of metformin in girls with precocious puberty (PP) has been increasingly frequently studied. The objective this present study is to assess effect on low birth weight (LBW-PP girls). Methods: We search confirmed studies about circulating and PP from databases EMBASE, PubMed, Web Science. Data were reported as weighted mean difference (WMD) associated 95% confidence intervals (CIs). Analysis was performed by Review Manager 5.3 Stata version 12.0. Results:...
Abstract Background Neuroblastoma, a prevalent solid tumor in children, often manifests with hidden onset sites, rapid growth, and high metastatic potential. The prognosis for children high-risk neuroblastoma remains poor, highlighting the urgent need novel prognostic models therapeutic avenues. In recent years, puerarin, as kind of small molecule drug extracted from Chinese medicine Pueraria lobata, has demonstrated significant anticancer effects on various cancer cell types. this study,...
Abstract Context: Obesity is the world's most high-profile public health problem. Kudingcha has been used in traditional medicine because of its antioxidant, anti-inflammatory and weight loss properties. Quercetin kaempferol are main components rich that effective against obesity. Objective We method network pharmacology to study effects quercetin HepG2 cells on Materials & methods obtained 20 hub genes through PPI results Cytoscape plug-in cytoHubba. The top 10 were found eventrully by...
Abstract Obesity is the world's most high-profile public health problem. Kudingcha has been used in traditional medicine because of its antioxidant, anti-inflammatory and weight loss properties. Quercetin kaempferol are main components rich that effective against obesity. Therefore, we method network pharmacology to study effects quercetin HepG2 cells on We obtained 20 hub genes through PPI results Cytoscape plug-in cytoHubba. The top 10 were found eventrully by GO KEGG enrichment analysis....