A5079154635- Tryptophan and brain disorders
- Vitamin D Research Studies
- Stress Responses and Cortisol
- Exercise and Physiological Responses
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Biomarkers in Disease Mechanisms
- Bird parasitology and diseases
- Adrenal Hormones and Disorders
- Insect and Pesticide Research
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sex and Gender in Healthcare
- Reproductive System and Pregnancy
- Circadian rhythm and melatonin
- Biochemical and Molecular Research
- Lipid metabolism and disorders
- Immune cells in cancer
- Nail Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
Augusta University
2017-2020
Augusta University Health
2020
Extracellular vesicles (EVs) are known to play important roles in cell-cell communication.Here we investigated the role of muscle-derived EVs and their microRNAs loss bone stem cell populations with age.Aging male female C57BL6 mice was associated a significant increase expression senescenceassociated microRNA miR-34a-5p (miR-34a) skeletal muscle serum -derived EVs.Muscle-derived, alpha-sarcoglycan positive, isolated from samples also showed miR-34a age.EVs were conditioned medium C2C12...
The PKR-like ER kinase (PERK), a transmembrane protein, resides in the endoplasmic reticulum (ER). Its activation serves as key sensor of stress, which has been implicated traumatic brain injury (TBI). loss memory is one most common symptoms after TBI, but precise role PERK impairment TBI not well elucidated. Here, we have shown that blocking using GSK2656157 prevents dendritic spines and rescues deficits TBI. To elucidate molecular mechanism, found activated phosphorylates CAMP response...
The cellular and molecular mechanisms underlying loss of muscle mass with age (sarcopenia) are not well-understood; however, heterochronic parabiosis experiments show that circulating factors likely to play a role. Kynurenine (KYN) is tryptophan metabolite known increase ligand the aryl hydrocarbon receptor (Ahr). Here, we tested hypothesis KYN activation Ahr plays role in aging. Results indicate treatment mouse human myoblasts increased levels reactive oxygen species (ROS) 2-fold vivo...
Traumatic brain injury (TBI) is a major source of worldwide morbidity and mortality. Patients suffering from TBI exhibit higher susceptibility to bone loss an increased rate fractures; however, the underlying mechanisms remain poorly defined. Herein, we observed significantly lower quality elevated levels inflammation in marrow niche after controlled cortical impact-induced vivo CD-1 mice. Further, identified dysregulated NF-κB signaling, established mediator osteoclast differentiation loss,...
Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis are still incompletely understood. We recently demonstrated that kynurenine (KYN), a tryptophan metabolite, accumulates serum of aged mice induces loss. Here, we report on novel mechanisms underlying KYN's detrimental effect aging. show KYN is increased with aging murine marrow mesenchymal stem cells (BMSCs). reduces via modulating levels CXCL12 its receptors as well histone deacetylase 3 (Hdac3)....
ABSTRACT Hallmarks of aging-associated osteoporosis include bone loss, marrow adipose tissue (BMAT) expansion, and impaired osteoblast function. Endogenous glucocorticoid levels increase with age, elevated signaling, associated chronic stress dysregulated metabolism, can have a deleterious effect on mass. Canonical signaling through the receptor (GR) was recently investigated as mediator during caloric restriction. To address role GR in an osteoporotic phenotype, current study utilized...
Deficiency in carnitine-palmityl-transferase (CPT) was demonstrated a 20-year-old man with paroxysmal myoglobinuria, after failure to discover another cause. It is concluded that muscular CPT deficiency must be excluded before recurrent myoglobinuria classified as "idiopathic".
The cellular and molecular mechanisms underlying loss of muscle mass strength with age (sarcopenia) are not well‐understood. Kynurenine (KYN) is a circulating tryptophan metabolite that generated by the enzyme Indoleamine, 2, 3 dioxygenase (IDO), known to increase age, implicated in several age‐related pathologies. We have previously shown an KYN young mice increased oxidative stress decreased skeletal mass, whereas inhibition using small‐molecule inhibitor IDO 1‐methyl‐D‐tryptophan (1MT)...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Traumatic brain injury (TBI) is a major source of worldwide morbidity and mortality. Patients suffering from TBI exhibit higher susceptibility to bone loss an increased rate fractures; however, the underlying mechanisms remain poorly defined. Herein, we observed significantly lower quality elevated levels inflammation in marrow niche after controlled cortical impact-induced in-vivo CD-1 mice. Further, identified dysregulated NFB signaling, established mediator osteoclast differentiation...
Loss of muscle mass and power with age in the form sarcopenia is associated a loss independence substantial decrease quality life due to an increase falls fractures. The cellular molecular mechanisms underlying are not well‐understood; however, heterochronic parabiosis experiments have revealed that circulating factors likely play role, reactive oxygen species (ROS) also known skeletal aging. This study investigated relationship between kynurenine, tryptophan metabolite which increases age,...
Muscle atrophy and bone loss are known to occur in settings of disuse such as prolonged bedrest, spinal cord injury, or exposure microgravity with spaceflight. It is also well‐established that crosstalk exists between muscle mediated by myokines myostatin irisin, changes these muscle‐derived factors exercise, aging, may contribute formation resorption. many cases often precedes loss, can be more rapid relative detectable mass density. We investigated short‐term (2 weeks) utilizing a single...