A5000198303- Bone health and treatments
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Vitamin D Research Studies
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- TGF-β signaling in diseases
- Biomarkers in Disease Mechanisms
- dental development and anomalies
- Bone and Dental Protein Studies
- Bone health and osteoporosis research
- Oral and Maxillofacial Pathology
- Facial Trauma and Fracture Management
- Glycosylation and Glycoproteins Research
- Endodontics and Root Canal Treatments
- Effects of Vibration on Health
- Hematopoietic Stem Cell Transplantation
- Dental Erosion and Treatment
Western University of Health Sciences
2021-2024
Augusta University
2011-2020
Augusta University Health
2011-2018
Georgia Regents Medical Center
2013-2016
Government of the Republic of Korea
2016
RELX Group (United States)
2016
Detroit R&D (United States)
2016
Pomona College
2016
Texas A&M University System
2007
Baylor University
2007
Reconstruction of cranial and maxillofacial defects is a challenging task. The standard reconstruction method has been bone grafting. In this review, we shall describe the biological principles graft healing, as pertinent to craniofacial reconstruction. Different types sources grafts will be discussed, well new methods defect
Age-dependent bone loss occurs in humans and several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age-associated increase the generation of reactive oxygen species has been frequently implicated. We previously reported that aromatic amino acids function as antioxidants, anabolic for bone, they may potentially play a protective role aging environment. hypothesized upon oxidation would not only lose their effects but also become...
Increasing evidence suggests that stromal cell-derived factor-1 (SDF-1/CXCL12) is involved in bone formation, though underlying molecular mechanisms remain to be fully elucidated. Also, contributions of SDF-1β, the second most abundant splice variant, as an osteogenic mediator obscure. We have shown SDF-1β enhances osteogenesis by regulating morphogenetic protein-2 (BMP-2) signaling vitro. Here we investigate dose-dependent contribution suboptimal BMP-2-induced local formation; is, a dose...
Loss of muscle and bone mass with age are significant contributors to falls fractures among the elderly. Myostatin deficiency is associated increased in mice, dogs, cows, sheep humans, mice lacking myostatin have been observed show density limb, spine, jaw. Transgenic overexpression propeptide, which binds inhibits active ligand, also increases mice. We therefore sought test hypothesis that vivo inhibition using an injectable propeptide (GDF8 propeptide-Fc) would increase both aged (24 mo)...
In mammals, interactions between the bone marrow (BM) stroma and hematopoietic progenitors contribute to bone-BM homeostasis. Perinatal growth ossification provide a microenvironment for transition definitive hematopoiesis; however, mechanisms orchestrating development of skeletal systems remain largely unknown. Here, we establish intracellular O-linked β-N-acetylglucosamine (O-GlcNAc) modification as posttranslational switch that dictates differentiation fate niche function early BM stromal...
This study aims to develop a reproducible rat model for post-traumatic bisphosphonate-related osteonecrosis of the jaw (BRONJ). In our previous studies using dental extraction as an inducing factor, only 30%-60% zoledronate-treated animals fulfilled definition clinical BRONJ. We modified zoledronate regimen and introduced repeated surgical illicit quantifiable BRONJ in all animals. Eighty retired-breeder female Sprague-Dawley rats were divided between treatment (i.v. zoledronate; 80...
Whole-body vibration (WBV) has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of are scarce. To determine whether WBV recapitulates and osteogenic physical activity, we exposed male wild-type (WT) leptin receptor-deficient (db/db) mice to daily treadmill (TE) or for 3 months. Body weights were analyzed compared WT db/db that remained sedentary. Glucose insulin tolerance testing revealed comparable attenuation hyperglycemia resistance in...
Dendritic cells are an important link between innate and adaptive immune response. The role of dendritic in bone homeostasis, however, is not understood. Osteoporosis medications that inhibit osteoclasts have been associated with osteonecrosis, a condition limited to the jawbone, thus called medication-related osteonecrosis jaw. We propose disruption local response renders oral microenvironment conducive osteonecrosis. tested whether zoledronate (Zol) treatment impaired cell (DC) functions...
ABSTRACT Craniosynostosis (CS) is a relatively common birth defect resulting from the premature fusion of one or more cranial sutures. Human genetic studies have identified several genes in association with CS. One such gene that has been implicated both syndromic (Saethre–Chotzen syndrome) and nonsyndromic forms CS humans TWIST1 . In this study, heterozygous Twist1 knock out ( +/− ) mouse model was used to study craniofacial shape changes associated partial loss function. A geometric...
Purpose: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. Methods: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic (GK group), (3) GK fed (100 mg/kg body weight per day) in their water for 4 weeks + Met group). The right maxillary first molars extracted sites allowed 1 month heal. Titanium implants (1 × mm) placed healed extraction sites....
Abstract Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair complete regeneration. External factors can alter this process, leading to delayed or failed healing. The findings of recent studies suggest that the use selective serotonin reuptake inhibitors (SSRIs) reduce mass, precipitate osteoporotic fractures increase rate dental implant failure. With 10% Americans prescribed antidepressants, potential SSRIs impair may adversely...
Traumatic brain injury (TBI) is a major source of worldwide morbidity and mortality. Patients suffering from TBI exhibit higher susceptibility to bone loss an increased rate fractures; however, the underlying mechanisms remain poorly defined. Herein, we observed significantly lower quality elevated levels inflammation in marrow niche after controlled cortical impact-induced vivo CD-1 mice. Further, identified dysregulated NF-κB signaling, established mediator osteoclast differentiation loss,...
The ability of recombinant human bone morphogenetic protein 2 on absorbable collagen sponge (rhBMP2/ACS) to regenerate in segmental defect has been well characterized. However, clinical results rhBMP2/ACS constructs secondary reconstruction large mandibular and craniofacial defects have not consistent. We hypothesized that rhBMP2 delivery triggers an endogenous response the soft tissues surrounding defect, form expression BMP2 vascular endothelial growth factor (VEGF). Such osteogenic will...