A5102755937- Microbial Metabolic Engineering and Bioproduction
- Anesthesia and Neurotoxicity Research
- Biofuel production and bioconversion
- Anesthesia and Sedative Agents
- Drug-Induced Hepatotoxicity and Protection
- S100 Proteins and Annexins
- Phytoestrogen effects and research
- Pulmonary Hypertension Research and Treatments
- Tryptophan and brain disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease and Transplantation
- Antimicrobial agents and applications
- Phytochemicals and Antioxidant Activities
- Plant Pathogens and Fungal Diseases
- Nanoparticle-Based Drug Delivery
- Mycotoxins in Agriculture and Food
- Glaucoma and retinal disorders
- Chromium effects and bioremediation
- Connexins and lens biology
- Hearing, Cochlea, Tinnitus, Genetics
- Adipose Tissue and Metabolism
- Plant-Microbe Interactions and Immunity
- Sirtuins and Resveratrol in Medicine
- Advanced Nanomaterials in Catalysis
- Antimicrobial Peptides and Activities
Zhengzhou University
2024
Beijing University of Chinese Medicine
2020-2021
State Key Laboratory of Food Science and Technology
2021
Nanchang University
2021
Shandong University of Traditional Chinese Medicine
2021
Xuzhou University of Technology
2017-2020
Tianjin University
2020
Eye & ENT Hospital of Fudan University
2020
Hainan University
2018
Hyogo Medical University
2017
Acetaminophen (APAP) refers to a medication used manage pain and fever symptoms, but it always causes liver injury when overdosed. Zhishi, dried young fruit of Citrus aurantium L., is famous herbal medicine in Asian countries which rich dietary phenolic substances. In this study, the mechanism Zhishi protected against APAP-induced was studied more deeply by metabolomic strategy pharmacological study. The metabolomics results demonstrated that can prevent model regulating metabolic disorders...
Cardiac hypertrophy is an important characteristic in the development of hypertensive heart disease. Mitochondrial dysfunction plays role pathology cardiac hypertrophy. Recent studies have shown that sirtuin 3 (SIRT3)/poly (ADP-ribose) polymerase-1 (PARP-1) pathway modulation inhibits Quercetin, a natural flavonol agent, has been reported to attenuate However, molecular mechanism not completely elucidated. In this study, we aimed explore underlying protective effect quercetin on...
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective this study to investigate the effects vascular endothelial growth factor receptor 1 (VEGFR1) blockade on complications DR. Experimental models diabetes were induced with streptozotocin (STZ) treatment or Insulin2 gene mutation (Akita) mice. Protein expression and localization examined by western blots (WB) immunofluorescence (IF). mRNA was quantified PCR array real-time PCR. activity VEGFR1...
Novel bioactive components have greatly attracted attention as they demonstrate health benefits. Reversed-phase high performance liquid chromatography (RP-HPLC) showed that isoflavonoid compounds of kudzu root (Pueraria lobata) fermented by Eurtotium cristatum and extracted using de-ionized water were higher active compared with non-fermented. A model H2O2-inducd cell damage was built rat pheochromocytoma line 12 (PC12) to observe the protective effect non-fermented (NFK) (FK). Cell...
Abstract: Etiological evidence demonstrates that there is a significant association between cigarette smoking and chronic airway inflammatory disease. Abnormal expression of placental growth factor (PlGF) has been reported in COPD, its downstream signaling molecules have to contribute the pathogenesis epithelial cell apoptosis emphysema. However, mechanisms underlying smoke extract (CSE)-induced PlGF microenvironment remain unclear. Herein, we investigated effects reactive oxygen species...
In utero, exposure to sevoflurane (a commonly used inhalation anesthetic) can lead hearing impairment in offspring mice, but the underlying mechanism is not known.Day-15 pregnant mice were treated with 2.5% for 2 h investigate ototoxicity. Cochleae from harvested hair-cell and ribbon-synapse assessments. Hearing was assessed at postnatal day 30 using an auditory brainstem-response (ABR) test. Cochlear-explant cultures exposed 6 h. Immediately after treatment, explants morphology,...
Major depressive disorder (MDD) is a prevalent that causes considerable disability in social functioning and risk factor for physical diseases. Recent clinical reports have demonstrated marked association between MDD physiological dyshomeostasis induced by metabolic disorders, including diabetes, hormone abnormalities autoimmune The authors of the present study previously analyzed comparative gene expression profiles prefrontal cortex (PFC) chronic mild stress (CMS) animal model MDD....
Immobilized Rhizopus oryzae culturing may be a solution to the inhibited production of L(+)-lactic acid in submerged fermentation, which is caused by aggregated mycelia floc. In present study, R. mutant (RL6041) with 90% conversion rate glucose into L-lactic was obtained N+ implantation under optimized conditions beam energy 15 keV and dose 2.6 × 1015 ions/cm2. Using polyurethane foam as immobilization matrix, optimal were determined 4 mm foam, 150 r/min, 50 g/L ∼ 80 initial glucose, 38°C pH...
Abstract 3‐Hydroxypropionic acid (3HP) is an important platform chemical with a wide range of applications. The biological preparation this compound safe and low cost. In study, orchard soil human waste were used as raw materials to screen microbial strains that could produce 3HP in selective medium containing varying amounts propionic acid. A yeast strain can use substrate 48.96 g/L was screened. Morphological observation, physiological biochemical identification, 26s rDNA sequencing...
Erythritol is a novel 4-carbon sugar alcohol produced by microbes in the presence of hyper-osmotic stress. It has excellent potential to serve as an alternative for people with diabetes and also platform compound synthesizing various C4 compounds, such 1, 3-butadiene, 4-butanediol, 2, 5-dihydrofuran so on. Compared other polyols, fermentative production erythritol more challenging.
The aim of this study was to screen a strain for the removal Cd2+ from aqueous solution and investigate characterization mechanism binding process. A novel yeast showed high tolerance cadmium, namely Cystobasidium oligophagum QN-3, isolated soils, which could resist 22,000 mg/L 18,000 on PDA (potato dextrose agar) plate in liquid medium, respectively. experiment that remove effectively, maximum rate 84.45% achieved at initial concentration 30 mg/L. Scanning electron microscopy (SEM) analysis...
Objective To explore the role and molecular mechanism of forkhead transcription factor O1(FoxO1) on cellular mitochondrial injury in conditionally immortalized mouse podocyte cell line (CIMPs) under high glucose (HG) conditions. Methods The CIMPs cells were infected by constitutively active FoxO1 lentiviral vector (LV-CA-FoxO1) or empty (LV-NC), cultured different levels (5.5 mmol/L for normal 25.0 glucose). The divided into 4 groups: group NG (normal glucose), HG (high...