A5102949522- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Advanced Proteomics Techniques and Applications
- Lung Cancer Research Studies
- Mass Spectrometry Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Chronic Lymphocytic Leukemia Research
- Autophagy in Disease and Therapy
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Histone Deacetylase Inhibitors Research
- Advanced Biosensing Techniques and Applications
- Gastric Cancer Management and Outcomes
- Folate and B Vitamins Research
- Lung Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Immune Cell Function and Interaction
- Advanced Breast Cancer Therapies
- Retinal Diseases and Treatments
Guangxi Medical University
2012-2024
University of Alabama at Birmingham
2015-2024
Southwestern Institute of Physics
2024
Southwest University
2022-2023
Nanjing Drum Tower Hospital
2021-2023
Shanghai Jiao Tong University
2023
Ruijin Hospital
2023
Tumor Hospital of Guangxi Medical University
2014-2022
First Affiliated Hospital of Wenzhou Medical University
2019-2020
Wenzhou Medical University
2019-2020
Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition characterized by somatic mutations in the blood otherwise healthy adults. We hypothesized that patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at time ASCT would be associated with increased risk myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related neoplasm (TMN), other adverse outcomes. Methods performed whole-exome sequencing on...
A new diabetic mouse strain, the Akita.PlGF knockout (−/−), was generated to study role of placental growth factor (PlGF) in pathogenesis retinopathy (DR). PlGF deletion did not affect blood glucose but reduced body weight Akita.PlGF−/− mice. Diabetes-induced retinal cell death, capillary degeneration, pericyte loss, and blood-retinal barrier breakdown were prevented these Protein expression upregulated by diabetes, particularly vascular cells. degradation ZO-1 VE-cadherin reversed due...
Abstract Background QL1706 (PSB205) is a single bifunctional MabPair (a novel technical platform) product consisting of two engineered monoclonal antibodies (anti-PD-1 IgG4 and anti-CTLA-4 IgG1), with shorter elimination half-life (t 1/2 ) for CTLA-4. We report results from phase I/Ib study in patients advanced solid tumors who failed standard therapies. Methods In the I study, was administered intravenously once every 3 weeks at one five doses ranging 0.3 to 10 mg/kg, maximum tolerated...
Therapy-related myeloid neoplasm (t-MN) is a life-threatening complication of autologous peripheral blood stem cell transplantation (aPBSCT) for Hodgkin lymphoma (HL). Although previous studies have reported an association between clonal hematopoiesis (CH) in the infused PBSC product and subsequent post-aPBSCT risk t-MN patients with non-HL, information about HL treated aPBSCT not available.
// Vishnu C. Ramani 1, 2 , Fenghuang Zhan 3, 4 Jianbo He 1 Paola Barbieri 5 Alessandro Noseda Guido Tricot Ralph D. Sanderson Department of Pathology, University Alabama at Birmingham, AL, USA Comprehensive Cancer Center, 3 Internal Medicine, Iowa, Iowa City, IA, Holden Sigma-tau Research Switzerland S.A., Mendrisio, Correspondence to: Sanderson, e-mail: sanderson@uab.edu Keywords: heparanase, multiple myeloma, roneparstat, drug resistance, chemotherapy Received: July 28, 2015 Accepted:...
Chronic myeloid leukemia (CML) results from hematopoietic stem cell transformation by the BCR-ABL kinase. Despite success of tyrosine kinase inhibitors (TKIs) in treating CML patients, cells (LSCs) resist elimination and persist as a major barrier to cure. Previous studies suggest that overexpression sirtuin 1 (SIRT1) deacetylase may contribute LSC maintenance CML. Here, genetically deleting SIRT1 transgenic mice, we definitively demonstrated an important role for development. We identified...
Abstract: The HER-2/neu gene is a proto-oncogene that amplified in 10–30% of breast cancers. New drugs for targeted therapy, such as Herceptin, are effective patients with HER-2/neu-positive tumors, making it necessary to have noncostly and accurate method assess status. We studied the correlation findings made by fluorescent situ hybridization (FISH) immunohistochemistry (IHC) staining possibility combining IHC other clinicopathologic characteristics tumors predict FISH-determined analyzed...
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective this study to investigate the effects vascular endothelial growth factor receptor 1 (VEGFR1) blockade on complications DR. Experimental models diabetes were induced with streptozotocin (STZ) treatment or Insulin2 gene mutation (Akita) mice. Protein expression and localization examined by western blots (WB) immunofluorescence (IF). mRNA was quantified PCR array real-time PCR. activity VEGFR1...
E-cadherin (CDH1) is a glycoprotein that mediates adhesion between epithelial cells and also suppresses cancer invasion. Mutation or deletion of the CDH1 gene has been reported in 30-60% cases invasive lobular carcinoma (ILC). However, little known about genomic differences ILC with without alteration. Therefore, we analyzed whole genome sequencing data 169 from The Cancer Genome Atlas (TCGA) to address this deficiency. Our study shows was altered 59.2% (100/169) ILC. No significant...
We have begun an early phase of biomarker discovery in three clinically important types breast cancer using a panel human cell lines: HER2 positive, hormone receptor positive and negative, triple negative (HER2-, ER-, PR-). identified characterized the most abundant secreted, sloughed, or leaked proteins released into serum free media from these lines combination protein fractionation methods before LC-MS/MS mass spectrometry analysis. A total 249 were detected proximal fluid 7 lines. The...
Hepatocellular carcinoma (HCC) is one of the most fatal tumours worldwide and has a high recurrence rate. Nevertheless, mechanism HCC genesis remains partly unexplored, while efficiency treatments limited. The present study analysed expression nuclear receptor subfamily 4 group A member 1 (NR4A1) in tumour-infiltrating natural killer (NK) cells derived from both human patients with tumour-bearing mouse models, as well features NR4A1high NR4A1low NK cells. In addition, knockout NR4A1 by...
PURPOSE Therapy-related myeloid neoplasm (t-MN) is a life-threatening complication of autologous peripheral blood stem cell (PBSC) transplantation for non-Hodgkin lymphoma (NHL). Previous studies report an association between clonal hematopoiesis (CH) in PBSC and risk t-MN, but small samples precluded examination within specific subpopulations. METHODS Targeted DNA sequencing was performed to identify CH mutations from retrospective cohort 984 patients with NHL (median age at transplant, 57...
Chronic myeloid leukemia (CML) is propagated by stem cells (LSCs) that are not eradicated tyrosine kinase inhibitor (TKI) treatment and persist as a source of disease recurrence. Bone marrow (BM) mesenchymal niches play an essential role in hematopoietic cell (HSC) LSC maintenance. Using murine CML model, we examine leukemia-induced alterations populations. We show 6C3+ stromal progenitors expand BM exhibit increased but reduced HSC supportive capacity. Tumor necrosis factor alpha (TNF-α)...
Screening mammography is the most effective tool available for breast cancer detection. While screening saves lives, it has intrinsic problems that limit further improvement. We hypothesize protein biomarkers in nipple aspirate fluid (NAF) may separate from non-cancer state, and therefore can be used In this study proteins NAF were analyzed by surface-enhanced laser desorption ionization coupled to time-of-flight mass spectrometry (SELDI-TOF) m/z 5,000-85,000 range. Two methods normalize...
Protein-based markers that classify tumor subtypes and predict therapeutic response would be clinically useful in guiding patient treatment. We investigated the LC-MS/MS-identified protein biosignatures 39 baseline breast cancer specimens including 28 HER2-positive 11 triple-negative (TNBC) tumors. Twenty proteins were found to correctly all HER2 positive 7 of TNBC Among them, galectin-3-binding ALDH1A1 preferentially elevated TNBC, whereas CK19, transferrin, transketolase, thymosin 4 10...
The aim of this study was to assessment the efficacy and safety Programmed cell death protein 1 (PD-1)/Programmed death-Ligand (PD-L1) inhibitors plus anti-angiogenic agents with or without chemotherapy versus PD-1/PD-L1 as second later-line treatment for patients advanced non-small lung cancer.In study, pre-treatment clinical laboratory indicators from 73 cancer were retrieved retrospective analysis. According therapy regimes they received, separated into groups, group (PC group), agents'...
Abstract EML4‐ALK fusion genes have been recognized as novel “driver mutations” in a small subset of non‐small cell lung cancers (NSCLC). The frequency fusions NSCLC patients who clinical characteristics related to EGFR mutation remains unknown. We screened 102 Chinese with based on one or more the following characteristics: female, no light smoking history, and adenocarcinoma histology. were identified by RT‐PCR, whereas (Exons 18–21) KRAS 1 2) mutations detected DNA sequencing. Eight...