A5028832272- RNA Interference and Gene Delivery
- Blood groups and transfusion
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Salivary Gland Tumors Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- FOXO transcription factor regulation
- Muscle Physiology and Disorders
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Nanomaterials in Catalysis
- Endometrial and Cervical Cancer Treatments
- Pancreatitis Pathology and Treatment
- Mechanisms of cancer metastasis
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Immune Response and Inflammation
- Ear and Head Tumors
- Viral Infections and Vectors
- RNA and protein synthesis mechanisms
- Oral and Maxillofacial Pathology
- Ubiquitin and proteasome pathways
- Thyroid Cancer Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
Shandong University of Science and Technology
2024
Hunan Children's Hospital
2021-2024
City University of Hong Kong
2024
Jilin University
2015-2023
Guiyang College of Traditional Chinese Medicine
2017-2023
Zhengzhou University
2019-2022
Union Hospital
2015-2021
Jilin Medical University
2021
International AIDS Vaccine Initiative
2021
Nanjing University
2019-2020
Summary YWHAZ (14‐3‐3ζ) plays crucial roles in regulating proliferation, apoptosis, migration, and invasion of gastric cancer (GC) cells. However, its extensive potential mechanisms GC cells remain unknown, need to be researched deeply. In this study, we focus on the role miR‐375/YWHAZ axis epithelial‐to‐mesenchymal transition (EMT) level was assessed by western blot qPCR assays Scratch transwell were used determine migration The protein levels correlative molecules detected blot. regulation...
We identified a novel interactome, circ_0001018/miR-338-3p/SOX4, in papillary thyroid cancer (PTC), and we intended to confirm the regulatory relationship between three study effects of PTC. The bioinformatics method was used screen out circular RNA mRNA interest. A cellular fractionation assay fluorescence situ hybridization (FISH) were conducted prove that circ_0001018 CCT4 (the host gene circ_0001018) primarily localized cytoplasm PTC cell lines. By qRT-PCR analysis, expression SOX4 found...
YWHAZ (14-3-3ζ) has been reported to be a prognostic marker for various tumors and play crucial role in many oncogenic processes, including proliferation, migration invasion.However, the functional mechanism of gastric cancer (GC) are not detailed still require study.Herein, endogenous expression cell line BGC-823 was silenced by YWHAZ-specific short hairpin RNA (shRNA).Our data showed that silencing resulted cycle arrest cells.Further, YWHAZ-silenced cells acquired increased apoptosis rate,...
The use of combinatorial siRNAs shows great promise for drug discovery, but the identification safe and effective siRNA combinations remains challenging. Here, we develop a massively multiplexed technology systematic screening siRNA-based cocktail therapeutics. We employ composite micro-carriers that are responsive to near infrared light magnetic field achieve photoporation-facilitated transfection individual cells. Thus, randomized gene silencing by different formulations can be performed...
Salivary duct carcinoma (SDC) is a rare malignancy with high risk of local recurrence and distant metastases the salivary gland. This study was designed to summarize clinical pathological features further evaluate them as potential prognostic factors for SDC in gland.Clinical data 266 patients diagnosed between 2004 2015 were collected from Surveillance, Epidemiology, End Results (SEER) database. The affecting overall survival (OS) cancer-specific (CSS) determined by Kaplan-Meier analyses...
Although some breast cancer patients die due to tumor metastasis rather than from the primary tumor, molecular mechanism of remains unclear. Therefore, it is necessary inhibit during treatment. In this case, after designing and synthesizing CTI-2, we found that CTI-2 treatment significantly reduced cell in vivo vitro. Notably, with cells, expression level E-cadherin increased, while N-cadherin vimentin decreased. addition, treatment, those outflow levels for p-ERK, p-p38, p-JNK diminished,...
Objective . Lymphocytes are one of the main effector cells in inflammatory response acute pancreatitis (AP). The purpose study was to evaluate whether peripheral blood lymphocyte (PBL) subsets at admission change during AP based on clinical outcomes and explore these changes vary by aetiology AP. Hence, we performed a prospective find predictor that might allow easier, earlier, more accurate prediction outcomes. Methods Patients with were enrolled from December 2017 June 2018 First...
The treatment of breast cancer mainly relies on chemotherapy drugs, which present significant side effects. most typical example is the cardiotoxicity and bone marrow suppression associated with doxorubicin (DOX). Therefore, this drug not first choice in clinical treatment. We designed ATN-FFPFF-ATN, a new targeted antitumor carrier, polymerized from phenylalanine dipeptide (FF), ATN-161 peptide, Pluronic® F-127. peptide F-127 are linked acetal are, therefore, acid-sensitive. As can reduce...
Cell penetrating peptides (CPPs) are that can directly adapt to cell membranes and then permeate into cells. CPPs usually covalently linked the surface of nanocarriers endow their permeability whole system. However, hybrids with lipids or polymers make metabolism much more sophisticated even difficult determine. In this study, we present a continuous sequence 18 amino acids (FFAARTMIWY(d-P)GAWYKRI). It forms nanospheres around 170 nm, which increase slightly after loading siRNA DOX. Notably,...
Background: This study aimed to explore the clinical characteristics of noninfectious fever in patients with systemic lupus erythematosus (SLE) and underlying causes through multivariate analysis. Methods: Clinical data 128 SLE who were admitted Affiliated Hospital Nanjing University TCM, 210029, P.R. China from January 2015 December 2017 retrospectively analyzed. Results: The following factors closely associated fever: patient age, treatment history, SLEDAI score, enlarged liver, spleen...
Increased arterial stiffness is strongly associated with cardiovascular morbidity and mortality in dialysis patients. Ischemia-modified albumin (IMA) a useful biomarker of cardiac ischemia. This study was aimed to explore the association between IMA hemodialysis An observational conducted 120 Clinical data laboratory characteristics were collected. Arterial evaluated by brachial-ankle pulse wave velocity (baPWV). Hemodialysis patients had extensive high levels IMA. Comparing normal baPWV,...
Serum globulin is associated with inflammatory or immune disorders. However, it has not been established whether myasthenia gravis (MG). We investigated the association between relapse and prognosis in children MG.