A5101676806- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Educational Technology and Pedagogy
- Virus-based gene therapy research
- Ideological and Political Education
- Higher Education and Teaching Methods
- Toxic Organic Pollutants Impact
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Ion channel regulation and function
- Drug Solubulity and Delivery Systems
- Circular RNAs in diseases
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Advanced Thermoelectric Materials and Devices
- Neurotransmitter Receptor Influence on Behavior
- Computational Drug Discovery Methods
- Gold and Silver Nanoparticles Synthesis and Applications
- Carcinogens and Genotoxicity Assessment
- Axon Guidance and Neuronal Signaling
- Color perception and design
- Phagocytosis and Immune Regulation
Jiangsu University
2020-2024
Jiangsu Nhwa Pharmaceutical (China)
2023-2024
Fudan University
2018-2021
Environmental Health
2015
Tianjin Beichen Hospital
2011
California Department of Public Health
2011
Institute of Industrial Economics
2006
Zhejiang University
2005
Abstract Circular RNAs (circRNAs) play a crucial role in regulating various tumors. However, their biological functions and mechanisms gastric cancer (GC) have not been well understood. Here, we discovered stable cytoplasmic circRNA named circUSP1 (hsa_circ_000613) GC. CircUSP1 upregulation GC tissues was correlated with tumor size differentiation. We observed that promoted growth metastasis. Mechanistically, mainly interacted the RRM1 domain of an RNA-binding protein (RBP) called HuR,...
Drug resistance presents serious difficulties for cancer treatment. A combination of paclitaxel (PTX) and lapatinib (LAPA) shows potentials in multiple drug resistant cancers the clinic, but it is almost impossible to deliver these two drugs tumor at same time with best proportion by simple co-administration respective current formualtions their different pharmacokinetic profiles. Here composite nanocrystals PTX LAPA (cNC) were designed a ratio 2:1 (w/w), which was intracellular synergistic...
The dense extracellular matrix and high interstitial fluid pressure of tumor tissues prevent the ability anti-tumor agents to penetrate deep into parenchyma for treatment effects. C-end rule (CendR) peptides can enhance permeability blood vessels via binding neuropilin-1 (NRP-1), thus aiding in drug delivery. In this study, we selected one CendR (sequence RGERPPR) as parent l-peptide substituted d-amino acids l-amino synthesize its inverso peptide D(RGERPPR). We investigated NRP-1 activity...
Abstract Retro‐inverso bradykinin (RI‐BK) has better metabolic stability and higher affinity for the BK type 2 (B2) receptor, compared with bradykinin. At low doses, RI‐BK can selectively enhance permeability of blood–brain tumor barrier (BBTB) without harming normal brain tissue. In this study, gold nanoparticles (GNPs) size ranging from 5 to 90 nm are synthesized assess optimal nanocarriers that achieves maximum accumulation after treatment RI‐BK. The ability GNPs cross BBTB is tested in a...
Abstract Low transfection efficacy of non‐viral gene vectors restricts their applications. In this paper, N 1 ,N 3 ‐dicarbamimidoyl‐5‐methylisophthalamide (BGG) is designed as a functional group, in which two guanidyls are located at the meta positions an aryl ring. BGG conjugated with PAMAM G5 (G5‐BGG) and G5‐BGG/DNA complex dispersed into polyvinyl alcohol (PVA) hydrogel for local injection. Molecular docking, NMR, IR Isothermal titration calorimetry (ITC) experiments demonstrate that...
Gene therapy has become a potential strategy for cancer treatment. However, the development of efficient gene vectors restricts application Functionalization polymers with functional groups can significantly improve their transfection efficacy.Guanidyl form bidentate hydrogen phosphate and are present in DNA cell membranes, thus increasing condensation cellular uptake. Imidazolyl high buffering capacity endosomal/lysosomal acidic environment, facilitating endosome/lysosome escape. We...
Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that primarily managed by antidepressants lacking efficacy improving cognition. In this study, we report novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01 (a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative) exhibits both anti-depression effects improvements inhibits transporters (
2-Aminoimidazole greatly improved the transfection efficiency of G2. It contributes to condensing DNA into small, monodisperse nanostructures, enhancing cellular penetration and endosome/lysosome escape.
In this research, a variety of novel amphetamine derivatives were synthesized and assessed for their potential as multifaceted antidepressant agents. Among these compounds, compound
Miyun County was a main chestnut plantation in Beijing, China. The annual production of chestnuts 12,067.9 tons 2007, making up 54.1% the total Beijing. study summarized characters location, environment, distribution, nut quality and development Miyun, considered problems current industry put forward some suggestions to promote sustainable accelerate diversification economy.
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