A5037943586- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Nutrition and Health in Aging
- Platelet Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Salivary Gland Disorders and Functions
- Gastroesophageal reflux and treatments
- Frailty in Older Adults
- Renal function and acid-base balance
- Lipid metabolism and disorders
- Acute Kidney Injury Research
- Growth Hormone and Insulin-like Growth Factors
- Diverticular Disease and Complications
- Electrolyte and hormonal disorders
- Venous Thromboembolism Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Circular RNAs in diseases
- Esophageal and GI Pathology
- Cancer survivorship and care
- Immune Cell Function and Interaction
- Potassium and Related Disorders
- Gallbladder and Bile Duct Disorders
Tzu Chi University
2019-2025
Buddhist Tzu Chi Medical Foundation
2019-2023
University Gastroenterology
2023
Tzu Chi Foundation
2021-2022
Taipei Tzu Chi Hospital
2021
National Health Research Institutes
2019
Kaohsiung Veterans General Hospital
2017
Buddhist Tzu Chi General Hospital
2015
Abstract The effect of direct-acting antiviral agents (DAAs) on short-term platelet improvement in chronic hepatitis C (CHC) patients with thrombocytopenia is unclear. From December 2015 to March 2018, a total 249 CHC receiving DAA treatment baseline (platelet count <150 × 10 3 /μL) at Dalin Tzu Chi Hospital were enrolled this retrospective study. Blood examinations conducted (BL), week 4 (W4) after initiation, end (EOT), and 12 weeks EOT (P12). Hepatitis virus (HCV) genotyping revealed...
Although endoscopic papillary balloon dilation (EPBD) seems to cause fewer instances of bleeding, there are insufficient data determine the optimal methods for decreasing risk bleeding in cirrhotic patients.In this study, we compared risks following biliary sphincterotomy (EST) vs EPBD patients and identified clinical factors associated with 30-day mortality.Taiwan's National Health Insurance Database was used identify 3201 who underwent EST or between January 1, 2010, December 31, 2013.We...
Histamine-2-receptor antagonist (H2RA) has shown beneficial effects on the kidney, heart, and sepsis in animal models heart COVID-19 infection clinical studies. However, H2RAshave been used as a reference most epidemiological studies examining association of proton pump inhibitors (PPI) with outcomes. Therefore, we aimed to evaluate effect H2RA renal survival outcomes chronic kidney disease (CKD) patients. We Taiwanese nationalhealth insurance database from 2001 2016 screen 45,767 CKD...
Hepatitis C virus (HCV) infection is a potential risk factor for Sjögren's syndrome (SS). However, it unclear whether anti-HCV intervention therapy could decrease SS risk. A retrospective cohort analysis from 1997-2012 comprising 17,166 eligible HCV-infected adults was conducted. By 1:2 propensity score matching, total of 2123 treated patients and 4246 untreated were subjected to analysis. The incidence rates risks death evaluated through the end 2012. In follow-up 36,906 person-years, 177...
To clarify the predictive factors of significant platelet count improvement in thrombocytopenic chronic hepatitis C (CHC) patients. CHC patients with baseline counts <150 × 103/μL receiving direct-acting antiviral (DAA) therapy at least 12-weeks post-treatment follow-up (PTW12) were enrolled. Significant was defined as a ≥10% increase PTW12 from baseline. Platelet evolution treatment week 4, end-of-treatment, PTW12, and PTW48 evaluated. This study included 4922 Sustained virologic response...
Abstract The hepatitis C virus core antigen (HCV‐cAg) assay is a cheap and rapid alternative to HCV‐RNA detection, while the results were limited 12 weeks following direct‐acting antiviral (DAA) treatment. In this study we aimed investigate role of HCV‐cAg up 48 after DAA We enrolled 98 patients with chronic HCV infection who received treatment in study. Plasma samples assessed for (AmpliPrep/COBAS TaqMan assay, Roche) (Abbott ARCHITECT assay) levels at baseline, (P12) (P48) sensitivity...
Hepatitis B and C (HBV/HCV) coinfected patients have a potential risk of hepatitis reactivation (HBVr) after direct-acting antivirals (DAAs) treatment. The study intends to investigate the predictive role HBV biomarkers in HBVr. Forty-six HBV/HCV receiving DAAs were enrolled. All completed treatment follow-up 12th-week post-DAA (P12). Blood samples measured for biomarkers, including surface antigen (HBsAg), core-related (HBcrAg), pregenomic RNA (HBV pgRNA). factors HBVr DAA analyzed. Among...
Abstract Background Thrombocytopenia can rapidly improve in chronic hepatitis C (CHC) patients receiving direct-acting antiviral agents (DAA). The role of baseline (BL) thrombopoietin (TPO) this phenomenon is unclear. Methods From June 2016 to February 2019, a total 104 CHC DAA, with sustained virologic response and BL thrombocytopenia, at Dalin Tzu Chi Hospital, were enrolled retrospective study. Significant platelet count improvement ratio analyzed for correlation TPO. Results This cohort...
Abstract Hepatitis B virus (HBV) infection has been proposed to play a role in the development of Sjögren's syndrome. However, date, there are no reports on risk SS HBV‐infected patients following nucleos(t)ide analogue therapy. Due Taiwan higher prevalence HBV and therapy was well recorded Taiwan's single‐payer national health insurance database, we hypothesized that long‐term retrospective analysis syndrome nucleotide will increase our understanding infection. We identified 26,147 adults...
Clarithromycin-based therapy is important for Helicobacter pylori eradication treatment. However, clarithromycin may increase cardiovascular risk. Hence, we investigated the association between use and outcomes in adults with stable coronary heart disease (CHD) subsequent peptic ulcer (PUD).This nationwide cohort study used a national health insurance database to screen 298,417 Taiwanese residents who were diagnosed from 2001 2015 eligibility evaluate select eligible patients CHD-PUD 2004...
A 60-year-old man was hospitalized because of acute diverticulitis complicated with Bacteroides fragilis bacteremia. The computed tomography (CT) scan showed cecal superior mesenteric vein (SMV) thrombosis (Fig. 1). At that time, he received parenteral antibiotics for 2 weeks and then oral 1 week after discharge. Nine days later, presented to our emergency department progressive abdominal pain fever. CT demonstrated improved but local peritoneal inflammation around the SMV 2). upward arrow...
Summary Backgrounds Autoimmune pancreatitis (AIP) is a relatively rare disease and has similar presentations to pancreatic cancer. There are limited reports about this in Taiwan. Methods We retrospectively reviewed 14 cases of type 1 AIP from March 2007 2016 Kaohsiung Veterans General Hospital. The diagnosis was made according the international consensus diagnostic criteria (ICDC) for AIP. Results were 12 male two female patients diagnosed with AIP, mean age 63.6 (33 – 88) years. rates DM...
Abstract Background Thrombocytopenia can rapidly improve in chronic hepatitis C (CHC) patients receiving direct-acting antiviral agents (DAA). The role of baseline (BL) thrombopoietin (TPO) this phenomenon is unclear. Methods From June 2016 to February 2019, a total 104 CHC DAA, with sustained virologic response and BL thrombocytopenia, at Dalin Tzu Chi Hospital, were enrolled retrospective study. Significant platelet count improvement ratio analyzed for correlation TPO. Results This cohort...
Background Changes in renal function chronic hepatitis C (CHC) patients receiving direct-acting antivirals (DAAs) are controversial. The evolution of neutrophil gelatinase-associated lipocalin (NGAL) these remains unclear. Methods A total 232 CHC DAA at Dalin Tzu Chi Hospital from May 2016 to February 2019, were enrolled this retrospective study. Grade 2/3 deterioration, defined as a decrease eGFR between 10% and 50% baseline (BL) 12 weeks after the end treatment (P12), was investigated for...