A5103279051- Bladder and Urothelial Cancer Treatments
- Mesenchymal stem cell research
- Minimally Invasive Surgical Techniques
- Urological Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Surgical Simulation and Training
- Tissue Engineering and Regenerative Medicine
- Urinary and Genital Oncology Studies
- Anatomy and Medical Technology
- 3D Printing in Biomedical Research
- Palliative Care and End-of-Life Issues
- Urinary Bladder and Prostate Research
- Angiogenesis and VEGF in Cancer
- Pelvic floor disorders treatments
- Testicular diseases and treatments
- Electrospun Nanofibers in Biomedical Applications
- Abdominal Surgery and Complications
- Reconstructive Surgery and Microvascular Techniques
- Glaucoma and retinal disorders
- Appendicitis Diagnosis and Management
- Ureteral procedures and complications
- Ear and Head Tumors
- Retinal Diseases and Treatments
- Patient Dignity and Privacy
- Metastasis and carcinoma case studies
Boston Children's Hospital
2024-2025
Harvard University
2007-2025
University of Louisville
2012-2024
Brigham and Women's Hospital
2018-2024
Cardiovascular Innovation Institute
2012-2017
Jewish Hospital
2015
VCU Massey Comprehensive Cancer Center
2009
Virginia Cancer Institute
2009
University of Oxford
2007
Massachusetts Institute of Technology
2007
One of the major challenges in cell implantation therapies is to promote integration microcirculation between implanted cells and host. We used adipose-derived stromal vascular fraction (SVF) vascularize a human liver (HepG2) implant. hypothesized that SVF would form functional via assembly inosculation with host vasculature. Initially, we assessed extent character neovasculatures formed by freshly isolated cultured found have higher vascularization potential. Generation 3D implant...
To report the outcomes of active surveillance (AS) for low-risk prostate cancer (PCa) in a single-center cohort.This is prospective, single-center, observational study. The cohort included all patients who underwent AS PCa between December 1999 and 2020 at our institution. Follow-up appointments (FU) ended February 2021.A total 413 men were enrolled study, 391 had least one FU. Of those followed up, 267 diagnosed by transrectal ultrasound (TRUS)-guided biopsy (T1c: 68.3%), while 124 after...
Abstract Acquiring sufficient amounts of high-quality cells remains an impediment to cell-based therapies. Induced pluripotent stem (iPSC) may be unparalleled source, but autologous iPSC likely retain deficiencies requiring correction. We present a strategy for restoring physiological function in genetically deficient utilizing the low-density lipoprotein receptor (LDLR) deficiency Familial Hypercholesterolemia (FH) as our model. FH fibroblasts were reprogrammed into using synthetic modified...
Introduction: The increasing adoption of robotic-assisted cystectomy with intracorporeal urinary diversion (ICUD), despite its complexity, prompts a detailed comparison extracorporeal (ECUD). Our study at single institution investigates perioperative outcomes and identifies risk factors impacting the success these surgical approaches. Methods: In this retrospective analysis, 174 patients who underwent University Louisville from June 2016 to August 2021 were reviewed. cohort was divided into...
Follow-up is essential for the early detection of recurrent non-muscle invasive bladder cancers (NMIBC). This study investigates clinical relevance new diagnostic tools such as an mRNA-based urine test (XPERT© Bladder Cancer Monitor, XBCM) and Narrow Band Imaging© (NBI) compares them with established follow-up diagnostics (white-light cystoscopy (WLC) cytology). was a prospective, double-blind, single-center that involved patients undergoing NMIBC screening at tertiary care center....
The microvasculature is principally composed of two cell types: endothelium and mural support cells. Multiple sources are available for human endothelial cells (ECs) but microvascular (MCs) limited. We derived multipotent mesenchymal progenitor from embryonic stem (hES-MC) that can function as an MC stabilize EC networks in three-dimensional (3D) collagen-fibronectin culture by paracrine mechanisms. Here, we have investigated the basis hES-MC-mediated stabilization identified pleiotropic...
Multimodal therapy has improved survival in genitourinary rhabdomyosarcoma, a rare pediatric cancer. However, little is reported regarding postoperative complications and long-term urinary sexual function quality of life.We reviewed records from 1970-2018 to identify patients with rhabdomyosarcoma the bladder, prostate, pelvis, vagina, uterus. We assessed modes therapy, if surgical, type resection, reconstruction, reoperation. Primary outcomes included continence, tract infection occurrence,...
9539 Background: Many seriously ill cancer patients do not discuss prognosis or advance directives (ADs), which may lead to aggressive care at end of life (Harrison & Smith, JAMA 2008). Ten years ago, did want ADs with their oncologist (ONC), but would them an admitting doctor (Lamont JPM 2000).We assessed if this still held. Methods: We administered semi-structured interviews inpatients on the VCUHS Hematology-Oncology service. 55/63 consecutive accrued. Information was collected...
In this paper, we describe the development and evaluation of a novel tissue-holding device (THD) for use during robotic-assisted laparoscopic partial nephrectomy. The THD is vacuum-based apparatus made either 3D-printed polyethylene or stainless steel. proximal end connects to suction tubing routed outside body, while distal conically shaped designed firmly interface with tumor. Device feasibility studies were performed on six porcine kidneys, two livers, embalmed human cadavers. A...