The pumpkin seed oil obtained from Cucurbita pepo has been shown to be useful for the treatment of nocturia in patients with urinal disorders several western countries. In this study, we evaluated effect maxima on urinary dysfunction human overactive bladder (OAB). Forty-five subjects were enrolled study. An extract C. (10 g oil/day) was orally administrated 12 weeks. After 6 and weeks, function using Overactive Bladder Symptom Score (OABSS). Pumpkin significantly reduced degree OABSS...

The extract from roasted chicory (Cichorium intybus L.; jú jù) root (chicory extract), which contains inulin-type fructans, has favorable effects including antihyperglycemic and antidyslipidemic the improvement of bowel movement. In this study, we examined on blood glucose, lipid metabolism, fecal properties in 47 healthy adult participants a randomized, double-blind, placebo-controlled study. were divided into test group that drank placebo nonchicory (ingesting 300 mL daily for 4 weeks). We...

Rutin, a phenolic compound, has antioxidant, anti-dyslipidaemic, and body weight-reducing effects. We evaluated the anti-arteriosclerotic, effects of rutin-rich Tartary buckwheat. randomly divided 144 adult subjects into an active test food group consuming products containing buckwheat placebo group. Body composition measurements haematological urine tests were performed at weeks 0, 4, 8, 12, 3 after termination. Atherosclerosis index ox-LDL did not significantly differ between groups....

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter with beneficial effects including antihypertension and antistress properties. In this study, we examined the of GABA-enriched white rice (GABA rice) on blood pressure (BP) in 39 mildly hypertensive adults a randomized, double-blind, placebo-controlled study. The participants were divided into test group (n = 22) who consumed 11.2 mg GABA/100 g placebo 17) 2.7 rice. For 8 weeks, took 150 either GABA or Hematological examinations...

Quercetin, which is frequently found in vegetables such as onion, widely to have biological activities visceral fat reduction. Therefore, we performed this randomised double-blind placebo-controlled parallel-group study and analysed the effects of daily intake quercetin-rich onion on for 12 weeks. Seventy healthy Japanese subjects whose body mass index (BMI) was ≥23 <30 were recruited randomly assigned either group or placebo group. The ingested 9 g powder per day We conducted medical...

Quercetin is a polyphenol found in food that has numerous health benefits. This study investigated the relationship between quercetin metabolism, gut microbiota composition, and dietary intake elderly Japanese subjects. A frequency questionnaire was used to assess during week prior stool sample collection. Fecal suspensions from 56 subjects were anaerobically incubated with fecal composition analyzed by next-generation sequencing. Inter-individual variations concentration at family level...

To elucidate the effects of Lilac LAB (Bacillus coagulans lilac-01 and okara [soy pulp] powder) on bowel movements/fecal properties, we conducted a double-blind placebo-controlled randomized trial with healthy Japanese volunteers tendency for constipation (n = 297). The subjects ingested 2 g/d placebo (okara or test food (Lilac LAB, 1 × 10(8) CFU) once day weeks. In group functionally constipated subjects, changes in average scores self-reported fecal size, sensation incomplete evacuation,...

Quercetin, a type of flavonoid, is believed to reduce age-related cognitive decline. To elucidate its potential function, we carried out randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial involving 24-week continuous intake quercetin-rich onion compared quercetin-free as placebo. Seventy healthy Japanese individuals (aged 60 79 years old) were enrolled in this study. We examined the effect (the active test food) on function using Mini-Mental State...

Lactobacillus plantarum HOKKAIDO (HOKKAIDO strain) was isolated from well-pickled vegetables in Hokkaido, Japan. We report a randomized, double-blind, placebo-controlled study evaluating the effects of L. on immune function and stress markers 171 adult subjects. Subjects were divided into three groups: yogurt group, placebo-1 group who ingested without strain, placebo-2 yogurt-like dessert strain. Hematological tests body composition measurements performed before after 4 8 weeks blinded...

Pleurotus cornucopiae (Oyster mushroom, Tamogitake) has long been eaten as a functional food for enhancement of the immune system, but its effectiveness not well confirmed in humans. To this end, we set up double-blind placebo-controlled human clinical trial to investigate potential Oyster mushrooms with respect up-regulation system. The subjects ingested mushroom extract 8 weeks. We measured serum cytokine levels involved regulation including interferon (IFN)-γ, interleukin (IL)-4, IL-5,...

The green tea (Camellia sinensis L.) cultivar &ldquo;Sunrouge&rdquo; contains anthocyanins, catechins and flavonols. To determine whether ingesting containing anthocyanins improves visual function blood pressure (BP) in healthy adults, a randomized, double-blind, placebo-controlled study was performed. A total of 120 subjects, aged between 20 60 years with systolic BP (SBP) value &le;125 <155 diastolic (DBP) <95, or DBP &le;75 mmHg <95 SBP mmHg, were randomly assigned to one three groups....

Tomato (Solanum lycopersicum) is a rich source of lycopene, carotenoid that confers various positive biological effects such as improved lipid metabolism. Here, we conducted randomized, double-blind, placebo-controlled, parallel-group comparative study to investigate the regular and continuous intake new high-lycopene tomato, variety named PR-7, for 12 weeks, based on 74 healthy Japanese subjects with low-density lipoprotein cholesterol (LDL-C) levels ≥120 &lt;160 mg/dL. The were randomly...

Background: Lactobacillus gasseri strain SBT2055 (LG2055) is a human intestine-originating probiotic bacterium and potent known to exert various health promotion effects, including prevention of abdominal adiposity in rats humans. A recent finding mice has suggested that oral administration LG2055 induces protective effect against influenza virus infection. In this context, evidence for efficacy using clinical trial was imminently required.Methods: To confirm humans, randomized,...

Salmon milt peptide is a novel food material that shows dipeptidyl peptidase-IV inhibitory activity and can be expected to suppress postprandial hyperglycaemia in subjects without insulin resistance.

Background: Quercetin, a phenolic compound, has various functional effects, including anti-oxidant, anti-dyslipidaemic and anti-dysglycemic activities, beneficial effects on cognitive function.Methods: We evaluated the of powder made from quercetin-rich onions (‘Quergold’ ‘Sarasara-gold’) function. In this randomised, double-blind, placebo-controlled study, we randomised 50 adults (25 males 25 females, aged 65–84 years) to consume products (active) or quercetin-poor (placebo) onions....

Adlay has been used as a traditional Chinese medicine and nutrient for its beneficial effects on bowel movements skin care. This study examined the effect of enzymatic degradation product adlay, "Super Hatomugi" (SPH) human intestinal flora in randomized, double-blind placebo-controlled study. The subjects were divided into three groups: 500 mg SPH, 1000 placebo, taken daily 4 weeks. Hematological condition examinations well an analysis performed 2 weeks before 10 after start SPH intake....

Soybean is recognized as a beneficial food with various functional components, such β-conglycinin, which improves lipid metabolism. We evaluated the effects of β-conglycinin-rich soybean Nanahomare on triglyceride (TG) levels. In this randomized, double-blind, placebo-controlled study, we divided 134 adult subjects into test and placebo groups that consumed processed containing enriched-β-conglycinin or low-β-conglycinin soybean. Hematological tests body composition measurements were...

Eggplant (Solanum melongena) is a globally popular vegetable and its significant health effect has not been reported in randomized controlled trials. Recently, we that eggplant was rich choline esters, including acetylcholine (ACh), had an antihypertensive spontaneously hypertensive rats. Here, evaluated the effects of continuous intake powder on blood pressure (BP), stress, psychological state (PS) 100 stressed participants with normal-high BP or grade 1 hypertension randomized,...

穀物GABA富化装置を用いてGABA含有量を富化した北海道米「ゆめぴりか」を材料に,最適な富化処理条件の設定とヒトへの抗ストレス効果を検証した.精白米のGABA含有量,炊飯米の官能評価および香気成分分析から,最適な富化処理時間を3時間と定めた.次に,プラセボ(通常の精白米)を対照とした10週間の二重盲検並行群間試験を実施した.被験者は39名であった(被験食群22名,プラセボ食群17名).VASテストの結果から,GABA富化米の摂取により精神状態と睡眠の質が改善される傾向が見られた.また,コルチゾールとアディポネクチンの血中濃度から,GABA富化米の摂取によりストレス負荷が軽減される傾向が見られた.以上より,3時間の富化処理下で製造したGABA富化米は,ストレス負荷を緩やかに軽減させる効果を有する可能性が示唆された.

Scallop oil (SCO) prepared from the internal organs of Japanese giant scallop (Patinopecten yessoensis) contains eicosapentaenoic acid (EPA), docosahexaenoic (DHA), and phospholipids (PL). It was previously shown that SCO consumption improves cholesterol triacylglycerols (TG) contents in mice. The present study demonstrated effects daily (1.2 g/day, containing 376 mg EPA, 63 DHA, 150 PL) for 12 weeks human subjects. In this randomized, doubleblind, placebo-controlled, parallel group...