A5064739851- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Advanced X-ray Imaging Techniques
- Digital Holography and Microscopy
- Optical measurement and interference techniques
- Neurobiology of Language and Bilingualism
- Molecular Sensors and Ion Detection
- Receptor Mechanisms and Signaling
- Remote Sensing and Land Use
- Liver Disease Diagnosis and Treatment
- Environmental Changes in China
- Parkinson's Disease Mechanisms and Treatments
- Advanced Electron Microscopy Techniques and Applications
- Adaptive optics and wavefront sensing
- Language, Metaphor, and Cognition
- Orbital Angular Momentum in Optics
- RNA regulation and disease
- Matrix Theory and Algorithms
- Reading and Literacy Development
- Hepatocellular Carcinoma Treatment and Prognosis
- Environmental and Agricultural Sciences
- Liver physiology and pathology
- Educational Technology and Pedagogy
- Digital Media Forensic Detection
- Mathematical Inequalities and Applications
Jiangxi Academy of Environmental Sciences
2023-2025
Jiangxi Provincial Institute of Water Sciences
2009-2025
Yunnan Open University
2025
Chinese PLA General Hospital
2025
Chinese People's Liberation Army
2025
Shanghai Institute of Optics and Fine Mechanics
2018-2024
Chinese Academy of Sciences
2024
Hohai University
2010-2023
Zhongshan Hospital of Xiamen University
2023
Fudan University
2023
Abstract During the onset of liver fibrosis, capillarized sinusoidal endothelial cells (LSECs) limit substance exchange between blood and Disse space, further accelerating hepatic stellate cell (HSCs) activation fibrosis progression. Limited accessibility therapeutics to space is often overlooked remains a major bottleneck for HSCs‐targeted therapy in fibrosis. Here, an integrated systemic strategy treatment reported, utilizing pretreatment with soluble guanylate cyclase stimulator,...
Glutamate transporters play a key role in glutamate clearance and protect the central nervous system from excitotoxicity. Dysfunctional contribute to pathogenesis of Parkinson's disease (PD); however, mechanisms that underlie regulation PD are still not well characterized. Here we report Nedd4-2 mediates ubiquitination 1-methyl-4- phenylpyridinium (MPP+)-treated astrocytes midbrain 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-constructed model mice. Nedd4-2-mediated induces abnormal...
Parkinson's disease (PD) is a common neurodegenerative that characterized by pathological dopaminergic (DA) neuronal death and α-synuclein aggregation. Glutamate excitotoxicity well-established pathogenesis of PD involves dysfunctional expression glutamate transporters. transporter-1 (GLT-1) mainly responsible for clearance at synapses, including DA synapses. However, the role GLT-1 in aberrant synaptic transmission remains elusive. In present study, we generated small-interfering RNAs...
Abstract This paper provides an in-depth study and optimisation of the teaching methods vocational education teachers with help artificial intelligence. In field machine learning, article develops a small-scale knowledge graph. Then, combined constructed graph, recommendation algorithm integrating student interest connectivity is proposed, learner are defined in whole design process system. Based on model, AI-assisted method for proposed terms content, learning situation, methods,...
Surface soil moisture (SSM) plays a pivotal role various fields, including agriculture, hydrology, water environment, and meteorology. To investigate the impact of land use types fractional vegetation cover (FVC) on accuracy SSM estimation, this study conducted comprehensive analysis estimation performance across diverse scenarios (e.g., multiple combinations cropland) varying FVC conditions. Sentinel-2 NDVI MOD09A1 were fused by Enhanced Spatial Temporal Adaptive Reflection Fusion Model...
Abstract Extreme ultraviolet (EUV) light is difficult to focus due strong absorption of most materials. Photon sieves (PS), rather than Fresnel zone plates (FZP), can EUV smaller spot and suppress the higher orders secondary maxima by several magnitude. The number pinholes used in PS far more that transparent rings FZP, providing a great flexibility manipulate structured focusing EUV. In this work we investigate Fermat-spiral produce focused vortices with different topological charges....
Porcine circovirus type 2 (PCV2) is the primary causative agent that causing porcine circovirus-associated disease (PCVAD). The open reading frame 5 (ORF5) protein a newly discovered non-structural in PCV2, which function viral pathogenesis remains unknown. aim of this study was to investigate mechanism PCV2 ORF5 on autophagy and replication. pEGFP-tagged gene ectopic expressed PK-15 cells an ORF5-deficient mutant strain (PCV2ΔORF5) were used infected cells. This demonstrated essential for...
Autonomous obstacle avoidance technology is the best way to embody feature of robot strong intelligence in intelligent navigation system. In order solve problem autonomous mobile robot, an model used this paper. Adopting multi-sensor data fusion and algorithm based on fuzzy control, a design system S3C2410X described. Its perceptual composed nine ultrasonic sensors detect surrounding environment from different angles, enhancing reliability redundant between sensors, expanding performance...
The digital elevation model (DEM) and its derivative attributes are important parameters for evaluating any process using terrain analysis. Five freely available global DEM products including Advanced Spaceborne Thermal Emission Reflection Radiometer-Global Digital Elevation Model version 2 (ASTER GDEM2), Shuttle Radar Topographic Mission 4.1 (SRTM V4.1), Global Multiresolution Terrain Data 2010 (GMTED2010), EarthEnv-DEM90, 30 Arc-Second (GTOPO30) were assessed in this study. objective of...
Currently, platinum-containing regimens are the most commonly used for advanced gastric cancer patients, and chemotherapy resistance is one of main reasons treatment failure. Thus, it important to reveal mechanism oxaliplatin seek effective intervention strategies improve sensitivity, thereby improving survival prognosis patients. To understand molecular mechanisms resistance, we generate an oxaliplatin-resistant cell line conduct assay transposase-accessible chromatin sequencing (ATAC-seq)...
Non-photochemical quenching (NPQ) is an indicator of crop stress. Until now, only a limited number studies have focused on how to estimate NPQ using remote sensing technology. The main challenge the complicated regulatory mechanism NPQ. can be divided into energy-dependent (qE) and non-energy-dependent (non-qE) quenching. contribution these two components varies with environmental factors, such as light intensity stress level due different response mechanisms. This study aims explore...
Abstract Excitatory amino acid transporter 2 (EAAT2), also known as glial glutamate type 1 (GLT-1), plays an important role in maintaining the extracellular concentrations below neurotoxic levels. The highly conserved TM2 transmembrane domain of GLT-1 maintains a stable position during transport cycle; however, effect cycle on topology TM4 not well established. To further reveal function TM4, two cysteine pairs between and were introduced using site-directed mutagenesis. A significant...
The brain tumor segmentation task with different domains remains a major challenge because tumors of grades and severities may show distributions, limiting the ability single model to label such tumors. Semi-supervised models (e.g., mean teacher) are strong unsupervised domain-adaptation learners. However, one main drawbacks using teacher is that given large number iterations, weights converge those student model, any biased unstable predictions carried over student. In this article, we...
During daily conversations, people prefer indirect replies in face-threatening situations. Existent studies have indicated that recipients tend to perceive the information conveyed by as negative and emotion regions are engaged processing In this study, we examined whether can reduce recipients' experience of what underlying cerebral structures may give rise individual differences effectiveness such attenuating emotion. Behavior ratings resting-stating functional magnetic resonance imaging...