A5017508309- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Disease and Adiposity
- Traumatic Brain Injury and Neurovascular Disturbances
- Protease and Inhibitor Mechanisms
- Orthopedic Surgery and Rehabilitation
- Infectious Diseases and Tuberculosis
- Facial Nerve Paralysis Treatment and Research
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Genetic Associations and Epidemiology
- Blood Coagulation and Thrombosis Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Glaucoma and retinal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebral Venous Sinus Thrombosis
- Hereditary Neurological Disorders
- Peripheral Nerve Disorders
- Neurological Disorders and Treatments
- Hemoglobinopathies and Related Disorders
Fujian Medical University
2019-2025
First Affiliated Hospital of Fujian Medical University
2019-2025
Importance: Acute ischemic stroke patients due to intracranial internal carotid artery (ICA) occlusion often have poor functional outcomes despite endovascular treatment (EVT). Objective: To investigate the efficacy and safety of intravenous methylprednisolone as adjunct EVT for with ICA occlusion. Design, Setting, Participants: This was a post-hoc analysis MARVEL randomized, double blind, placebo-controlled clinical trial conducted from February 2022 June 2023 at 82 centers across China....
Importance Patients with acute ischemic stroke (AIS) due to intracranial internal carotid artery (ICA) occlusion often have poor functional outcomes despite undergoing endovascular thrombectomy (EVT). Objective To investigate the effectiveness and safety associated intravenous methylprednisolone as adjunctive treatment EVT for patients AIS ICA occlusion. Design, Setting, Participants This was a post hoc analysis of MARVEL randomized, double-blind, placebo-controlled clinical trial conducted...
<title>Abstract</title> <bold>Background: </bold>The relationship between Inflammatory Bowel Disease (IBD) and Bell’s palsy remains unsubstantiated. This study aims to investigate the causal IBD palsy. <bold>Methods:</bold> Using two-sample Mendelian randomization (MR) method explore We applied summary statistics from GWAS for 91 inflammatory proteins FinnGen R10 International Genetics Consortium. <bold>Results: MR indicates a significant positive association (OR: 1.13, 95% CI [1.03 1.23], P...
Abstract Objectives To investigate the relationships between 18 single nucleotide polymorphisms with carotid atherosclerosis and whether interactions among these genes were associated an increased risk of atherosclerosis. Methods Face‐to‐face surveys conducted individuals aged 40 or older in eight communities. A total 2377 included study. Ultrasound was used to detect population. loci 10 inflammation endothelial function detected. Gene‐gene analyzed using generalized multifactor...
Background The relationship between hemoglobin concentration and stroke has garnered significant interest in the research community. However, findings from published observational epidemiological studies on this have been inconclusive. By using publicly available genome-wide association study (GWAS) aggregated statistics, a two-sample Mendelian randomization analysis is conducted to explore causal stroke. Methods Summary statistics data UK Biobank for FinnGen R9 MEGASTROKE consortium are...
This study aims to retrospectively evaluate the association between pericarotid inflammation and presence of embolic stroke undetermined source (ESUS).In total, 126 patients with ESUS 118 ischemic from large artery atherosclerosis (LAA) were enrolled. All underwent brain MRI a neck CT angiography (CTA) examination. Reviewers blinded infarct location cause. Paired t-tests assessed within-subjects differences in mean Hounsfield units (HUs) carotid perivascular fat cerebral infarction side...
Abstract Objectives To investigate the association of eight variants four matrix metalloproteinase (MMP) genes with ischemic stroke (IS) and whether interactions among these single nucleotide polymorphisms (SNPs) increases risk IS. Methods Among 547 patients 350 controls, matrix‐assisted laser desorption/ionization time flight mass spectrometry was used to examine arising from different genes, including MMP‐1 (rs1799750), MMP‐2 (rs243865, rs2285053, rs2241145), MMP‐9 (rs17576), MMP‐12...
The mechanisms of ischemic stroke severity and early neurologic deterioration (END) are not fully understood. aim the present study was to investigate association six variants in MMP-9 gene with risk for END (IS) patients atrial fibrillation (AF).This a multi-center, prospective, observational 615 acute IS AF admitted participating hospitals between June 2016 October 2017. Ischemic assessed using National Institutes Health Stroke Scale (NIHSS) score on admission. defined as an increase four...
The optic nerve sheath diameter (ONSD)/eyeball transverse (ETD) ratio has been suggested in the evaluation of intracranial pressure (ICP). aim this study was to evaluate predictive value ONSD and ONSD/ETD relation risk for secondary malignant middle cerebral artery infarction (MMI).A total 91 patients with MCA occlusion were included study. Data divided into two groups based on development MMI or not. ETD measured by unenhanced computed tomography (CT). differences ratios between non-MMI...
Abstract Objectives The purpose of this study was to investigate the impact single nucleotide polymorphisms (SNPs) in ANGPTL4 gene and SNP–SNP interactions on atherosclerotic ischemic stroke (IS) risk. Patients methods A case-control conducted. total 360 patients with IS 342 controls between December 2018 2019 from Longyan First Hospital affiliated Fujian Medical University were included. logistic regression model used examine association SNPs Odds ratios (ORs) 95% confidence intervals (95%...
Carpal tunnel syndrome (CTS) is a common symptom of nerve compression and leading cause pain hand dysfunction. However, the underlying biological mechanisms are not fully understood. The aim this study was to reveal causal effect circulating metabolites on susceptibility CTS.
Abstract Background Current research suggests inflammation as a cause of Bell's palsy. However, large number patients have not fully recovered even after combined antiviral and glucocorticoid treatment. Consequently, the relationship between palsy remains uncertain. Methods We employed two-sample Mendelian randomization approach using genetic variances from UK Biobank (626cases 361,141 controls European ancestry) inflammatory cytokines GWAS summary containing 8,293 healthy participants. took...