A5042395456- Genetics, Aging, and Longevity in Model Organisms
- Entomopathogenic Microorganisms in Pest Control
- Trace Elements in Health
- Selenium in Biological Systems
- Insect symbiosis and bacterial influences
- Insect Resistance and Genetics
- Heavy Metal Exposure and Toxicity
- Insect and Arachnid Ecology and Behavior
- Viral Infectious Diseases and Gene Expression in Insects
- Nematode management and characterization studies
- Circadian rhythm and melatonin
- Insect behavior and control techniques
- Mechanisms of cancer metastasis
- Evolution and Genetic Dynamics
- Ecosystem dynamics and resilience
- DNA Repair Mechanisms
- Plant Diversity and Evolution
- Plant and Fungal Species Descriptions
- Bioactive natural compounds
- Sperm and Testicular Function
- Microtubule and mitosis dynamics
- Phytochemical Studies and Bioactivities
- Digestive system and related health
- Genomics, phytochemicals, and oxidative stress
- Marine and environmental studies
University College London
2025
Washington University in St. Louis
2013-2024
California Institute of Technology
1935-2024
University of Santo Tomas
2020
Duke Medical Center
2013
First Hospital of Jilin University
2013
Jilin University
2013
University of Portsmouth
2013
National Taiwan University
2012
Fudan University
1989
The following mutant strains of D. pseudoobscura were used: (I) yellow, singed, vermilion, compressed, short (y, sn, v, CO, sh), ( 2 ) orange (or), (3) purple (or pr), (4) white w , (5) aristapedia (ast), and (6) Bare Curly (Ba Cy).Mutants affecting different parts the body are included in this list: a color yellow; eye mutants orange, purple, white; bristle singed Bare; wing Curly; an antenna aristapedia.With exception Curly, which dominant lethal when homozygous, all other recessive viable...
The nematode intestine is the primary site for nutrient uptake and storage as well synthesis of biomolecules; lysosome-related organelles known gut granules are important many these functions. Aspects biology not understood, including export nutrients it imports molecules synthesizes, complete functions protein content granules. Here, we report a mass spectrometry (MS)–based proteomic analysis Caenorhabditis elegans its Overall, identified approximately 5,000 proteins each in gonad showed...
Zinc is an essential nutrient—it stored during periods of excess to promote detoxification and released deficiency sustain function. Lysosome-related organelles (LROs) are evolutionarily conserved site zinc storage, but mechanisms that control the directional flow necessary for homeostasis not well understood. In Caenorhabditis elegans intestinal cells, CDF-2 transporter stores in LROs excess. Here, we identify ZIPT-2.3 as releases deficiency; transports zinc, localizes membrane release from...
As an entomopathogenic nematode (EPN), Steinernema hermaphroditum parasitizes insect hosts and harbors symbiotic Xenorhabdus griffinae bacteria. In contrast to other Steinernematids, S. has hermaphroditic genetics, offering the experimental scope found in Caenorhabditis elegans . To enable biological analysis of , we have assembled analyzed its reference genome. This genome assembly five chromosomal scaffolds 83 unassigned totaling 90.7 Mb, with 19,426 protein-coding genes having a BUSCO...
The phenomenon of neglected adolescents is more common than people thought both nationally and internationally. Family environment own ecological system can affect their mental health learning efficiency. Neglected encounter social-emotional challenges, yet prior research often overlooks the factors influencing development. Few studies systematically integrate social, family, school to comprehensively understand outcomes. This systematic literature review assesses on development from an...
Sperm activation is a fascinating example of cell differentiation, in which immotile spermatids undergo rapid and dramatic transition to become mature, motile sperm. Because the sperm nucleus transcriptionally silent, this does not involve transcriptional changes. Although Caenorhabditis elegans leading model for studies activation, mechanisms by signaling pathways induce transformation remain poorly characterized. Here we show that conserved transmembrane zinc transporter, ZIPT-7.1,...
Collecting full network data is often infeasible, costly, or limited by privacy concerns. Aggregated Relational Data (ARD), where researchers collect the number of connections to different groups, can sometimes save over 80complete ...Collecting complete expensive, time-consuming, and infeasible. which ask respondents questions form “How many people with trait X do you know?” provide a low-cost option when collecting ...
Nuclear receptors were originally defined as endocrine sensors in humans, leading to the identification of nuclear receptor superfamily. Despite intensive efforts, most have no known ligand, suggesting new ligand classes remain be discovered. Furthermore, are encoded genomes primitive organisms that lack signaling, primordial function may been environmental sensing. Here we describe a novel Caenorhabditis elegans receptor, HIZR-1, is high zinc sensor an animal and master regulator...
Abstract Entomopathogenic nematodes (EPNs), including Heterorhabditis and Steinernema, are parasitic to insects contain mutualistically symbiotic bacteria in their intestines (Photorhabdus Xenorhabdus, respectively) therefore offer opportunities study both mutualistic symbiosis. The establishment of genetic tools EPNs has been impeded by limited tractability, inconsistent growth vitro, variable cryopreservation, low mating efficiency. We obtained the recently described Steinernema...
The entomopathogenic nematode Steinernema hermaphroditum was recently rediscovered and is being developed as a genetically tractable experimental system for the study of previously unexplored biology, including parasitism its insect hosts mutualism with bacterial endosymbiont Xenorhabdus griffiniae. Through whole-genome re-sequencing genetic mapping we have first time molecularly identified gene responsible mutationally defined phenotypic locus in an nematode. In process observed unexpected...
is the only identified entomopathogenic nematode that consistently hermaphroditic and thus offers a great opportunity to use genetic approaches probe symbiosis. Evolutionarily, ecologically, morphologically distinct from laboratory nematodes commonly used in laboratory, with both forward reverse genetics tools available, this species also provides an explore other areas of biology, especially using comparative studies. Here, we describe improved solid medium-based culturing method for
Abstract The biological roles of the autofluorescent lysosome-related organelles (“gut granules”) in intestinal cells many nematodes, including Caenorhabditis elegan s, have been shown to play an important role metabolic and signaling processes, but they not fully characterized. We report here a previously undescribed phenomenon which autofluorescence these granules increased then decreased rapid dynamic manner that may be associated with nutrient availability. observed two distinct types...
Programmed cell death (apoptosis) is essential for the development and homeostasis of metazoans. The central step in execution programmed activation caspases. In C. elegans, core regulators EGL-1(a BH3 domain-containing protein), CED-9 (Bcl-2), CED-4 (Apaf-1) act an inhibitory cascade to activate CED-3 caspase. Here we have identified additional component eif-3.K (eukaryotic translation initiation factor 3 subunit k) that acts upstream ced-3 promote death. loss reduced deaths both somatic...
Cell adhesion plays essential roles in almost every aspect of metazoan biology. LINKIN (Human: ITFG1, Caenorhabditis elegans: lnkn-1) is a conserved transmembrane protein that has been identified to be necessary for tissue integrity during migration. In C. elegans, loss lnkn-1 results the detachment lead migratory cell from rest developing male gonad. Previously, three interactors ITFG1/lnkn-1 - RUVBL1/ruvb-1, RUVBL2/ruvb-2, and alpha-tubulin were by immunoprecipitation-mass spectrometry...
Abstract The entomopathogenic nematode Steinernema hermaphroditum was recently rediscovered and is being developed as a genetically tractable experimental system for the study of previously unexplored biology, including parasitism its insect hosts mutualism with bacterial endosymbiont Xenorhabdus griffiniae . Through whole-genome re-sequencing genetic mapping we have first time molecularly identified gene responsible mutationally defined phenotypic locus in an nematode. In process observed...
Sperm activation is a rapid and dramatic cell differentiation event that does not involve changes in transcription, the signaling cascades mediate this process have been fully defined. zipt-7.1 encodes zinc transporter, zipt-7.1(lf) mutants display sperm-activation defects, leading to hypothesis mediates sperm Caenorhabditis elegans. Here, we describe development of method for dynamic imaging labile during using zinc-specific fluorescence probe FluoZin-3 AM time-lapse confocal imaging. Two...