A5065813020- HIV/AIDS Research and Interventions
- Adolescent and Pediatric Healthcare
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- LGBTQ Health, Identity, and Policy
- Palliative Care and End-of-Life Issues
- Sex work and related issues
- Syphilis Diagnosis and Treatment
- Global Maternal and Child Health
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Impact and Responses
- Maternal Mental Health During Pregnancy and Postpartum
- Poverty, Education, and Child Welfare
- Neuroendocrine regulation and behavior
- Homelessness and Social Issues
- Animal Behavior and Reproduction
- Down syndrome and intellectual disability research
- Mindfulness and Compassion Interventions
- Gestational Diabetes Research and Management
- Interprofessional Education and Collaboration
- Chronic Disease Management Strategies
- Animal Behavior and Welfare Studies
University of Maryland, Baltimore
2010-2025
University of Maryland, College Park
2019
Jacksonville University
2004
Vanderbilt University
1981-1982
Summary: The authors sought to assess the utility of electronic Medication Event Monitoring System (MEMS) in monitoring adherence highly active antiretroviral therapy (HAART) HIV-infected children and compare this with other methods assessment. Twenty-six perinatally being treated three or more medications their caregivers were enrolled prospectively followed-up for 6 months. Adherence was assessed using MEMS one antiretroviral, pharmacy refill records all antiretrovirals, a caregiver...
Outcomes following healthcare transition (HCT) from pediatric to adult HIV care are not well described. We sought describe clinical outcomes HCT within our institution among young adults with behavioral-acquired (N = 31) and perinatally-acquired 19) HIV. conducted a retrospective cohort study HIV-infected who attempted institution. The primary end point was retention in care, defined as the completion of at least two visits over 12 months linkage care. Additional points include time changes...
BACKGROUND: We sought to determine if HIV-exposed uninfected (HEU) children had worse neurodevelopmental outcomes at 24 months compared with HIV-unexposed (HUU) in Botswana. METHODS: HIV-infected and mothers enrolled a prospective observational study (“Tshipidi”) Botswana from May 2010 July 2012. Child neurodevelopment was assessed the Bayley Scales of Infant Toddler Development, Third Edition (Bayley-III: cognitive, gross motor, fine expressive language, receptive language domains)...
Scores from the Alcohol Use Disorders Identification Test (AUDIT) and Center for Epidemiological Studies Depression Scale (CES-D) administered to both antiretroviral therapy (ART)-experienced -naive adults in HIV care Nigeria were evaluated association with participant characteristics ART adherence measured by pharmacy records. Participants included 222 ART-experienced 177 ART-naive adults, of whom 47 (12%) had AUDIT ≥8, 29 (7%) an ≥10, 52 (13%) a CES-D ≥16, 25 (6%) ≥21. An elevated score...
The role of experience in the development huddling preferences and sibling recognition by spiny mouse (Acomys cahirinus) weanlings was investigated. In 1st experiment, pups separated from their littermates fostered onto unfamiliar females (and offspring) on day birth, Day 10, or 20, subsequently showed preferential with foster littermates. Huddling biological siblings as infrequent unrelated, agemates. 2nd study revealed that mother may play a ontogeny recognition, possibly through...
This study examines the relationship between adherence to pediatric HIV regimens and three family experience factors: (1) regimen responsibility; (2) barriers adherence; (3) strategies for remembering give medications. Caregivers of 127 children ages 2-15 years in PACTS-HOPE multisite were interviewed. Seventy-six percent caregivers reported that their adherent (taking > or = 90% prescribed doses within prior 6 months). Most taking primary responsibility medication-related activities...
Objectives Despite being at a heightened risk of HIV, the use pre-exposure prophylaxis (PrEP) among adolescents remains low, which may stem from access to this biomedical intervention and comfort providers caring for priority population. Prior studies evaluating knowledge related PrEP have focused on adult or been conducted prior FDA approval adolescents. This study focuses pediatric providers' regarding counseling prescribing Materials methods Two anonymous surveys were administered...
Although parents and caregivers may have primary responsibility for their children's medication- taking, surprisingly few studies examined caregiver psychosocial correlates of adherence to antiretroviral therapy (ART). This cross-sectional, descriptive study the relationship between characteristics medication among children with HIV. Fifty-four HIV completed a demographic questionnaire, Parenting Stress Index, Brief Symptom Inventory, Family Support Scale, Functions Scale. Adherence ART was...
This paper presents findings of a multi-site study designed to document: (1) caregivers' regimen knowledge; (2) barriers adherence; and (3) the relationships between adherence, knowledge barriers. Fifty-one predominantly female, African American parents caregivers HIV-infected children completed Treatment Interview Protocol (TIP), brief, structured interview assess adherence. TIP data were compared information obtained from medical records pharmacy refill histories. Forty-nine per cent...
The HIV latent reservoir in resting memory CD4+ T cells precludes cure. Therapeutics to reactivate and eliminate this are clinical trials adults, but not yet pediatric populations. We determined, ex vivo, the inducibility of perinatal infection as compared with adult infections using Tat/rev induced limiting dilution assay (TILDA), which a single round (12 hours) cell stimulation PMA/ionomycin maximally activates leads proviral expression multiply spliced RNA production. Markers immune...
Background. Neurodevelopmental impairment has been identified in children infected with human immunodeficiency virus (HIV). The frequency and spectrum of neurologic are greater than those reported for adults. In children, HIV is known to enter the central nervous system early course disease. presentation pediatric neuro-acquired immune deficiency syndrome ranges from static (eg, nonprogressive developmental delay) progressive encephalopathy acquired microcephaly, pyramidal tract signs,...
Objective: Conflicting data exist regarding the impact of in-utero exposure to maternal combination antiretrovirals. We compared neurodevelopmental outcomes between HIV-exposed-uninfected (HEU) children exposed in utero three-drug antiretroviral therapy (ART) vs. zidovudine (ZDV) monotherapy. Design: Prospective study child neurodevelopment, nested within two cohorts HIV-infected mothers and their Botswana (one observational, one interventional). Methods: The Tshipidi Mma Bana studies...
Adolescents and young adults living with HIV (YLHIV) face numerous stresses that affect their care medication adherence. The clinic social environment may play an important supportive role for YLHIV, influencing health outcomes. aim of this article is to explore how YLHIV in Baltimore, Maryland understand the various forms support provided within clinic. We used qualitative research methods including iterative, semi-structured in-depth interviews 20 interviewed up three times each stressors,...
Objective Examine the 24-hr Recall Interview (24RI) for assessing children’s antiretroviral medication adherence. Methods Caregivers of 54 children with HIV (aged 2–12 years) completed a clinical adherence interview and 24RI by telephone. Children’s viral load 3-month pharmacy records were obtained. Results Thirty-seven percent missed ≥1 dose medicine over 3 days. In 22% samples, varied across medications. The scores (Frequency, Interval, Dietary Adherence) moderately reliable three...
Human immunodeficiency virus pre-exposure prophylaxis (PrEP) clinical guidelines recommend men who have sex with (MSM) PrEP users be screened biannually for syphilis and gonorrhea/chlamydia at all anatomic sites. We sought to determine the proportion positive by STI site initiation PrEP-care visits patient-level characteristics associated screening among MSM in Baltimore City, Maryland.Medical records initiating between 30 September 2015 31 March 2018 were abstracted. (syphilis sites)...
Adolescents and young adults (AYA) 13–24 years old make up a disproportionate 21% of new HIV diagnoses. Unfortunately, they are less likely to treat effectively, with only 30% achieving viral suppression, limiting efforts interrupt transmission. Previous work mindfulness-based stress reduction (MBSR) has shown promise for improving treatment in AYA living (AYALH). This randomized controlled trial compared MBSR general health education (HT). Seventy-four 13–24-year-old AYALH conducted...
This study sought to examine predictors of psychological symptoms and psychiatric service receipt among youth with HIV. Data were from the baseline assessment Adolescent Impact, a 13-21-year-old HIV in three US cities. Between August 2003 February 2005, participants completed age-appropriate or adult self-report symptom checklists (Achenbach system empirically based assessment) reported their treatment history. Psychiatric diagnoses abstracted medical records. The 164 participating living...
Medication adherence is critical for children's HIV treatment success, but obtaining accurate assessments challenging when complex measurement technologies are not feasible. Our goal was to evaluate a multidimensional interview designed improve on existing measures. Data from caregivers (N = 126) of perinatally infected children were analyzed determine the ability revised guide detect potential nonadherence. Questions related viral load (VL) bivariate level included proportion doses taken in...
Pediatric neuro-AIDS may be the first clinical manifestation of HIV infection in children born to infected mothers. As part neurodevelopmental examination children, Clinical Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS) was investigated as a tool for pediatricians use monitor development at risk infection. The CAT/CLAMS found detect differences between HIV-infected uninfected 12 18 months age. Good correlations were concurrently administered Bayley Scales Infant...
In three studies, core temperatures of immature chicks rose during immobilization induced by simulated predation and fell rapidly when terminated. Immobilization termination was predicted proximity the temperature to daily resting adult fowl. Although duration increased with age shorter in cold hot environments, terminated at same all ages ambient temperatures. The common pattern change across Ss suggests that is response demand rising be behaviorally maintained within a vital range....
Background: In utero exposure to nucleoside reverse transcriptase inhibitor (NRTI)-containing antiretroviral treatment (ART) regimens may be associated with poor neurodevelopmental functioning in children of HIV-infected mothers. We investigated outcomes HIV-exposed uninfected (HEU) women enrolled a randomized trial abacavir/zidovudine/lamivudine (triple-NRTI regimen) vs. lopinavir/ritonavir/zidovudine/lamivudine [dual-NRTI + protease (PI) regimen]. Setting: The Mma Bana was conducted urban...
Summary Children infected with the human immunodeficiency virus (HIV) are living longer. Studies aimed at understanding health and well‐being of these children as they age into adolescence enhanced by research designs that include appropriate comparison groups. HIV‐exposed but uninfected one such group; however, recruitment this group is challenging because may no longer be followed tertiary care centres, some in foster or their biological parents. This paper describes methods, sampling...