A5080646516- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Substance Abuse Treatment and Outcomes
- Pulmonary Hypertension Research and Treatments
- Network Security and Intrusion Detection
- Antiplatelet Therapy and Cardiovascular Diseases
- Anomaly Detection Techniques and Applications
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Islanding Detection in Power Systems
- Machine Learning in Materials Science
- Mental Health Research Topics
- Cardiovascular Function and Risk Factors
- Power Systems and Technologies
- Power Systems Fault Detection
- Liver Disease and Transplantation
- Prenatal Substance Exposure Effects
- Machine Learning in Healthcare
- Smart Grid and Power Systems
- DNA Repair Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024
Ernst Ruska Centre
2023
University of Pittsburgh
2016-2020
National Institute on Drug Abuse
2016-2019
Shenzhen Stock Exchange
2019
Genomics (United Kingdom)
2016-2018
Discovery Institute
2016-2017
Wuhan University
2006
Abstract Identifying the molecular targets for beneficial effects of active small-molecule compounds simultaneously is an important and currently unmet challenge. In this study, we firstly proposed network analysis by integrating data from pharmacology metabolomics to identify components in sini decoction (SND) against heart failure. To begin with, 48 potential SND failure were predicted serum pharmacochemistry, text mining similarity match. Then, employed including docking these components....
Tumor necrosis factor α (TNF-α) is overexpressed in various diseases, and it has been a validated therapeutic target for autoimmune diseases. All therapeutics currently used to TNF-α are biomacromolecules, limited numbers of chemical inhibitors have reported, which makes the identification small-molecule alternatives an urgent need. Recent studies mainly focused on identifying small molecules that directly bind or TNF receptor-1 (TNFR1), inhibit interaction between TNFR1, and/or regulate...
Abstract Sotatercept is a breakthrough, first‐in‐class biologic, that FDA‐approved for the treatment of pulmonary arterial hypertension (PAH). A population pharmacokinetic (PopPK) model was developed using data from two phase 1 studies in healthy participants, and 2 one 3 study participants with PAH. The pooled sotatercept PK encompassed single intravenous (IV) or subcutaneous (SC) doses ranging 0.01 to 3.0 mg/kg, as well multiple SC 0.03 1.0 samples collected up maximum ~150 weeks following...
What is known and Objective Although ticagrelor has been well-known to improve clinical outcomes in patients undergoing percutaneous coronary intervention (PCI), its effectiveness safety have not well evaluated Chinese patients. This study aimed evaluate the of In order find potential effect modifiers on drug effects, a decision tree method was performed detect interactions between treatment patient characteristics an automatic systematic manner. Methods retrospective included acute syndrome...
Abstract Introduction We investigated the effect of antihypertensive (aHTN) medications and cholinesterase inhibitors (ChEIs) on cognitive decline in patients with Alzheimer's disease (AD) analyzed synergism by chemogenomics systems pharmacology mapping. Methods compared aHTN drugs Mini‐Mental State Examination scores 617 AD hypertension, studied synergistic effects. Results The combination diuretics, calcium channel blockers, renin‐angiotensin‐aldosterone system blockers showed slower other...
Traumatic brain injury (TBI) is associated with high mortality and morbidity. Though the death rate of initial trauma has dramatically decreased, no drug been developed to effectively limit progression secondary caused by TBI. TBI appears be a predisposing risk factor for Alzheimer's disease (AD), whereas molecular mechanisms remain unknown. In this study, we have conducted research investigation computational chemogenomics systems pharmacology (CSP) identify potential targets treatment....
Sotatercept is a breakthrough, first‐in‐class biologic, recently approved by the Food and Drug Administration (FDA) for treatment of pulmonary arterial hypertension (PAH). Exposure‐response (E‐R) analyses pharmacokinetic/pharmacodynamic (PK/PD) modeling were performed sotatercept after intravenous subcutaneous (SC) administrations. Clinical endpoints included 6‐minute walk distance (6MWD), vascular resistance (PVR), probability N‐terminal pro‐B natriuretic peptide (NT‐proBNP) concentrations...
Due to the complex structure and changeable operation mode, distribution network frequently suffers from various types of damage (such as line break faults). Among them, single-line fault feature is not obvious, conventional detection method difficult monitor effectively low reliability. In order solve this problem, a real time monitoring for based on dual-terminal information proposed in paper. By relevant voltage current signals power supply side load time, extracting information,...
To explore the association between DNA damage-related genetic variants and lung cancer susceptibility in a Han Chinese population.This case-control study enrolled patients from Cancer Hospital of Jiangsu Province 2003 to 2009. Controls were randomly selected individuals who visited same hospital or community-based health examination program during time period. A 5 ml venous blood sample was obtained each participant epidemiological information collected on standard questionnaire. Illumina...
This paper focuses on the data cleaning of electric industrial control terminal. First, we introduce isolation forest algorithm for locating dirty data. In order to improve detection accuracy higher dependent in power system, is modified. Second, use BP neural network predict To optimize performance, genetic introduced optimizing weight network. Finally, provide a case study illustrating effectiveness proposed method.
Assessment tests for glycemic control of patients with diabetes mellitus commonly use blood glucose and glycated hemoglobin A1C (HbA1C) levels estimating acute long-term glycemia, respectively. Diabetes diet, as well treatment, are adapted accordingly also the risk diabetic complications can be estimated. Glycated human serum albumin (GHSA) has been proposed an alternative to HbA1C since it possesses a four times shorter lifespan its concentration is not affected by hemic diseases. Here,...
This paper presents a framework of data mart integrating the prevailing power distribution dispatching automation system. In framework, is key link component systems. used to system into an integrated and it can help create decision support circumstance for makers. (4 pages)
Power system intelligent terminal equipment is widely used in real-time monitoring, data acquisition, power management, distribution and other tasks of smart grid. The can obtain various information users companies the grid, but there still a lack protection means for connection communication process components. In this paper, novel method based on improved deep belief network(IDBN) proposed to accomplish business-level security monitoring attack detection terminal. A non-intrusive platform...