A5034202078- Spaceflight effects on biology
- High Altitude and Hypoxia
- Immune Response and Inflammation
- Medical and Biological Ozone Research
- Pediatric health and respiratory diseases
- Human Health and Disease
- Biochemical effects in animals
- Thermoregulation and physiological responses
- Immune responses and vaccinations
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Anesthesia and Neurotoxicity Research
- Exercise and Physiological Responses
- Climate Change and Health Impacts
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Herpesvirus Infections and Treatments
- Vitamin D Research Studies
- Alkaline Phosphatase Research Studies
- Digestive system and related health
- Bone Metabolism and Diseases
- Children's Physical and Motor Development
- Reproductive tract infections research
- Biofield Effects and Biophysics
- Immunotherapy and Immune Responses
Institute of Biomedical Problems
2019-2025
The complex of spaceflight factors has a significant impact on the immunity functional activity. This influence is probably caused by such as isolation, monotony, physical inactivity, sensory deprivation, and increased psycho-emotional tension. Long-term wintering at polar stations can be ground-based model that most similar to space flight conditions. research focused examining reactivation latent human pathogens among 11 participants 64th Russian Antarctic expedition Vostok station....
Space flight factors are known to cause a malfunction in the human immune system and lead damage blood vessels. The hemostatic function of endothelium during space missions its interaction with immunity has not been determined so far. In this work, we investigated markers endothelial activation (plasma concentrations soluble thrombomodulin fraction (sTM), von Willebrand factor (vWF), highly sensitive C-reactive protein (hs-CRP)), as well level D-dimer compared them immunological parameters...
The next steps of deep space exploration are manned missions to Moon and Mars. For safe for crew members, it is important understand the impact flight on immune system. We studied effects 21 days dry immersion (DI) exposure transcriptomes T cells isolated from blood samples eight healthy volunteers. Samples were collected 7 before DI, at day 7, 14, during after DI. RNA sequencing CD3+ revealed transcriptional alterations across all time points, with most changes occurring 14 DI exposure. At...
During space missions cosmonauts are exposed to a myriad of distinct stressors such as radiation, overloads, weightlessness, isolation in artificial environmental conditions, which causes changes immune system. flights it is very difficult determine the particular factor associated with observed immunological responses. This makes ground-based experiments examining effect each flight along value. Determining mechanisms causing alterations cosmonauts' immunity can lead potential targets for...
The paper presents data of the investigations subclinical reactivation 7 human herpes viruses and bacteria Mycoplasmahominis, Ureaplasmaurealiticum Chlamydiatrachomatis from 6 participants in a 14-day isolation study conducted small chamber with controlled environment. Purpose analysis was to establish correlations between DNAs latent viral bacterial pathogens bio-liquids organism indices natural adaptive immune system. It determined that short-term may provoke both nature. events can be...
The authors present the results of studying processes involved in maturation dendritic cells (DCs) derived from CD14+-monocytes and TCR-activation peripheral blood lymphocytes 9 ISS Russian crew members. It was demonstrated that long-term habitation on low Earth's orbits brings about disorders both DCs Т-lymphocytes evidenced by reductions mature expressing В7 family co-stimulating molecules also positive CD28 co-stimulation. investigation found an increased number tolerogenic with...
Expression of inborn immunity genes was studied in 10 essentially healthy male subjects aged 24 to 32 years a 21-day dry immersion experiment without countermeasures. To evaluate the humoral function, encoding Toll-like receptors, proteins mediating NF-kB, AP-1, Akt, TLR4; apoptosis proteins, and CLEC4E, HSPD1, PTGS2 were selected. Fenol-cloroform extraction used obtain total RNA from peripheral blood monocytes CD14+. Subsequently, reverse transcribed generate cDNA for real-time PCR. The...
Here, we report the changes in expression of TLR-associated genes, genes NF-kB, AP-1, and TLR4 pathways, coding for apoptotic proteins, cytokines, chemokines, after rotation on short-arm centrifuge. The study involved 10 almost healthy male volunteers aged 25-40. CD14+ monocytes were isolated from testers’ blood before exposure to artificial gravity. cells incubated with TLR1-9 ligands 24 hours assess monocytes’ reserve potential. gene was evaluated by real-time PCR. In sum, no negative...
The complex of space flight (SF) factors can have a negative impact on the human organism, including innate and adaptive immunity. One effects impaired functional activity immune system is decrease latent infections immunological control. During short- long-term SF, reactivation viruses was shown, while virus detected in body fluids for some time after returning to Earth. Despite fact that most cases asymptomatic, there are fears during long expeditions into deep space, pathogens lead...
Показатели клеточного иммунитета человека в условиях создания искусственной гравитации с помощью центрифуги короткого радиуса 1 Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации Институт медико-биологических проблем академии наук, Министерство и высшего образования
Влияние дыхательных гипоксических газовых смесей (кислородно-азотной и кислородно-азотно-аргоновой) в условиях барокамеры на показатели клеточного иммунитета человекаФедеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации -Институт медико-биологических проблем академии наук
Влияние дыхательных гипоксических газовых смесей (кислородно-азотной и кислородно-азотно-аргоновой) в условиях барокамеры на показатели клеточного иммунитета человекаФедеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации -Институт медико-биологических проблем академии наук
Aim. This work was undertaken to assess the effect of 120-day isolation conditions in a sealed compartment with an artificial habitat on formation microbiocenosis and system signaling image-recognizing receptors Toll-like (TLR) family innate immunity.Materials methods. The microflora intestine upper respiratory tract, as well content monocytes granulocytes expressing TLRs (TLR1, TLR2, TLR4, TLR6, TLR9) peripheral blood, basal production cytokines (IL-1β, IL-6, IL-8, IL-10, TNF-α) by...
Innate immunity was investigated in six 28 to 44 y.o. volunteers for 120-d isolation controlled environment. Peripheral blood samples gathered during were analyzed determine monocytes and granulocytes expressing intracellular (TLR3, TLR8, TLR9) surface (TLR1, TLR2, TLR4, TLR5, TLR6) TLRs, lymphocytes-natural killers (CD3-CD16+CD56+). The system of pattern-recognition cell receptors displayed a heterogenic reaction with primary activation throughout the period isolation. observed changes...