A5058584816- Spaceflight effects on biology
- Human Health and Disease
- Thermoregulation and physiological responses
- Stress Responses and Cortisol
- High Altitude and Hypoxia
- Heart Rate Variability and Autonomic Control
- Body Composition Measurement Techniques
- Cannabis and Cannabinoid Research
- Vestibular and auditory disorders
- Biochemical effects in animals
- Space Exploration and Technology
- Ophthalmology and Eye Disorders
- Cardiovascular and exercise physiology
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Vitamin D Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Physical Education and Training Studies
- Circadian rhythm and melatonin
- Exercise and Physiological Responses
- Advanced MRI Techniques and Applications
- Renal function and acid-base balance
- Technology and Human Factors in Education and Health
- Bluetooth and Wireless Communication Technologies
- Diet and metabolism studies
Institute of Biomedical Problems
2012-2024
Russian Academy of Sciences
2004-2014
Space flight exerts a specific conglomerate of stressors on humans that can modulate the immune system. The mechanism remains to be elucidated and consequences for cosmonauts in long term are unclear. Most current research stems from short-term spaceflights as well pre- post-flight analyses due operational limitations. Immune function 12 participating long-duration (>140days) spaceflight mission was monitored pre-, post-, two time-points in-flight. While classical markers stress such...
The endocannabinoid system (ECS) plays an important role in the regulation of physiological functions, from stress and memory to vegetative control immunity. ECS is considered a central peripheral response emotional or physical challenges acts through endocannabinoids (ECs), which bind their receptors inducing subsequent effecting mechanisms. In our studies, responses have been assessed blood concentrations ECs anandamide 2-arachidonoylglycerol. parallel, saliva cortisol was determined...
Abstract Environmental factors have long been known to influence immune responses. In particular, clinical studies about the association between migration and increased risk of atopy/asthma provided important information on role associated large sets environmental exposures in development allergic diseases. However, investigations effects responses are mostly limited candidate exposures, such as air pollution. The influences still largely unknown. A simulated 520-d Mars mission an...
The aim of the study was to evaluate effects long-term confinement on stress-permissive neuroendocrine and immune responses in humans. Two groups four male subjects were confined 240 days ( group 240) or 110 110) two space modules 100 200 m 3 , respectively. During confinement, none volunteers developed psychic stress as could be examined verified by a current test. However, g roup but not 110, diurnal rhythm cortisol secretion slightly depressed urine excretion norepinephrine significantly...
The innate immune system as one key element of immunity and a prerequisite for an adequate host defense is emerging interest in space research to ensure crew health thus mission success. In ground-based studies, spaceflight-associated specifics such confinement caused altered functions paralleled by changes stress hormone levels. this study, six men were confined 105 days module ~500 m(3) mimicking conditions long-term mission. Psychic was surveyed different questionnaires. Blood, saliva,...
Space flight factors are known to cause a malfunction in the human immune system and lead damage blood vessels. The hemostatic function of endothelium during space missions its interaction with immunity has not been determined so far. In this work, we investigated markers endothelial activation (plasma concentrations soluble thrombomodulin fraction (sTM), von Willebrand factor (vWF), highly sensitive C-reactive protein (hs-CRP)), as well level D-dimer compared them immunological parameters...
The review presents the results of studying hemocoagulation system in Soviet and Russian experiments modeling effects some spaceflight factors on human organism. most adequate models microgravity are head-down bed rest (BR) immersion. Effects g-loads were reproduced by rotation a centrifuge. In course these experiments, procoagulant, anticoagulant fibrinolytic activities displayed different trends dependence period locomotion reduction. immersion, procoagulant activity increased, decreased...
Negative pressure breathing is with decreased in the respiratory tract without lowering acting on torso. We lowered only during inspiration (NPBin). NPBin used to increase venous return heart and considered as a countermeasure against redistribution of body fluids toward head spaceflight. Aims our study were: obtain quantitative information NPBin-induced changes parameters circulation respiration healthy human at various rarefactions; identify main processes involved cardiorespiratory response NPBin.
The paper presents the results of investigations devoted to construction information systems for wireless monitoring distributed parameters (in particular, medical parameters). Special emphasis is placed on interface methods in such systems, using heterogeneous network technologies. implementing a system prototype based networking standard IEEE 802.15.4 are discussed. this testing MARS−500 project, simulating work spacesuit after landing astronauts surface planet, presented.