A5018411866- Spaceflight effects on biology
- SARS-CoV-2 and COVID-19 Research
- Cystic Fibrosis Research Advances
- Stress Responses and Cortisol
- High Altitude and Hypoxia
- Climate Change and Health Impacts
- COVID-19 Clinical Research Studies
- Bacterial biofilms and quorum sensing
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Genetics, Aging, and Longevity in Model Organisms
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- Asthma and respiratory diseases
- Aquaculture Nutrition and Growth
- Sodium Intake and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune Response and Inflammation
- Legume Nitrogen Fixing Symbiosis
- Tracheal and airway disorders
- Mycobacterium research and diagnosis
- Cannabis and Cannabinoid Research
- Dermatology and Skin Diseases
- Antibiotic Resistance in Bacteria
TU Dresden
2020-2024
University Hospital Carl Gustav Carus
2020-2024
Institute of Medical Microbiology and Hygiene
2020-2021
LMU Klinikum
2014-2016
Ludwig-Maximilians-Universität München
2014-2016
München Klinik
2015
Chungbuk National University
2011-2014
Max Planck Society
2009
Max Planck Institute for Developmental Biology
2007
Seoul Medical Center
2000
Chronic Pseudomonas aeruginosa infections play an important role in the progress of lung disease patients suffering from cystic fibrosis (CF). Recent studies indicate that polymicrobial microbiome profiles airway are associated with less inflammation. Thus, hypothesis was raised certain commensal bacteria might protect host We therefore performed a screening study commensals isolated CF samples to identify potential beneficial commensals. more than 80 aerobic or facultative anaerobic...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution plays a significant role in shaping the dynamics of disease 2019 pandemic. To monitor SARS-CoV-2 variants, through international collaborations, we performed genomic epidemiology analyses on weekly basis with samples collected from border region between Germany, Poland, and Czech Republic global background. For identified virus mutant active viruses were isolated functional evaluations to test their replication fitness...
Breathing allows a multitude of airborne microbes and microbial compounds to access the lung. Constant exposure pulmonary microenvironment immunogenic particles illustrates need for proper control mechanisms ensuring differentiation between threatening harmless encounters. Discrimination live dead bacteria has been suggested be such mechanism. In this study, we performed infection studies murine precision cut lung slices (PCLS) with or heat-killed P. aeruginosa, in order investigate role...
In cystic fibrosis (CF), Pseudomonas aeruginosa infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the of distinct polymicrobial lung infections is largely unknown. this study, we aimed identify commensal bacteria may inhibit growth P. aeruginosa. Through screening study more than 80 CF strains across 21 species, 30 from various species have been identified The underlying...
Abstract In spite of three-year pandemic time caused by Covid-19, the trend and impact evolution SARS-CoV-2 remain unclear. For newly emerging variants, it is still hard to predict how possibly they could pandemic/endemic course. The spreading highly transmissible variant XBB.1.5 JN.1 has brought many questions. Could high transmission ability such lead a different global pattern compared other previously existing variants concern (VOCs)? How that may affect further SARS-CoV-2? This study...
Abstract Environmental factors have long been known to influence immune responses. In particular, clinical studies about the association between migration and increased risk of atopy/asthma provided important information on role associated large sets environmental exposures in development allergic diseases. However, investigations effects responses are mostly limited candidate exposures, such as air pollution. The influences still largely unknown. A simulated 520-d Mars mission an...
The innate immune system as one key element of immunity and a prerequisite for an adequate host defense is emerging interest in space research to ensure crew health thus mission success. In ground-based studies, spaceflight-associated specifics such confinement caused altered functions paralleled by changes stress hormone levels. this study, six men were confined 105 days module ~500 m(3) mimicking conditions long-term mission. Psychic was surveyed different questionnaires. Blood, saliva,...
Pseudomonas spp. exhibit considerable differences in host specificity and virulence. Most species were isolated exclusively from environmental sources, ranging soil to plants, but some have been detected versatile including both human sources. Understanding genome variations that generate the tremendous diversity biology is important controlling incidence of infections. With a data set 704 complete whole sequences representing 186 species, intrageneric structure was investigated by...
Loss of FLG causes ichthyosis vulgaris. Reduced expression compromises epidermal barrier function and is associated with atopic dermatitis, allergy, asthma. The flaky tail mouse harbors two mutations that affect the skin barrier, Flgft, resulting in hypomorphic expression, Tmem79ma, inactivating TMEM79. Mice defective only for TMEM79 featured dermatitis systemic atopy, but also Flgft/ft BALB/c congenic mice developed eczema, high IgE, spontaneous asthma, suggesting protects from atopy. In...
The human immune system is orchestrated in a complex manner and protects the host against invading organisms controls adequate responses to different antigen challenges an endo-, auto- paracrine-regulated fashion. variety intensity of are known be dependent on stress-sensitive neural, humoral metabolic pathways. delayed-type hypersensitivity (DTH) skin test was validated standardized measure applied clinical studies monitor integral function cellular vivo. DTH was, however, phased out 2002....
Abstract In Germany, Eastern regions had a mild first wave of coronavirus disease 2019 (COVID-19) from March to May 2020, but were badly hit by second later in autumn and winter. It is unknown how the was initiated developed Germany where number COVID-19 cases close zero June July 2020. We used genomic epidemiology investigate dynamic severe acute respiratory syndrome 2 (SARS-CoV-2) lineage development across waves Germany. With detailed phylogenetic analyses we could show that SARS-CoV-2...
Long-term treatment with azithromycin is a therapeutic option in Cystic Fibrosis (CF) patients chronically infected P. aeruginosa. It was recently shown that has direct antimicrobial activity when aeruginosa isolates are tested Roswell Park Memorial Institute medium supplemented fetal calf serum (RPMI 1640/FCS) by broth microdilution. We now investigated whether (i) might also be active against multidrug resistant (MDR) isolated from CF and (ii) how vitro sensitivity assays perform synthetic...
The Hox gene lin-39 plays a crucial role in the establishment of nematode vulva equivalence group. Mutations Caenorhabditis elegans and Pristionchus pacificus result vulvaless phenotype because presumptive precursor cells adopt non-vulval fates. Interestingly, fate anterior posterior epidermal differs between Pristionchus; C. elegans, fuse with hypodermis, whereas, P. pacificus, they die as programmed cell death. (Cel-lin-39) indirectly controls fusion eff-1 by regulating GATA transcription...
SUMMARY PAX3 is a member of the PAX3/7 subfamily paired box proteins. In vertebrates, Pax3 essential for skeletal myogenesis by activating cascade transcriptional events that are necessary and sufficient myogenesis. Four related basic helix‐loop‐helix transcription factors, MyoD, Myf5, Mrf4, Myogenin, targets serve as myogenic regulatory factors. Although role in well studied little known about invertebrate PAX‐3 proteins Here, we took advantage viable alleles pax‐3 nematode satellite model...
Abstract In cystic fibrosis (CF), infections with Pseudomonas aeruginosa or other typical pathogens play a critical role in eliciting disease progression, leading to tissue damage and finally loss of lung function. Previous observations showed that the presence various commensal bacteria higher airway microbiome diversity were associated better function less severe burden. Thus, hypothesis was raised might be able interfere pathogenic bacteria. this study, we aimed identify inhibit growth P....
Although endocrine-disrupting chemicals (EDC) may interfere with the endocrine system(s) of animals and humans have an estrogenicity or androgenicity, exact mechanism(s) underlying their detrimental effects is not clearly understood. Among them, bisphenol A (BPA) widespread in environment commonly ingested by because it used manufacture polycarbonate plastics, food-storage containers, other plastics. Thus, this study, we evaluated altered gene expression following exposure to BPA microarry...