A5017569198- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Chromatin Remodeling and Cancer
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Renal cell carcinoma treatment
- Multiple and Secondary Primary Cancers
- Cardiac, Anesthesia and Surgical Outcomes
- Endometriosis Research and Treatment
- Transplantation: Methods and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Economic and Financial Impacts of Cancer
- Healthcare professionals’ stress and burnout
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Uterine Myomas and Treatments
- Tumors and Oncological Cases
Memorial Sloan Kettering Cancer Center
2021-2024
Emory University
2016-2024
Harvard University
2017-2022
Brigham and Women's Hospital
2017-2022
Massachusetts General Hospital
2017-2021
University at Buffalo, State University of New York
2019
Emory University Hospital
2016
Williams College
2011
To characterize the somatic mutational landscape, investigate associations between genetic alterations and clinical outcomes, determine prevalence of pathogenic germline mutations in low-grade serous ovarian carcinomas (LGSC).
Abstract Purpose: Microsatellite instability–high (MSI-H) endometrial carcinomas are underpinned by distinct mechanisms of DNA mismatch repair deficiency (MMR-D). We sought to characterize the clinical and genetic features MSI-H cancers harboring germline or somatic mutations in MMR genes MLH1 promoter hypermethylation (MLH1ph). Experimental Design: Of > 1,100 patients with cancer that underwent tumor-normal sequencing, 184 had due MLH1ph, harbored pathogenic mutations....
Programmed death-1 (PD-1) inhibitors are approved for therapy of gynecologic cancers with DNA mismatch repair deficiency (dMMR), although predictors response remain elusive. We conducted a single-arm phase 2 study nivolumab in 35 patients dMMR uterine or ovarian cancers. Co-primary endpoints included objective rate (ORR) and progression-free survival at 24 weeks (PFS24). Secondary overall (OS), disease control (DCR), duration (DOR) safety. Exploratory biomarkers molecular correlates...
Although diabetes mellitus (DM) is a known risk factor for surgical complications in general, there little published evidence to establish such an effect among patients undergoing breast reconstruction (BR). The purpose of this study was assess the impact DM on postmastectomy BR.Patients who underwent BR at our institution from November 2002 2012 were identified. Clinical and demographic data with type 1 or 2 reviewed. Complications occurring within 60 days surgery compared between diabetic...
Abstract DNA-dependent protein kinase (DNA-PK) plays a crucial role in repair of DNA double-strand breaks by facilitating non-homologous end-joining. Inhibitors DNA-PK have the potential to block and enhance DNA-damaging agents. Peposertib (M3814) is inhibitor that has shown preclinical activity combination with agents, including ionizing radiation (IR) topoisomerase II inhibitors. Here we evaluated peposertib mouse xenograft model HPV-associated cervical cancer. Athymic nude female mice...
Abstract Background Data on platinum sensitivity of low‐grade serous ovarian carcinoma (LGSOC) in the upfront setting is lacking, and there limited contradictory information chemotherapy responses recurrent disease. Methods Patients with LGSOC seen at a comprehensive cancer center from January 1, 1998 to September 30, 2021 were identified institutional databases. Response neoadjuvant (NACT) or adjuvant platinum‐based second‐ fifth‐line regimens was retrospectively characterized by Evaluation...
We examined the safety and immunogenicity of sequential administration a tetravalent, non-HLA (human leukocyte antigen) restricted, heteroclitic Wilms’ Tumor 1 (WT1) peptide vaccine (galinpepimut-S) with anti–PD-1 (programmed cell death protein 1) nivolumab. This open-label, non-randomized phase I study enrolled patients WT1-expressing ovarian cancer in second or third remission from June 2016 to July 2017. Therapy included six (every two weeks) subcutaneous inoculations galinpepimut-S...
Background Although immune checkpoint blockade has demonstrated limited effectiveness against ovarian cancer, subset analyses from completed trials suggest possible superior efficacy in the clear cell carcinoma subtype. Objective To describe outcomes of patients with treated blockade. Methods This was a single-institution, retrospective case series programmed death protein 1 (PD-1) or death-ligand (PD-L1) inhibitor without concomitant cytotoxic T-lymphocyte-associated 4 (CTLA-4) inhibition...
We sought to determine the prevalence of germline pathogenic variants (gPVs) in unselected patients with endometrial cancer (EC), define biallelic gPVs within tumors, and describe their associations clinicopathologic features.
Abstract Background The Medicaid Analytic eXtract (MAX) is a health care utilization database from publicly insured individuals that has been used for studies of drug safety in pregnancy. Claims‐based algorithms defining many important maternal and neonatal outcomes have not validated. Objective To validate claims‐based identifying selected pregnancy MAX using hospital medical records. Methods records mothers who delivered between 2000 2010 within single large healthcare system were linked...
Bronchiolitis obliterans syndrome (BOS) is a severe manifestation of chronic graft-versus-host disease (cGVHD) following hematopoietic cell transplantation (HCT). Montelukast interrupts cysteinyl leukotriene (CysLT) activity and may diminish the activation homing cells to bronchioles subsequent fibrosis. We performed prospective phase II trial test whether montelukast altered lung decline for patients with BOS after HCT. In this single-arm, open-label, multi-institutional study, primary...
Objectives To investigate the association of molecular and pathologic factors with concurrent or recurrent ovarian disease to guide preservation in endometrioid endometrial cancer. Methods Patients cancer ≤50 years age at diagnosis were grouped by elective oophorectomy versus staging (January 2010 June 2021). Tumors stratified sub-type CTNNB1 mutational status next generation sequencing immunohistochemistry. Germline data identified patients Lynch syndrome. Associations between...
Abstract Background Racial disparities in outcomes exist endometrial cancer (EC). The contribution of ancestry‐based variations germline pathogenic variants (gPVs) is unknown. Methods Germline assessment ≥76 predisposition genes was performed patients with EC undergoing tumor‐normal Memorial Sloan Kettering Cancer Center Integrated Mutation Profiling Actionable Targets sequencing from January 1, 2015 through June 30, 2021. Self‐reported race/ethnicity and Ashkenazi Jewish ancestry data...
Perinatal epidemiology studies using healthcare utilization databases are often restricted to live births, largely due the lack of established algorithms identify non-live births. The study objective was develop and validate claims-based for ascertainment
Phenomenon: Obstetrics and gynecology can be a high-stress clinical environment for medical students due to the specialty's fast-paced unpredictable nature. Little is known about learning stressors on obstetrics clerkship inform stress-reducing interventions improve experience. This study investigated (a) which aspects of are most stressful students, (b) how perceived in this differ teachers (residents, fellows, faculty), (c) what propose address these stressors. Approach: From May 2015...