A5039452539- Digital Games and Media
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Educational Games and Gamification
- Social and Educational Sciences
- Innovative Human-Technology Interaction
- Interactive and Immersive Displays
- Education, Healthcare and Sociology Research
- RNA and protein synthesis mechanisms
- Modular Robots and Swarm Intelligence
- Data Visualization and Analytics
- Monoclonal and Polyclonal Antibodies Research
- Child Development and Digital Technology
- Microfluidic and Capillary Electrophoresis Applications
- Asymmetric Synthesis and Catalysis
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Educator Training and Historical Pedagogy
- Marine Sponges and Natural Products
- Cardiac electrophysiology and arrhythmias
- Robotic Path Planning Algorithms
- Pneumocystis jirovecii pneumonia detection and treatment
- Asymmetric Hydrogenation and Catalysis
- Tactile and Sensory Interactions
Novo Nordisk (Denmark)
2017-2025
Aarhus University
2000-2014
NeuroSearch (Denmark)
2013
The University of Queensland
2006-2011
Technical University of Denmark
2009-2010
University of Southern Denmark
2003-2008
Danish National Research Foundation
2005
Fully synthetic whole proteins in reach Solid-phase peptide synthesis of homogeneous peptides longer than about 50 amino acids has been a long-standing challenge because inefficient coupling and side reactions. Hartrampf et al. used an automated chemistry platform to optimize fast-flow were able produce fully single-domain (see the Perspective by Proulx). The targets included proinsulin enzymes such as barnase version HIV-1 protease containing multiple noncanonical acids. Refolded nearly...
To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its functionality, focusing on insulin secretion, proliferation, apoptosis ER stress, with objective to assess potential screening platform identification of novel anti-diabetic drug candidates.EndoC-βH1 was transplanted into mice validation in vivo functionality. Insulin secretion evaluated cultured monolayer pseudoislets, well diabetic mice. Cytokine induced apoptosis, glucolipotoxicity, stress responses...
Abstract Peptides play important roles in regulating biological processes and form the basis of a multiplicity therapeutic drugs. To date, only about 300 peptides human have confirmed bioactivity, although tens thousands been reported literature. The majority these are inactive degradation products endogenous proteins peptides, presenting needle-in-a-haystack problem identifying most promising candidate from large-scale peptidomics experiments to test for bioactivity. address this challenge,...
Peptide YY (PYY 3–36 ) has attracted attention in diabetes and obesity research because of its involvement food intake regulation glucose homeostasis. Native PYY maintains high potency on the Y 2 receptor with a loss 1 , 4 5 receptors. However, relatively short half-life, selectivity displayed by native peptide may not be optimal if long-acting analog is to developed. We performed variant screening identify key canonical amino acids that are pivotal selectivity, potency, stability. In...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDetermining a Synthetic Approach to Pierisformaside CSharon Chow, Christoph Kreß, Nanna Albæk, Carsten Jessen, and Craig M. Williams*View Author Information School of Chemistry Molecular Biosciences, University Queensland, Brisbane 4072, Australia[email protected]Cite this: Org. Lett. 2011, 13, 19, 5286–5289Publication Date (Web):September 12, 2011Publication History Received8 August 2011Published online12 September inissue 7 October...
<p>Ribosomes produce most proteins of living cells in seconds. Here we report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing peptide chains up to 164 amino acids over 328 consecutive reactions. The machine is rapid - chain elongation complete hours. We demonstrate utility this approach by chemical synthesis nine different protein that represent enzymes, structural units, and regulatory factors. After purification folding,...
DNA glue: A new alternate-strand linker (shown in green) has been synthesized that can connect two short sequences (5- and 9-mers, yellow) bind to double-stranded through major-groove interactions at pH 7.2 (see model). The resulting triple helices have high thermal stabilities as shown by melting temperatures exceeding 37 °C physiological values. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601127_s.pdf or from author....
Six new examples of intercalating nucleic acids were synthesized in order to evaluate the dependence length linker between oligo and intercalator on thermal stability their corresponding duplexes triplexes.
Being able to express oneself musically and experiment with music composition is traditionally determined by onepsilas ability play an actual instrument a certain degree of craftsmanship. The lack skills often makes it difficult make children young people experience the joy musical creativity, which essential element in education. This paper presents pilot project where modular robotics used create platform for creative expression that allows users genres without any prior knowledge or skills.
Abstract Phosphoramidites of several new twisted intercalating nucleic acid (TINA) monomers and the previously discovered ( R )‐1‐ O ‐[4‐(1‐pyrenylethynyl)phenylmethyl]glycerol 1 ) were synthesized used in DNA synthesis. Stabilization Hoogsteen‐type triplexes was observed cases insertion novel ‐[3‐(naphthalen‐1‐ylethynyl)phenylmethyl]glycerol 2 as a bulge into homopyrimidine oligodeoxynucleotides (ONs), whereas phenylethynyl 4‐(biphenylylethynyl) derivatives TINAs resulted destabilization...
Abstract Silver(I) acetylides facilitate direct carbon–carbon bond formation at the bridgehead position of adamantane, and in some instances related systems such as carborate anions bicyclo[2.2.2]octanes. Substrate constraints along with attempts to further understand underlying mechanism are presented. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Analogues of MKC-442 capable undergoing Michael addition reactions were synthesised in order to investigate the activity against HIV-1 mutant (Y181C). An improved was postulated on basis a possible covalent binding mercapto group Cys181. Lithiation C-6 position 1-ethoxymethyl-5-ethyl-1H-pyrimidine-2,4-dione (5) followed by reaction with alpha,beta-unsaturated aldehydes and oxidation alcohols formed give alkenoyl analogues 1a-3a. 1b-3b containing an allyloxymethyl N-1 instead ethoxymethyl...
Abstract This is the first report describing design, synthesis, and incorporation of an intercalating linker leading to efficiently 5′,5′‐linked alternate strand Hoogsteen triplex. Using molecular modeling, 5′,5′ problem was solved in a rather simple way. The two relatively distant 5′‐ends have been connected with molecule that provides rigidity structure, while being flexible enough allow stacking upon all four strands. synthesis core designed conducted by Sonogashira coupling appropriately...
Ribosomes produce most proteins of living cells in seconds. Here we report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing peptide chains up to 164 amino acids over 328 consecutive reactions. The machine is rapid - chain elongation complete hours. We demonstrate utility this approach by chemical synthesis nine different protein that represent enzymes, structural units, and regulatory factors. After purification folding, synthetic...
DNA-Kleber: Ein neuer Linker (grün) zwischen alternierenden Strängen wurde synthetisiert, der zwei kurze DNA-Sequenzen (Penta- und Nonamere, gelb) verknüpfen bei pH 7.2 über Wechselwirkungen durch die große Furche an doppelsträngige DNA binden kann (siehe Modell). Die resultierenden Tripelhelices sind thermisch sehr stabil, wie Schmelztemperaturen 37 °C physiologischen pH-Werten belegen.