A5037647145- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Polyoxometalates: Synthesis and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Differential Equations and Numerical Methods
- Chemical Synthesis and Reactions
- Numerical methods in engineering
- Synthetic Organic Chemistry Methods
- Advanced Nanomaterials in Catalysis
- Vanadium and Halogenation Chemistry
- Chemical synthesis and alkaloids
- Crystal structures of chemical compounds
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Supramolecular Self-Assembly in Materials
- Electromagnetic Scattering and Analysis
- Higher Education and Teaching Methods
- Natural Compound Pharmacology Studies
- Evaluation and Optimization Models
- Biological Activity of Diterpenoids and Biflavonoids
- Asymmetric Synthesis and Catalysis
- Traditional and Medicinal Uses of Annonaceae
Peking University
2020-2024
PLA Army Engineering University
2019-2024
Tsinghua University
2016-2023
Ningbo University
2023
Shanghai Jiao Tong University
2022
Jilin University
2012-2019
State Key Laboratory on Integrated Optoelectronics
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Institute of Electrical Engineering
2015-2017
Chinese Academy of Sciences
2015-2017
Capitalizing on the late-stage diversification of an essential 1,3-diene intermediate, we describe herein a 9-step enantioselective total synthesis (+)-hyperforin and (+)-pyrohyperforin, starting from commercially available allylacetone. Our convergent features series critical reactions: 1) deconjugative α-alkylation α,β-unsaturated acid using chiral lithium amides as noncovalent stereodirecting auxiliaries; 2) HfCl4 -mediated carbonyl α-tert-alkylation to forge intricate...
Capitalizing a synergy between late-stage C(sp3)–H alkynylation and series of transition metal-catalyzed alkyne functionalization reactions, we reported herein enantioselective divergent synthesis 10 diterpenoid pyrones within 14–16 steps starting from chiral pool enoxolone, including the first higginsianins A, B, D, E, metarhizin C. Our also highlights an unprecedented biomimetic oxidative rearrangement α-pyrone into 3(2H)-furanone, as well applications Echavarren reaction Toste...
We demonstrated a mode-locked erbium doped fiber laser (EDFL) operating at 1558 nm by exploiting ferroferric-oxide nanoparticles (FONPs) as the saturable absorber (SA) material. FONPs, with an average diameter of ~20 nm, were prepared thermal decomposition method, then mixed sodium carboxymethylcelluose to form FONP film. The SA was fabricated through sandwiched film between two connectors. By inserting FONPs into EDFL cavity pumped 980 diode, stable passive mode-locking achieved threshold...
Abstract Herein we report the first enantioselective total synthesis of 3,5‐dimethylorsellinic acid‐derived meroterpenoids (−)‐berkeleyone A and its five congeners ((−)‐preaustinoids A, A1, B, B1, B2) in 12–15 steps, starting from commercially available 2,4,6‐trihydroxybenzoic acid hydrate. Based upon recognition latent symmetry within D‐ring, our convergent features two critical reactions: 1) a symmetry‐breaking, diastereoselective dearomative alkylation to assemble entire carbon core, 2)...
Illihenin A (1), a novel sesquiterpenoid, was isolated from the roots of Illicium henryi. The structure determined by spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction. Compound 1 represents class 5/7/6 tricyclic sesquiterpenoids featuring rare cage-like tricyclo[6.2.2.01,5]dodecane core. plausible biosynthetic pathway rearrangement allo-cedrane is proposed. Additionally, showed potent antiviral activity against coxsackievirus B3 with an IC50 value 2.87 μM.
With diverse multi-dentate N-heterocyclic/diamine molecules as the cations, reactions between Cd2+ and SCN− in C2H5OH/H2O solution acidified by H2SO4 created five new thiocyanatocadmates [H2(bim)][Cd(SCN)2(H2O)2]SO4 (bim = 2,2′-biimidazole) 1, [H2(pympip)]2[Cd2(SCN)4(SO4)2(H2O)4]·2H2O (pympip 1-(2-pyrimidyl)piperazine) 2, [H2(tdpy)]2[Cd3(SCN)10] (tdpy 4,4′-thiodipyridine) 3, [H2(badpm)][Cd(SCN)4] (badpm 4,4′-biaminodiphenylmethane) 4 [H2(pdma)][Cd2(SCN)4(SO4)] (pdma...
We confirm the previously revised stereochemistry of spiroviolene by X-ray crystallographically characterizing a hydrazone derivative 9-oxospiroviolane, which is synthesized hydroboration/oxidation followed oxidation resultant hydroxy group. An unexpected thermal boron migration occurred during hydroboration process that resulted in production mixture 1α-hydroxyspiroviolane, 9α- and 9β-hydroxyspiroviolane after oxidation. The assertion
In this paper, we investigate the spectral method on quadrilaterals. We introduce an orthogonal family of functions induced by Legendre polynomials, and establish some results corresponding approximation. These play important roles in for partial differential equations defined As examples applications, provide schemes two model problems prove their accuracy Jacobi weighted Sobolev space. Numerical coincide well with analysis. also convex polygons whose solutions possess accuracy. The...
In this work, we confirmed that the copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction is an effective method for organic-functionalization of polyoxometalates (POMs). Herein, first time, four novel 1,2,3-triazole functionalized polyoxovanadate (POV) organic-inorganic hybrids, (Bu4N)2[V6O13{(OCH2)3C5H6N3O}2]·1.5CH3CN 2, (Bu4N)2[V6O13{(OCH2)3C7H8N3O2}2]·2CH3CN 3, (Bu4N)2[V6O13{(OCH2)3C11H10N3}2] 4 and (Bu4N)2[V6O13{(OCH2)3C10H7N3Cl}2] 5 were prepared through CuAAC using azide...
Through employing the hydrothermal in situ acylation of N2H4 with aromatic dicarboxylic acids, four new acylhydrazidate-coordinated complexes, [Cd2(pth)4(phen)2(H2O)2]·H2O (pth = phthalhydrazidate; phen 1,10-phenanthroline) 1, [Cd3(dcpth)6(phen)2(H2O)2] (dcpth 4,5-dichlorophthalhydrazidate) 2, [Cd(pdh)2(H2O)2] (pdh pyridine-2,3-dicarboxylhydrazidate) 3 and [Pb(sdpth)(phen)] (sdpth 4,4′-sulfoyldiphthalhydrazidate) 4, were obtained. X-ray analysis revealed that (i) isomerization deprotonation...
In an acidic solution, the room-temperature reactions of CdX2 (X(-) = Cl(-), Br(-) or CH3COO(-)) and organic N-heterocyclic molecules with without SCN(-)/SeCN(-)/dca(-) (dca(-) dicyanamide) created five new hybrid Cd(ii) compounds [H2(4,4'-dtdpy)]2[CdBr4]SO4·2.5H2O (dtdpy dithiodipyridine) 1, [H(2,2'-dtdpy)]2[CdBr4] 2, [(Hbim)2CdCl2(SCN)2] (bim 2,2'-biimidazole) 3, [H2(pip)][Cd(SCN)4] (pip piperazine) 4 [CdL2] (L HNC(OH)N(-)CN) 5. X-ray single-crystal diffraction analysis revealed that: (i)...
Recently, the organic functionalization of polyoxometalates (POMs) has drawn increasing interest, and an easy effective route to achieve derivatives is great importance. Herein, first reported synthesis a tosyl ester derivative polyoxometalate (Bu
The room-temperature reactions between CdX2, NH4SCN and bidentate N-heterocyclic molecules in acidic C2H5OH/H2O solutions yielded five new thiocyanatocadmates, [H2bpp][CdCl2(SCN)2] (bpp = 1,3-bis(4-piperidyl)propane) 1, [H2bpe][CdBr2(SCN)2] (bpe 1,2-bis(4-pyridyl)ethane) 2, [H2(4,4′-dtdpy)][Cd2(SCN)6] (4,4′-dtdpy 4,4′-dithiodipyridine) 3, [H2(4,4′-dtdpy)][CdBr2(SCN)2] 4 [H(2,2′-dtdpy)][Cd(SCN)3] (2,2′-dtdpy 2,2′-dithiodipyridine) 5. It is noteworthy that (i) compound Cd2+ SCN− aggregate...
The fungal cyclohexadepsipeptides destruxins (DTXs), isaridins (ISDs), and isariins (ISRs) are nonribosomal peptides whose structures include a 19-membered ring composed of five amino acid residues one α- or β-hydroxy residue. These contain unusual nonproteinogenic acid-building blocks possess range antiviral, antibacterial, other activities. biosynthetic gene clusters for ISDs ISRs have not been identified, the biosynthesis (3S)-methyl-l-proline residue, which is found in DTXs, ISDs, many...
The room-temperature self-assemblies between CdX2, NH4SCN and organic N-heterocyclic/diamine molecules in acidic C2H5OH/H2O solutions produced six organically templated chained thiocyanato(halo)cadmates [H2bp][CdCl2(SCN)2] 1, [H2bp][Cd(SCN)4] 2, [H2bpp][Cd3Br(SCN)7] 3, [H2bpy][CdBr2(SCN)2] 4, [H2bpe][Cd(SCN)4] 5 [H2dach][CdCl4] 6 (bp = 4,4′-bipiperidine; bpp 1,3-bis(4-piperidyl)propane; bpy 4,4′-bipyridine; bpe 1,2-bis(4-pyridyl)ethane; dach 1,4-diaminocyclohexane). Although the are...
Under hydrothermal conditions, the simple reactions between metal salts, aromatic polycarboxylic acids (4,4′-diphthalic anhydride ketone, dphahk; 4,4′-sulfoyldiphthalic anhydride, sdpha; pyridine-2,3-dicarboxylic acid, pdca) and N2H4·H2O with or without presence of phenanthroline·H2O (phen) yielded four di(mono)acylhydrazidate-coordinated Cd2+/Zn2+ compounds as [Cd(DPHKH)(phen)]·1.75H2O 1, [Zn3(DPHKH)2(HDPHKH)2(phen)2]·8H2O 2, [Cd(SDPTH)(phen)(H2O)]·H2O 3 [Zn(PDH)2(H2O)2] 4 (DPHKH =...
Abstract Pimarane-type diterpenoids are widely distributed in all domains of life, but no structures or catalytic mechanisms pimarane-type diterpene synthases (DTSs) have been characterized. Here, we report that two class I DTSs, Sat1646 and Stt4548, each accept copalyl diphosphate (CPP) as the substrate to produce isopimara-8,15-diene ( 1 ). can also syn -CPP -isopimaradiene/pimaradiene analogues 2 – 7 ), among which possesses a previously unreported "6/6/7" ring skeleton. We solve crystal...
At ambient temperature, with various mono(di)protonated N-heterocyclic or diamine molecules as the cations, seven new halo(pseudohalo)cadmates [H2(bpee)][Cd(SCN)4] (bpee = 1,2-bis(4-pyridyl)ethene) 1, [H2(bpyp)][CdBr2(SCN)2] (bpyp 1,2-bis(4-pyridyl)propane) 2, [H2(mbcha)][Cd3Br2(SCN)6] (mbcha 4,4′-methylenebis(cyclohexylamine)) 3, [(Hdabco)2Cd3(SCN)8] (dabco 1,4-diazabicyclo[2,2,2]octane) 4, [H2(bp)][Cd(SeCN)4] (bp 4,4′-bipiperidine) 5 [H2(pdma)][Cd(SeCN)4]·2H2O (pdma...