A5100739621- Magnolia and Illicium research
- Single-cell and spatial transcriptomics
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- RNA regulation and disease
- Cell Image Analysis Techniques
- Plant-derived Lignans Synthesis and Bioactivity
- Advanced biosensing and bioanalysis techniques
- Synthesis and Catalytic Reactions
- melanin and skin pigmentation
- Hearing, Cochlea, Tinnitus, Genetics
- Autoimmune and Inflammatory Disorders
- Synthesis and Biological Activity
- Cancer-related molecular mechanisms research
- Gene Regulatory Network Analysis
- Synthesis of β-Lactam Compounds
- Photosynthetic Processes and Mechanisms
- Advanced Chemical Sensor Technologies
- Analytical chemistry methods development
- Neurological Disease Mechanisms and Treatments
- Acne and Rosacea Treatments and Effects
- Cancer-related Molecular Pathways
- Traditional and Medicinal Uses of Annonaceae
- Bacteriophages and microbial interactions
- RNA modifications and cancer
Shaanxi University of Science and Technology
2022-2025
Tsinghua University
2021-2025
Nanjing Agricultural University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
University of Pennsylvania
2023
Shanghai Academy of Agricultural Sciences
2023
Nanfang College Guangzhou
2022
Nanfang Hospital
2022
Dongguan People’s Hospital
2018-2021
c-Jun NH2-terminal kinases (JNKs) are essential during brain development, when they regulate morphogenic changes involving cell movement and migration. In the adult, JNK determines neuronal cytoarchitecture. To help uncover molecular effectors for JNKs in these events, we affinity purified JNK-interacting proteins from brain. This revealed that stathmin family microtubule-destabilizing SCG10, SCLIP, RB3, RB3′ interact tightly with JNK. Furthermore, SCG10 is also phosphorylated by vivo on...
Pyrococcus furiosusArgonaute (PfAgo) emerged as a novel endonuclease for the nucleic acid test recently. However, input of exogenous guide DNA (gDNA) to activate PfAgo has reduced its flexibility. In this work, an enzyme-assisted endogenous gDNA generation-mediated target detection strategy, termed EGG-PAD, was proposed. With aid EcoR Ι, double-strand cut, producing phosphate group at 5′ end, functioning detection. The applicability assay tested in ofAlicyclobacillus acidoterrestris,...
The accumulation of massive single-cell omics data provides growing resources for building biomolecular atlases all cells human organs or the whole body. true assembly a cell atlas should be cell-centric rather than file-centric. We developed unified informatics framework seamless and built Ensemble Cell Atlas (hECA) from scattered data. hECA v1.0 assembled 1,093,299 labeled 116 published datasets, covering 38 11 systems. invented three new methods applications based on assembly: "in data"...
Abstract Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer’s disease vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers crossings dendrites caused death in rat hippocampi cortices. It also led to increase N-terminal β -amyloid precursor protein (N-APP) receptor-6 (DR6) levels activation caspase-3 caspase-6. Further study showed DR6 was downregulated miR-195...
Abstract The objective of this study was to investigate alterations brain activity and functional connectivity in patients with tinnitus, exploring neural features the transition from acute chronic phantom perception. Twenty‐four 23 32 healthy controls were recruited. High‐density electroencephalography (EEG) used explore changes areas different groups. When compared subjects, tinnitus had a significant reduction superior frontal cortex across all frequency bands, whereas at beta 3 gamma...
Introduction Source-to-sink (S2S) analysis plays a crucial role in sedimentological studies, serving as an effective tool for reconstructing sediment-routing processes and guiding hydrocarbon exploration. Numerous studies on S2S systems have focused examining the correlations among subsystems by statistically analyzing characterizing parameters of system. However, few focus quantifying degree interaction (i.e., coupling degree) between multiple sub-S2S systems, leading to biased...
Abstract Deciphering spatial domains using spatially resolved transcriptomics (SRT) is of great value for the characterizing and understanding tissue architecture. However, inherent heterogeneity varying resolutions present challenges in joint analysis multi-modal SRT data. We introduce a geometric deep learning method, named stMMR, to effectively integrate gene expression, location histological information accurate identifying from stMMR uses graph convolutional networks (GCN)...
Illihenin A (1), a novel sesquiterpenoid, was isolated from the roots of Illicium henryi. The structure determined by spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction. Compound 1 represents class 5/7/6 tricyclic sesquiterpenoids featuring rare cage-like tricyclo[6.2.2.01,5]dodecane core. plausible biosynthetic pathway rearrangement allo-cedrane is proposed. Additionally, showed potent antiviral activity against coxsackievirus B3 with an IC50 value 2.87 μM.
Abstract A new silver(I) triflate‐promoted tandem reaction comprising the ring opening of aziridines and a Michael has been developed. Using secondary amines or primary as nucleophiles, this methodology allows for synthesis cis ‐1‐alkyl‐4‐aminotetrahydroisoquinolines ‐1,3‐disubstituted isoindolines in good yields with excellent diastereoselectivities, respectively. Besides, easy operation mild conditions are also notable features reaction. magnified image
Abstract In 2017, a survey of the molecular epidemiology human adenovirus (HAdV) infections in Southern China based on hexon and fiber genotype demonstrated that most prevalent genotypes HAdV were HAdV-3 (n = 62), HAdV-2 21), HAdV-7 16). addition, two patients co-infected with HAdV. Interestingly, novel C recombinant strain was isolated from one pneumonia this survey. Phylogenetic, recombination, proteotyping analysis showed pathogen originated recombination parental viruses harboring HAdV-1...
Abstract Background Microspore culture is one of the important biotechnological tools in plant breeding. The induction microspore embryogenesis a critical factor that affects yield microspore-derived embryo productions. Cold treatment has been reported to reprogram gametophytic pathway various species. However, exact mechanism(s) underlying effect cold pre-treatment floral buds on efficiency ME still not clear. Results In this study, effects stress totipotency rice cultivar Zhonghua 11 were...
Using support from rational computer-assisted design, a novel series of hybrids designed by fusing the metal-chelating agent CQ and antioxidant ebselen were synthesized evaluated as multitarget-directed ligands.
The photosynthetic characters and water use efficiency of the desert plants Haloxylon ammodendron Calligonum mongolicum, which grow in conditions extreme stress, were studied. mechanisms their acclimation to harsh potential capacity for sand stabilizing are revealed. stable carbon isotope ratios (d 13C or 13C/12C) leaves assimilating shoots growing at southern edge Badain Jaran Desert analyzed by mass spectrometry compared. diurnal course net photosynthesis rate (Pn), Pn/light Pn/CO2 curves,...
This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity areas of brain and functional connectivity. High-density electroencephalography (EEG) was used investigate central nervous changes 25 ISSNHL subjects 27 healthy controls. had significantly reduced left frontal lobe at alpha 2 frequency band compared Linear lagged connectivity coherence analysis showed between temporal gyrus...