A5082706983- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- Diabetes Management and Research
- Systemic Sclerosis and Related Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Mast cells and histamine
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Ocular Surface and Contact Lens
- Diabetes Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Inflammatory Myopathies and Dermatomyositis
- Monoclonal and Polyclonal Antibodies Research
- Medical Practices and Rehabilitation
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Connective Tissue Growth Factor Research
Medical University of Graz
2017-2024
Ludwig Boltzmann Institute for Lung Vascular Research
2020
Medical University of Vienna
2020
Continuous and flash glucose monitoring ( GM ) systems have been established in diabetes care. We compared the sensor performance of 3 commercially available systems. A total 12 patients with type 1 were included a single‐centre, open‐label study which bbott FreeStyle libre bbott), D excom G4 P latinum excom) M edtronic MiniMed 640G edtronic) over hours was during mimicked real‐life conditions (meals, exercise, hypo‐ hyperglycaemia). Sensor determined by fulfilment ISO 15197:2013 criteria,...
Complete loss of β-cell function in patients with type 1 diabetes mellitus (T1DM) may lead to an increased risk severe hypoglycemia.We aimed determine the impact C-peptide status on glucagon response and endogenous glucose production (EGP) during hypoglycemia T1DM.We conducted open, comparative trial.Ten positive (C-pos) 11 matched negative (C-neg) T1DM were enrolled.Plasma was normalized over night fast, after a steady-state (baseline) plateau all underwent hyperinsulinemic, stepwise...
Introduction/Objectives: The patient perspective is an essential outcome parameter in the quest for effective therapy primary Sjögren's Syndrome (PSS). EULAR Patient Reported Index (ESSPRI) recommended by to quantify patient's symptom burden and has been used several clinical trials. Surprisingly, perception of dryness quantified with ESSPRI does not correlate objective measures salivary or lacrimal flow. Thus, we evaluated a newly developed assessment tool-the Primary Quality Life...
Systemic sclerosis (SSc) is an intractable autoimmune disease characterized by vasculopathy and organ fibrosis. Autologous hematopoietic stem cell transplantation (AHSCT) should be considered for the treatment of selected patients with rapid progressive SSc at high risk failure. It, however, remains elusive whether immunosuppressive therapies such as rituximab (RTX) are still necessary after AHSCT, especially in those bad outcomes. In present report, a 43-year-old man diffuse cutaneous...
Abstract Context The effect of liraglutide in C-peptide–positive (C-pos) type 1 diabetes (T1D) patients during hypoglycemia remains unclear. Objective To investigate the a 12-week treatment on body glucose fluxes hypoglycemic clamp C-pos T1D and its impact alpha- beta-cell responses hypoglycemia. Design This was randomized, double-blind, crossover study. Each patient allocated to sequence liraglutide/placebo or placebo/liraglutide with daily injections for 12 weeks adjunct insulin treatment,...
Abstract Introduction Scleroderma renal crisis (SRC) is a rare but one of the most recognised complications systemic sclerosis (SSc). Corticosteroid (CS) use has been considered as major risk factor for SRC. Several studies reported efficacy rituximab (RTX) with an acceptable safety profile in SSc. However, data on long‐term effect high‐dose CS concomitant to RTX kidney function are lacking. Methods We retrospectively analysed SSc patients (n = 35) treated lower dosage and short‐interval at...
<h3>Background</h3> Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease often diagnosed years after appearance of the first symptoms. Therefore, little known about initial development disease. Anti-Ro antibodies can be found before symptoms appear. <h3>Objectives</h3> To identify individuals at risk for pSS and follow up over 10 to examine immunopathology during pSS. <h3>Methods</h3> This ongoing longitudinal study enrolled developing but have not met ACR-EULAR classification...
<h3>Background</h3> Lymphocytic infiltration of the salivary and lachrymal glands is a hallmark primary Sjögren's Syndrome (PSS). Chronic inflammation leads to progressive destruction resulting in dryness eyes mouth termed sicca. The course pace sicca development PSS elusive. <h3>Objectives</h3> To explore effect symptom duration on disease activity. <h3>Methods</h3> Data patients from registry Medical University Graz fulfilling 2016 ACR/EULAR classification criteria for were analysed. We...
Background: The patient perspective is an essential outcome parameter in the quest for effective therapy primary Sjögren’s Syndrome (PSS). EULAR Patient Reported Index (ESSPRI) recommended by to quantify patient’s symptom burden and has been used several clinical trials. Surprisingly, perception of dryness quantified with ESSPRI does not correlate objective measures salivary or lacrimal flow. Objectives: Thus, we evaluated a newly developed assessment tool-the Primary Quality Life...
Background Primary Sjögren’s Syndrome (pSS) is a chronic autoimmune disease. Symptoms range from sicca to systemic, potentially life-threatening organ damage. Little known about the onset of Anti-Ro antibodies are described develop years before first symptoms. In addition, degree relatives pSS patients have an 11- 19- fold increased risk developing themselves. Objectives To identify and follow-up individuals at for in order study symptoms immune pathology development pSS. Methods this...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
<h3>Background</h3> In recent years, rheumatology research focused on first-degree relatives of people with rheumatic diseases, mainly rheumatoid arthritis, since they have a higher risk developing the disease compared general population and offer potential source insight into preclinical phase disease. However, evidence Sjögren's syndrome is still lacking. <h3>Objectives</h3> To explore perspective SS inform Pre-Sjögren's Syndrome Targeted Immunology Evaluation (PreSStige) study, conducted...
Background: B-cells play a major role in the pathogenesis and perpetuation of immune response systemic lupus erythematosus (SLE). So far, B-cell subtypes have been studied well, but precise mechanisms alterations during disease activity remission, depending on different medication, are still unclear. Objectives: The aim our study was to investigate drug dependent repertoire SLE patients with low (SLEDAI – 2K ≤4). Methods: Peripheral blood samples from 39 suffering (mean±SD; age 43±13 years,...
Zusammenfassung Der systemische Lupus erythematodes (SLE) ist eine Autoimmunerkrankung, die durch chronisch-rezidivierende Verläufe und ein breites Spektrum an klinischen Erscheinungsbildern gekennzeichnet ist. Pathophysiologisch wird dem B‑Lymphozyten, aufgrund seiner überschießenden Reaktion mit gestörter Autoantikörperproduktion, tragende Rolle in der Auslösung Aufrechterhaltung Erkrankung zugeschrieben. Aufgrund unseres besseren Verständnisses über diese Krankheit einer präziseren...
Background The PSS-QoL (the Primary Sjögren’s Syndrome Quality of Life Questionnaire) is a disease-specific health-related quality life (HRQL) questionnaire in primary Sjögren (PSS). psychometric testing showed valid and reliable assessment, which allows comprehensive evaluation the patients’ perspective extent disease PSS. Objectives To define threshold an acceptable QoL state (AQLS) minimal detectable change (MDC) PSS-QoL. Methods Data patients from PSS registry Medical University Graz...