Insulin stimulation drives the formation of a complex between tyrosine-phosphorylated insulin receptor substrate 1 (IRS-1) and 1-phosphatidylinositol 3-kinase (PI 3-kinase; ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase, EC 2.7.1.137), heterodimer consisting regulatory 85-kDa (p85) catalytic 110-kDa (p110) subunits. This interaction takes place via phosphorylated YMXM motifs IRS-1 Src homology region 2 (SH2) domains p85. In this study, stable overexpression in Chinese hamster ovary...

Monoclonal antibodies raised against the 85-kDa subunit (p85) of bovine phosphatidylinositol (PI) 3-kinase were found to recognize uncomplexed p85 or in active PI 3-kinase. Immunoprecipitation studies Chinese hamster ovary cells, which overexpress human insulin receptor when treated with insulin, showed increased amounts and activity immunoprecipitable monoclonal anti-p85 antibody no increase tyrosine phosphorylation p85. Insulin also induced an association tyrosine-phosphorylated substrate...

The purpose of this study is to assess the diagnostic ability (sensitivity and specificity) CT in diagnosis inflammatory abdominal aortic aneurysm (IAAA) quantitatively evaluate its features.A retrospective survey 355 consecutive patients with iliac artery who underwent examination surgical repair yielded 18 operatively confirmed IAAA. sensitivity, specificity, accuracy were evaluated review. Eighteen IAAAs then analyzed terms distribution degree perianeurysmal fibrosis as well...

To evaluate Sylvian fissure development by assessing angles in fetuses with malformation of cortical (MCD).This was a retrospective study 22 MCD. Cases stored three-dimensional (3D) brain volume acquired at 18 + 0 to 30 6 weeks gestation an ultrasound-based research clinic between January 2010 and December 2017 were identified through database. Of the fetuses, seven had extracranial abnormality, such as cardiac, renal, gastrointestinal and/or digital anomalies, five minor abnormality...

✓ Polyarteritis nodosa (PAN) is a rare systemic necrotizing arteritis that involves small- and medium-sized arteries in various organs. Although aneurysm formation visceral typical finding PAN, intracranial aneurysms are much less common, only few cases of rupture associated with this disease have been documented. In paper, the authors report on ruptured PAN anterior cerebral artery; lesion was trapped resected. On histological examination, extensive fibrinoid necrosis an inflammatory...

Background Idiopathic restrictive cardiomyopathy (RCM) is not a single disease and rare. Methods Results The clinical features course of 12 pediatric patients with RCM seen between 1978 2005 were retrospectively analyzed. age at diagnosis ranged from 4 months to years (median years). 7 diagnosed because an abnormal electrocardiogram (ECG) years. Three infants less than 2 old presented cardiomegaly. Obliquely elevated ST-T segments the late peak T waves on 12-lead ECG present in 8 (67%). ST...

Primary cardiac sarcomas are extremely rare. Furthermore, the myxofibrosarcomas one of rarest forms sarcomas, and its prognosis is known to be quite poor.This a case 23-year-old man who presented with acute severe congestive heart failure caused by almost complete obstruction mitral valve due large left atrial tumor. The patient required endotracheal intubation before his arrival hospital, underwent an emergent surgical excision tumor had complex shape originated from orifice right upper...

The conversion of (+)-carvone by Pseudomonas ovalis, strain 6-1, was investigated. (+)-Carvone found to be reduced (-)-isodihydrocarvone, (-)-isodihydrocarveol, (-)-neoisodihydrocarveol, (-)-dihydrocarvone, (-)-neodihydrocarveol, and (+)-dihydrocarveol, which the former three were major products. From these results, it postulated that has different pathways for (-)-carvone, respectively; is converted via (-)-isodihydrocarvone (-)-isodihydrocarveol whereas (-)-carvone (+)-dihydrocarvone...

The major component of the mosquito oviposition attractant pheromone (5S, 6R)-(+)- and (5R, 6S)-(-)-erythro-6-acetoxy-5-hexadecanolide their threo-isomers, 6S)-(-)-6-acetoxy-5-hexadecanolide were synthesized from isopropylidene-D-glyceraldehyde isopropylidene-L-glyceraldehyde, respectively, in which nucleophilic addition Grignard reagent involved diastereoface-differentiating process as key step. bioassay four erythro- threo-isomers against (Culex pipiens molestus) was conducted....

Maw (1970) はカプリン酸を処理した野外水が多種類の蚊を誘引し産卵させることを発見した. 池庄司ら (1975) はカプリン酸処理水から Pseudomonas aeruginosa を分離し, in vitro で A. ageypti (ネッタイシマカ) に対する産卵誘引物質を産生させた.本報は培地から, その誘引物質をエーテル抽出し, 脂肪酸を鹸化, 塩析により除去後, 薄層およびガスクロマトグラフィーで単離し, 質量スペクトルで, 7, 11-dimethyloctadecane と同定した. さらに, 二つの方法でこれを合成し, 確認した.しかし, 生物検定の結果, のみを含むと思われる分画は水道水と比較して, 6.7倍の誘引性を示したが, 合成物質は2.9倍の誘引性しか示さなかった. この誘引性の差についてはさらに検討中である.細菌, 藍藻などの水生生物による monomethyl hydrocarbons の生産は一般的であり, 本実験でも, 多量の n-heptadecane, n-octadecane の他 7-methyloctadecane...

Objectives: This study aimed to compare median nerve stiffness measured by ultrasound real-time tissue elastography in patients with and without rheumatoid arthritis (RA non-RA groups, respectively). Methods: Altogether, 402 hands of 201 RA group 222 111 were included the study. Ultrasonography was performed evaluate circumference, cross‐sectional area (CSA) strain ratio as an elasticity at inlet level carpal tunnel proximal portion inlet. Using propensity score matching, difference between...

土壌中よりリナロール資化性細菌を分離し,菌学的検討の結果Pseudomonas pseudomallei近縁株であることを知った.本菌株によるリナロール転換物として,樟脳, 4-methyl-4-vinylbutyrolactoneを同定し, 4-meth-yl-trans-3-hexenoic acid, 2, 6-dimethyl-6-hydroxy-trans-2, 7-octadienoic acidと考えられる物質を得た.

Background/Aims. Diabetes might increase the risk of Alzheimer's disease (AD). For detecting dementia, it is typical to obtain informants' perceptions cognitive deficits, but such interviews are usually difficult in routine care. We aimed develop a model for predicting mild moderate AD using self-reported questionnaire and by evaluating vascular factors dementia elderly subjects with diabetes. Methods. recruited 286 diabetic 155 nondiabetic subjects. There were 25 patients 261 cognitively...

(-)-Isopulegol and (+)-neo-isopulegol were isolated by a partial esterification of isopulegol mixture, obtained the hydrolysis condensation product (+)-citronellal with acetic anhydride. From infrared spectra optical rotation, it has been shown that synthesized from mainly consists (-)-isopulegol in approximately equal amounts, but presence other isomers is negligible.

The microbial esterification of (±)-menthol with various fatty acids by Pseudomonas sp. NOF-5 strain was investigated. A water insoluble acid higher than caproic esterified (-)-menthol high enantioselectivity; especially, when lauric used as the acid, yield ester satisfactory. racemic terpene alcohols same microorganism further studied. (-)-Isopulegol and (-)-trans-carveol were from their racemates stereoselectivity. However, (±)-cis-carveol poor enantioselectivity, (±)-citronellol entirely...

A new synthetic method of cyclotene (3-methyl-2-cyclopenten-2-ol-1-one) (I) and its derivatives has been investigated. The reaction 2-cyclopenten-2-ol-1-one aniline in toluene gave the corresponding ketimine derivative (V) good yield. methylation afforded 5,5-dimethyl-2-cyclopenten-2-ol-1-one (II) as major products, 3,5-dimethyl-2-cyclopenten-2-ol-1-one (III) 3,5,5-trimethyl-2-cyclopenten-2-ol-1-one minor products. Similarly, was alkylated with methyl iodide ethyl to yield (II), (III),...

A novel synthetic pathway to trans-4-amino-1-hydroxy-2-methyl-2-butene (7), a useful intermediate of zeatin, is presented here. On selective monophthalimide formation, the trans-1, 4-dibromo-2-methyl-2-butene (10) prepared from isoprene (1) predominantly gives trans-1-bromo-2-methyl-4-phthalimido-2-butene (11). The compound (11) converted 7 via trans-1-acetoxy-2-methyl-4-phthalimido-2-butene (6). overall yield 1 33.6%. Base-catalyzed hydrolysis 11 also directly. Zeatin can be by condensation...