A5056989979- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Infant Health and Development
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Infant Nutrition and Health
- Tea Polyphenols and Effects
- Genomics and Phylogenetic Studies
- Pediatric health and respiratory diseases
- Horticultural and Viticultural Research
- Cancer Immunotherapy and Biomarkers
- Microbial Community Ecology and Physiology
- Urinary Tract Infections Management
- Clinical Nutrition and Gastroenterology
- Fermentation and Sensory Analysis
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
European Molecular Biology Laboratory
2024-2025
European Molecular Biology Laboratory
2024
University of Würzburg
2024
University of Hohenheim
2018-2023
Fecal microbiota transplantation (FMT) is a promising therapeutic approach for microbiota-associated pathologies, but our understanding of the post-FMT microbiome assembly process and its ecological clinical determinants incomplete. Here we perform comprehensive fecal metagenome analysis 14 FMT trials, involving five pathologies >250 individuals, determine origins strains in patients after FMT. Independently underlying condition, conspecific coexistence donor recipient uncommon strain...
Abstract Background The understanding of how microbiomes assemble, function, and evolve requires metagenomic tools that can resolve microbiota compositions at the strain level. However, identification tracking microbial strains in fecal metagenomes is challenging available variably classify subspecies lineages, which affects their applicability to infer persistence transfer. Results We introduce SameStr, a bioinformatic tool identifies shared by determining single-nucleotide variants (SNV)...
Importance The effects of probiotic interventions on colonization with resistant bacteria and early microbiome development in preterm infants remain to be clarified. Objective To examine the efficacy Bifidobacterium longum subsp infantis , animalis lactis (BB-12), Lactobacillus acidophilus (La-5) probiotics prevent multidrug-resistant organisms or highly epidemic (MDRO+) shape toward eubiotic state healthy full-term infants. Design, Setting, Participants multicenter, double-blinded,...
Gut microbiota disruptions after allogeneic hematopoietic cell transplantation (alloHCT) are associated with increased risk of acute graft-versus-host disease (aGVHD). We designed a randomized, double-blind placebo-controlled trial to test whether healthy-donor fecal (FMT) early alloHCT reduces the incidence severe aGVHD. Here, we report results from single-arm run-in phase which identified best 3 stool donors for randomized phase. The primary and key secondary endpoints were engraftment...
Abstract Wine is a globally produced, marketed and consumed alcoholic beverage, which valued for its aromatic qualitative complexity variation. These properties are partially attributable to the bacterial involvement in fermentation process. However, organizational principles dynamic changes of wine microbiota remain poorly understood, especially context red white variations environmental stress factors. Here, we determined relative absolute compositions from six distinct cultivars during...
Abstract Enterotypes describe human fecal microbiomes grouped by similarity into clusters of microbial community composition, often associated with disease, medications, diet, and lifestyle. Numbers determinants enterotypes have been derived diverse frameworks applied to cohorts that lack diversity or inter-cohort comparability. To overcome these limitations, we selected 16,772 metagenomes collected from 38 countries revisit the using state-of-the-art fuzzy clustering found robust regardless...
Summary Fecal Microbiota Transplantation (FMT) has been clinically validated as a treatment for recurrent Clostridioides difficile infection (rCDI) and associated with the compositional functional restoration of patient gut microbiota. To characterize underlying microbiota dynamics donor strain engraftment, persistence replacement during FMT, we combined new existing metagenomic sequence data developed bioinformatic SameStr program species-specific detection shared subspecies lineages,...
There is an ongoing controversy around the existence of a prenatal, fetal microbiome in humans, livestock, and other animals. The 'in utero microbial colonization' hypothesis challenges clinical paradigm 'sterile womb' but has been criticized for its reliance on DNA-based evidence to detect microbiomes failure conciliate routine experimental derivation germ-free animals from surgically resected embryos with thriving microbiome. In order avoid propagation misinformation scientific literature,...
Objectives: Efficacy of multistrain probiotic with Bifidobacterium (B.) longum subsp. infantis, animalis lactis (BB-12), and Lactobacillus acidophilus (La-5) to prevent colonisation multidrug-resistant organisms or highly epidemic bacteria (MDRO+) shape the microbiome preterm infants towards eubiosis. Design, Setting, Participants: Multicenter, randomized, double-blinded, placebo-controlled, adaptive phase 3 trial (the PRIMAL trial) including 643 a gestational age 28 32 weeks at 18 German...
Immune checkpoint blockade (ICB) has become a standard anti-cancer treatment, offering durable clinical benefits. However, the limited response rate of ICB necessitates biomarkers to predict and modulate efficacy therapy. The gut microbiome's influence on is particular interest due its modifiability through various interventions. microbiome for have been inconsistent across different studies. Here, we identify TANB77, an uncultured distinct bacterial clade, as most consistent...
ABSTRACT Fecal microbiota transplantation (FMT) is both a promising therapeutic approach to treat microbiota-associated pathologies and an experimental tool establish causal role of microbiome dysbiosis in human pathologies. Although clearly efficacious resolving recurrent Clostridioides difficile infection (rCDI), the value FMT other not yet established, our mechanistic ecological understanding how alters patients incomplete. Here, we assembled most comprehensive trial dataset date,...
ABSTRACT As many inflammatory and metabolic disorders have been associated with structural deficits of the human gut microbiota, principles mechanisms that govern its initialization development are considerable scientific interest clinical relevance. However, our current understanding developing microbiota dynamics remains incomplete. We carried out a large-scale, comprehensive meta-analysis over 1900 available metagenomic shotgun samples from neonates, infants, adolescents, their families,...