A5047758731- Mesenchymal stem cell research
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Vector-Borne Animal Diseases
- Muscle Physiology and Disorders
- Vector-borne infectious diseases
- Parasitic infections in humans and animals
- Tissue Engineering and Regenerative Medicine
- Immune Response and Inflammation
- Bone fractures and treatments
- Toxoplasma gondii Research Studies
- Helminth infection and control
- Congenital Anomalies and Fetal Surgery
- Infant Nutrition and Health
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Eicosanoids and Hypertension Pharmacology
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Coccidia and coccidiosis research
- Entomopathogenic Microorganisms in Pest Control
- Studies on Chitinases and Chitosanases
Universidad de la República
2007-2024
Universidad de Montevideo
2022
Universidade Federal do Rio Grande do Sul
2016
Interactions hotes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides
2014
Automation and Process Engineering Laboratory
2014
École d'Ingénieurs en Chimie et Sciences du Numérique
2014
Biologie et Génétique des Interactions Plante-Parasite
2014
Centro Uruguayo de Imagenología Molecular
2012
Ohio University
2005-2010
Western University of Health Sciences
2010
Abstract Fasciola hepatica is the agent of fasciolosis, a foodborne zoonosis that affects livestock production and human health. Although flukicidal drugs are available, re-infection expanding resistance to triclabendazole demand new control strategies. Understanding molecular mechanisms underlying complex interaction with mammalian host could provide relevant clues, aiding search for novel targets in diagnosis fasciolosis. Parasite survival mediated by parasite compounds released during...
Since dogs play a central role in the contamination of humans and livestock with Echinococcus granulosus, development an effective vaccine for is essential to control disease caused by this parasite. For purpose, formulation based on biodegradable polymeric nanoparticles (NPs) as delivery system recombinant granulosus antigen (tropomyosin EgTrp) adjuved monophosphoryl lipid A (MPLA) has been developed. The obtained had size approximately 200 nm diameter into which was correctly preserved...
The expression of certain endothelial cell adhesion molecules (ECAMs) is increased in the vasculature inflamed bowel (e.g., colitis), thereby providing an opportunity for targeted drug delivery. We recently demonstrated that biodegradable particles conjugated with ligands to ECAMs exhibit significant selective ECAM expressing endothelium. In present study, we used a murine model colitis determine whether poly(lactic acid)-poly(ethylene glycol) VCAM-1 ligand (alpha-V) enhanced colitic...
Objectives The aim of this study was to isolate feline dental pulp stem cells (fDPSCs) and characterize their clonogenic proliferative abilities, as well multipotency, immunophenotype cytogenetic stability. Methods Dental isolated by explant culture from two cats <1 year old at post mortem. Their clonogenicity characterized using a colony-forming unit fibroblast assay, ability quantified with doubling time assay in passages 2, 4 6 (P 2 , P respectively). Multipotency an vitro trilineage...
One form of sepsis, or endotoxic shock, is a hyperactivated systemic response caused by excessive expression proinflammatory mediators, which results from Gram-negative bacterial lipopolysaccharide-stimulated Toll-like receptor-4 signaling. This lipopolysaccharide signaling known to consist MyD88-dependent nuclear factor-κB-mediated pathway that in production mediators (tumor necrosis factor-α, interleukin-6, intercellular adhesion molecule-1, vascular cell inducible nitric oxide synthase,...
ABSTRACT: Adipose tissue can be a source of bovine mesenchymal stromal/stem cells (MSCs). However, most studies do not incorporate post-mortem collection or in vitro differentiation these from fat and other sources into three mesodermal lineages. This study characterized cryopreserved adipose tissue-derived MSCs (AD-MSCs) collected post-mortem. Cells were isolated cattle (Bos taurus) cultured under standard conditions for ex vivo expansion cryopreservation. Cell growth kinetics was...
Stem cell therapy in cat patients needs a high quantity of mesenchymal stromal/stem cells (MSCs) requiring vitro propagation under culture conditions which may potentially impact cellular characteristics and genetic stability. This study aimed to assess the cytogenetic stability adipose tissue-derived MSCs (cAT-MSCs). For this purpose, morphological features, clonogenic potential, proliferative capacity cAT-MSCs were assessed at passages 2 (P
Canine chronic ulcerative stomatitis (CCUS) is a condition characterized by pain, associated with oral ulceration, inflammation and mucosal necrosis. We report the case of 5-year-old female Akita Inu canine sialorrhea, halitosis, ulcers, submandibular lymphadenopathy substantial discomfort. After poor response to conventional scaling antibiotic treatment, patient improved when prednisolone was administered at dose 1mg / kg daily. Aggressive immunosuppressive treatments teeth extractions were...