A5075507883- Gut microbiota and health
- Tumors and Oncological Cases
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Genetic Syndromes and Imprinting
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Teratomas and Epidermoid Cysts
- GDF15 and Related Biomarkers
- Cancer Diagnosis and Treatment
- Probiotics and Fermented Foods
- Metabolism, Diabetes, and Cancer
- Drug-Induced Adverse Reactions
- Organ Transplantation Techniques and Outcomes
- Veterinary Medicine and Surgery
- Epigenetics and DNA Methylation
- Vascular Malformations and Hemangiomas
- Veterinary Oncology Research
- Genomics and Phylogenetic Studies
- Hedgehog Signaling Pathway Studies
- Neuroblastoma Research and Treatments
- Mycobacterium research and diagnosis
- Liver Disease and Transplantation
Auburn University
2021-2024
Tufts University
2024
University of Wisconsin–Madison
2023
Overweight and obesity are growing health problems in domestic cats, increasing the risks of insulin resistance, lipid dyscrasias, neoplasia, cardiovascular disease, decreasing longevity. The signature feline gut microbiota has not been studied at whole-genome metagenomic level. We performed shotgun sequencing fecal samples eight overweight/obese normal cats housed same research environment. obtained 271 Gbp sequences generated a 961-Mbp de novo reference contig assembly, with 1.14 million...
Feline obesity is common, afflicting ~25-40% of domestic cats. Obese cats are predisposed to many metabolic dyscrasias, such as insulin resistance, altered blood lipids, and feline hepatic lipidosis. Fibroblast Growth Factor-21 (FGF21) an endocrine hormone that mediates the fat-liver axis, in humans animals, FGF21 can ameliorate non-alcoholic fatty liver disease, obesity. Activation pathway may have therapeutic benefits for obese cats.In this preliminary cross-sectional study, ad libitum...
Abstract Background Fecal specimens are critical for disease screening, diagnosis, and gut microbiome research. For domestic cats, lubricants often necessary to obtain a sufficient quantity of sample. However, the effect lubrication on feline analysis has not been assessed. Objectives To evaluate if using mineral oil during cat feces sample collection affects DNA extraction, metagenomic sequencing yield, microbial composition diversity in subsequent analyses. Animals Eight 6‐year‐old male,...
Introduction Microbial population structures within fecal samples are vital for disease screening, diagnosis, and gut microbiome research. The two primary methods collecting feline are: (1) using a loop, which retrieves rectal sample small, looped instrument, (2) the litter box, collects stool directly from litter. Each method has its own advantages disadvantages is suitable different research objectives. Methods results Whole-genome shotgun metagenomic sequencing were performed on...
A 1-year-old Miniature Horse filly was presented for chronic lethargy and hyporexia. Elevated liver enzymes, bile acids, ammonia were noted on bloodwork. The primary differential diagnosis a portosystemic shunt (PSS). Three-phase computed tomographic angiography findings consistent with transhepatic shunt. Percutaneous biopsy confirmed severe diffuse hepatic changes, most likely due to pyrrolizidine alkaloid toxicosis, medical management elected. Based an extensive literature review, this is...
In collaboration with the American College of Veterinary Pathologists.
A 25-y-old Percheron mare was admitted to the teaching hospital because of lethargy and intractable dyspnea. Thoracoabdominal ultrasound examination identified severe peritoneal effusion, mild bilateral pleural a diffuse pulmonary nodular pattern. Cytology fluid revealed hypercellular sample with clusters neoplastic polygonal cells admixed macrophages. Euthanasia followed by postmortem examination; marked bi-cavitary effusion present, innumerable up 4-cm diameter, round-to-floriform nodules...
Phosphoprotein enriched in astrocytes 15kDa (PEA15) is a ubiquitously expressed cytosolic protein with high expression the brain, and enhanced hypothalamus. Humans type 2 diabetes mellitus have increased of PEA15 adipose tissue skeletal muscle, overexpression transgenic mice pigs results peripheral insulin resistance. Despite these findings, studies fat diet (HF)-mediated obesity are limited. Male female Pea15-/- (KO) littermate controls (WT) were fed control (CD) or HF for 20 weeks, GTT at...
Hydroxycarboxylic acid receptor 2 (HCA2) , formally known as GPR109A, is a metabolite-sensing expressed predominately on adipocytes, immune cells and intestinal epithelial cells. The primary endogenous ligand of HCA2 β-hydroxybutyrate (βOHB) which elevated during periods nutrient deprivation including fasting. Previous in vitro studies have suggested that βOHB activation adipocytes inhibits lipolysis serves negative feedback mechanism to prevent excess fat loss However, the metabolic...