A5032603808- Veterinary Oncology Research
- Advanced Radiotherapy Techniques
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Breast Lesions and Carcinomas
- Radiation Dose and Imaging
- Hedgehog Signaling Pathway Studies
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Therapy and Dosimetry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peripheral Artery Disease Management
- Cervical Cancer and HPV Research
- Insect Utilization and Effects
- Histiocytic Disorders and Treatments
- Orthodontics and Dentofacial Orthopedics
- Management of metastatic bone disease
- Lung Cancer Research Studies
- Infectious Diseases and Mycology
- Obsessive-Compulsive Spectrum Disorders
- Venous Thromboembolism Diagnosis and Management
Auburn University
2016-2024
University of Georgia
2024
Jacksonville College
2010-2020
Mayo Clinic in Florida
2010-2020
WinnMed
2012-2020
D'Youville College
2019
The Christie NHS Foundation Trust
2018
Guildford Hospital
2016
University of Florida
2016
Mayo Clinic
2013-2015
Growing evidence from dogs and humans supports the abundance of mutation-based biomarkers in tumors dogs. Increasing use clinical genomic diagnostic testing now provides another powerful data source for biomarker discovery.Analyzed outcomes with cancer profiled using SearchLight DNA, a gene panel dogs, to identify mutations prognostic value.A total 127 cases were analyzed DNA which outcome information was available.Clinical points collected by medical record review. Variables including...
OBJECTIVE To estimate survival time for dogs with small intestinal adenocarcinoma (SIACA) following tumor excision or without adjuvant chemotherapy and to identify factors associated time. DESIGN Retrospective case series a nested cohort study. ANIMALS 29 client-owned surgically resected, histologically diagnosed SIACA. PROCEDURES Medical records were reviewed data collected regarding dog signalment; clinical signs; physical examination findings; PCV; serum total solids concentration;...
Despite significant advances in cancer diagnosis and treatment, osteosarcoma (OSA), an aggressive primary bone tumor, has eluded attempts at improving patient survival for many decades. The difficulty managing OSA lies its extreme genetic complexity, drug resistance, heterogeneity, making it improbable that a single-target treatment would be beneficial the majority of affected individuals. Precision medicine seeks to fill this gap by addressing intra- inter-tumoral heterogeneity improve...
Greater than 90% of dogs with appendicular osteosarcoma will develop pulmonary metastasis despite the standard care. Available treatments have limited efficacy for stage III disease. Zoledronate, a bisphosphonate, induces apoptosis canine cells and appears to modulate tumour microenvironment.This prospective, single institutional phase IIa trial investigated use agent zoledronate in metastases from osteosarcoma.Zoledronate was administered once monthly, thoracic radiographs were used assess...
To investigate the incidence of and potential risk factors for fat necrosis in high dose-rate (HDR) balloon-based breast brachytherapy (BBB).Fifty-four patients were treated postoperatively with HDR-BBB between May 2007 December 2010. Median age was 71 years (range: 50-88 years). tumor size 1 cm 0.1-2.7 cm). Forty-four had invasive histology; 43% grade 1, 24% 2, 15% 3. The median margin 0.7 0.1-1.5 cm).With a follow-up 2.9 0.5-5.2 years), local control 98% one in-breast failure, overall...
The purpose of this study was to introduce a planning strategy for dynamic conformal arc therapy (DCAT), named negative margin technique (NMT), and evaluate its dosimetric gain in lung stereotactic body radiation (SBRT). In DCAT, the field aperture is continuously conformed target volume (PTV) with an (AM) compensate penumbra effect gantry rotation. It common belief AM should be positive (or at least ‘zero'). However, radial width becomes significantly wider because overlapped beams...
Although canine multicentric lymphoma is initially responsive to multidrug chemotherapy, resistance and relapse create a need for novel chemotherapeutics. Bleomycin an antitumor antibiotic with minimal adverse event profile; though commonly used human non-Hodgkin's lymphoma, its use poorly characterized in dogs. The purpose of this retrospective case series was describe the clinical response profile systemic bleomycin (n = 10). A partial noted one dog that died 24 days later due unrelated...
Dynamic conformal arc therapy (DCAT) and flattening-filter-free (FFF) beams are commonly adopted for efficient dose delivery in stereotactic body radiation (SBRT).Off-axis geometry (OAG) may be necessary to obtain full gantry rotation without collision, which has been shown beneficial peripheral targets using flattened beams.In this study distributions OAG FFF were evaluated the effect of mechanical induced uncertainty was investigated.For lateral target, evaluation, sphere (2, 4, 6 cm...
In collaboration with the American College of Veterinary Pathologists.
To systematically analyze penumbra characteristics in co-planar arc-beams and demonstrate how optimal aperture margin (OAM) can be estimated.Full arc-beam delivery was simulated with a Pinnacle RTP for total of 32 cases. Considered factors were energy (6X, 6F, 10X, 10F, where 'F' indicates flattening-filter-free), field-size (2×2, 4×4, 6×6, 8×8), two materials (50×50×50 cm×cm×cm water 50×50×50 cmxcmxcm 20 cm diameter sphere 0.25 g/cc lung density at the center). The highest-dose-gradient...
Female mosquitoes utilize volatile organic compounds (VOCs) elicited from the host in order to determine preference. These VOCs include metabolites produced directly by or altered skin microflora and products of bacterial quorum sensing. This research examined what density is required for sensing elicit enough that can be utilized selection mosquitoes. The treehole mosquito, Aedes aegypti was used a series blood meal assays where females were given choice feeding on an artificial membrane...