A5025111283- Air Quality and Health Impacts
- Cancer Risks and Factors
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Effects and risks of endocrine disrupting chemicals
- Global Cancer Incidence and Screening
- Toxic Organic Pollutants Impact
- Heavy metals in environment
- Carcinogens and Genotoxicity Assessment
- Esophageal Cancer Research and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Climate Change and Health Impacts
- Environmental Justice and Health Disparities
- Childhood Cancer Survivors' Quality of Life
- Colorectal Cancer Treatments and Studies
- Birth, Development, and Health
- Body Composition Measurement Techniques
- Cutaneous Melanoma Detection and Management
- Helicobacter pylori-related gastroenterology studies
- Telomeres, Telomerase, and Senescence
GlaxoSmithKline (United States)
2024-2025
National Institute of Environmental Health Sciences
2016-2024
Reata Pharmaceuticals (United States)
2022-2024
National Health Research Institutes
2022
National Institutes of Health
2022
Federal Reserve
2021
Data Management (Italy)
2021
University of North Carolina at Chapel Hill
2016-2020
Public Health Department
2016-2020
Triangle
2020
Toxic metals show evidence of carcinogenic and estrogenic properties. However, little is known about the relationship between airborne breast cancer. We evaluated risk cancer in relation to exposure toxic metallic substances air, individually combined, a US-wide cohort.Sister Study participants (n = 50,884), cancer-free women who had sister with were recruited, from 2003 2009. The 2005 Environmental Protection Agency National Air Assessment's census-tract estimates metal concentrations air...
Epigenetic clocks use DNA methylation to estimate biological age. Whether body composition and physical activity are associated with these is not well understood. Using blood samples collected at enrollment (2003-2009) from 2,758 women in the US nationwide Sister Study, we calculated 6 epigenetic age acceleration metrics using 4 (Hannum, Horvath, PhenoAge, GrimAge). Recreational was self-reported, adiposity measures were assessed by trained medical examiners (body mass index (BMI),...
Exposure to wildfire smoke continues be a growing threat public health, yet the chemical components in that primarily drive toxicity and associated disease are largely unknown. This study utilized suite of computational approaches identify groups chemicals induced by variable biomass burn conditions were with biological responses mouse lung, including pulmonary immune response injury markers. Smoke condensate samples collected characterized, resulting distribution information for 86...
Anemia affects many patients with myelofibrosis and is associated poor prognosis. The Janus kinase inhibitor ruxolitinib often used in but may cause or worsen anemia. Using healthcare claims data from the IQVIA PharMetrics Plus database, this retrospective analysis evaluated resource utilization (HCRU), costs, treatment patterns ruxolitinib-treated stratified by anemia diagnosis prior to initiation. Of 11,499 diagnosed between January 2011 December 2022, 481 had ≥ 1 claim on after date were...
To date, epidemiologic studies have not strongly supported an association between pesticide exposure and breast cancer. However, few previous had the ability to assess specific time periods of exposure. Studies that relied on adult serum levels metabolites organochlorine pesticides may accurately reflect during developmental periods. Furthermore, assessment often occurred after diagnosis key tumor characteristics, such as hormone receptor status, rarely been available evaluate...
Potentially carcinogenic hazardous air pollutants (air toxics) have been inconsistently associated with breast cancer. Whether metabolic factors modify these associations is unknown. We studied 29 non-metallic toxics classified as mammary gland carcinogens in animal studies relation to cancer risk. Participants included 49,718 women from the Sister Study. Census tract toxic concentration estimates 2005 National Air Toxics Assessment were linked enrollment residential addresses. Adjusted...
The role of metals in breast cancer is interest because their carcinogenic and endocrine-disrupting capabilities. Evidence from epidemiologic studies remains elusive, prior have not investigated metal mixtures. In a case cohort nested within the Sister Study (enrolled 2003-2009; followed through September 2017), we measured concentrations 15 toenails collected at enrollment race/ethnicity-stratified sample 1,495 cases subcohort 1,605 women. We estimated hazard ratios 95% confidence intervals...
The 2010 Deepwater Horizon (DWH) oil spill response and cleanup (OSRC) workers were exposed to airborne total hydrocarbons (THC), benzene, toluene, ethylbenzene, o-, m-, p-xylenes n-hexane (BTEX-H) from crude PM2.5 burning/flaring natural gas. Little is known about asthma risk among workers.We assessed the relationship between several spill-related exposures including job classes, THC, individual BTEX-H chemicals, mixture, using data Gulf Long-Term Follow-up (GuLF) Study, a prospective...
During the past 40 years, esophageal/gastric cardia adenocarcinoma (EA/GCA) incidence increased in Westernized countries, but survival remained low. A parallel increase sugar intake, which may facilitate carcinogenesis by promoting hyperglycaemia, led us to examine sugar/carbohydrate intake association with EA/GCA and survival.
Night shift work has been classified by the International Agency for Research on Cancer as a probable carcinogen in humans. Several studies have assessed night relation to breast cancer risk, with inconsistent results.
Background Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous organic compounds associated with chronic disease in epidemiologic studies, though the contribution of PAH exposure on fatal outcomes U.S. is largely unknown. Objectives We investigated urinary hydroxylated metabolites (OH-PAHs) all-cause and cause-specific mortality a representative sample population. Methods Study participants were ≥20 years old from National Health Nutrition Examination Survey 2001–2014. Concentrations...
Recreational physical activity has been consistently associated with reduced breast cancer risk. Less is known about how family history of affects the association and whether it varies by menopausal status.The Sister Study a cohort 50,884 women who had sister but no prior themselves at enrollment. Women reported all recreational sport/exercise activities they participated in over past 12 months. Hours/week MET-hours/week were considered Hazard ratios (HR) 95% confidence intervals (CI)...
Abstract Background: An increased familial risk of breast cancer may be due to both shared genetics and environment. Women with a family history have higher prevalence cancer–related gene variants thus susceptibility environmental exposures. We evaluated whether air pollutant associations varied by risk. Methods: Sister Study participants living in the contiguous United States at enrollment (2003–2009; N = 48,453), all whom had least one first-degree relative cancer, were followed for...
Abstract Background Exposure to certain outdoor air pollutants may be associated with a higher risk of breast cancer, though potential underlying mechanisms are poorly understood. We examined whether pollution was involution terminal duct lobular units (TDLUs), the histologic site where most cancers arise and an intermediate marker cancer risk. Methods Pathologist-enumerated TDLUs were assessed in H&E (hematoxylin eosin)-stained tissue sections from 1904 US women ages 18–75 who donated...
Biologic pathways underlying the association between outdoor air pollution and breast cancer risk are poorly understood. Breast tissue composition may reflect cumulative exposure to factors has been associated with among patients benign disease. Herein, we evaluated whether fine particulate matter (PM
Background: Menopause timing is related to cancer, cardiovascular disease, and mortality. Lead has been associated with an earlier age at menopause, but no study considered exposure other metals or multiple simultaneously. Methods: At baseline, we measured toenail concentrations of 16 for 903 premenopausal women in the Sister Study (2003–2009). Age menopause was ascertained through follow-up questionnaires. Cox proportional hazard models were used estimate ratios (HRs) 95% confidence...