Jacob S. Witt

ORCID: 0000-0002-5891-8055
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About
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Research Areas
  • Advanced Radiotherapy Techniques
  • Lung Cancer Diagnosis and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Pancreatic and Hepatic Oncology Research
  • Breast Cancer Treatment Studies
  • Brain Metastases and Treatment
  • Lung Cancer Treatments and Mutations
  • Management of metastatic bone disease
  • Glioma Diagnosis and Treatment
  • Esophageal Cancer Research and Treatment
  • Lung Cancer Research Studies
  • Radiation Therapy and Dosimetry
  • Breast Lesions and Carcinomas
  • Medical Imaging Techniques and Applications
  • Neuroendocrine Tumor Research Advances
  • Cancer Genomics and Diagnostics
  • Hepatocellular Carcinoma Treatment and Prognosis
  • MRI in cancer diagnosis
  • Renal cell carcinoma treatment
  • Meningioma and schwannoma management
  • Cancer Immunotherapy and Biomarkers
  • Cancer Cells and Metastasis
  • Endometrial and Cervical Cancer Treatments
  • Advanced MRI Techniques and Applications
  • Radiopharmaceutical Chemistry and Applications

Cancer Care Specialists of Illinois
2021-2025

Illinois CancerCare
2025

University of Wisconsin–Madison
2018-2022

UW Health University Hospital
2018-2021

Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas
2019

University of Wisconsin Carbone Cancer Center
2019

Yonsei University
2018

Highland Community College - Illinois
2018

Medical College of Wisconsin
2015

Thomas Jefferson University
2015

To quantitatively predict the impact of cardiopulmonary dose on overall survival (OS) after radiotherapy for locally advanced non-small cell lung cancer.We used NRG Oncology/RTOG 0617 dataset. The model building procedure was preregistered a public website. Patients were split between training and set-aside validation subset (N = 306/131). 191 candidate variables covered disease, patient, treatment, dose-volume characteristics from multiple substructures (atria, lung, pericardium,...

10.1158/1078-0432.ccr-19-2627 article EN public-domain Clinical Cancer Research 2020-05-12

To examine the feasibility, tolerability, and toxicity of an intensified induction regimen (vincristine, ifosfamide, doxorubicin, etoposide [VIDE]) in patients with newly diagnosed Ewing's family tumors (EFT); to assess ability maintain dose-intensity, predictability peripheral-blood stem cell mobilization.Thirty were treated vincristine 1.4 mg/m2 (maximum 2 mg) on day 1, doxorubicin 20 mg/m2, ifosfamide 3 g/m2 plus mesna 150 days 1 3. Cycles given every 21 for up six cycles.One-hundred...

10.1200/jco.2003.04.106 article EN Journal of Clinical Oncology 2003-07-28

Regulating the transition from lineage-restricted progenitors to terminally differentiated cells is a central aspect of nervous system development. Here, we investigated role nucleoprotein geminin in regulating neurogenesis at mechanistic level during both Xenopus primary and mammalian neuronal differentiation vitro. The latter work utilized neural derived embryonic stem embryonal carcinoma vitro mouse forebrain. In all these contexts, antagonized ability basic helix-loop-helix (bHLH)...

10.1128/mcb.00737-12 article EN Molecular and Cellular Biology 2012-09-05

The purpose of this study was to evaluate predictors cardiac events in esophageal cancer patients treated with neoadjuvant chemoradiotherapy (NA CRT) followed by surgery compared alone.We retrospectively identified for between 2006 and 2016. A total 123 were identified; 70 alone, 53 NA CRT. Cardiac scored based on Common Terminology Criteria Adverse Events (version 4.03), dosimetric data compiled all who received radiation. Univariate analysis multivariable (MVA) performed identify events....

10.1097/coc.0000000000000573 article EN American Journal of Clinical Oncology 2019-07-17

Background Stereotactic body radiation therapy (SBRT) given in 1-5 fractions is an effective treatment for vertebral metastases. Real-time magnetic resonance-guided radiotherapy (MRgRT) improves soft tissue contrast, which translates into accurate delivery of spine SBRT. Here we report on clinical implementation MRgRT SBRT, the quality plans compared to TrueBeam based volumetric modulated arc (VMAT) metastases and benefits MR scan. Patients methods Ten metastatic lesions were included this...

10.2478/raon-2019-0042 article EN cc-by-nc-nd Radiology and Oncology 2019-09-01

This study reports dose corresponding to visible radiation induced liver damage following Stereotactic Body Radiation Therapy (SBRT) for metastasis, and the optimal time follow up scans using post imaging. Diagnostic magnetic resonance of nine patients treated with SBRT a 0.35 T MRI-guided radiotherapy system were analyzed. The dice coefficients between region delivered calculated. A median 35 Gy correlated most closely damage. We compared over two months observed maximal at five radiation....

10.1016/j.phro.2021.01.009 article EN cc-by-nc-nd Physics and Imaging in Radiation Oncology 2021-01-01

Our purpose was to determine the utilization of and barriers implementation radiopharmaceutical therapy (RPT) among U.S. radiation oncologists.An anonymous, voluntary 21-item survey directed toward attending oncologists distributed via social media platforms (Twitter, LinkedIn, Facebook, Student Doctor Network). Questions assessed practice characteristics, specific RPT prescribing patterns, interest, perceived implementation. Nonparametric χ2 test used for correlation statistics.Of 142...

10.1016/j.adro.2021.100827 article EN cc-by-nc-nd Advances in Radiation Oncology 2021-10-26

Prospective, randomized data regarding the use of postmastectomy radiotherapy (PMRT) in women who receive neoadjuvant chemotherapy (NAC) are lacking. The usefulness PMRT patients respond well to NAC forms basis ongoing National Surgical Adjuvant Breast and Bowel Project (NSABP) B51/Radiation Therapy Oncology Group (RTOG) 0413 clinical trial. Herein, authors review current literature examining role prior surgery.

10.1002/cncr.31785 article EN Cancer 2018-12-03

e11578 Background: While only 20% of all breast cancer is HER2+, it represents a disproportionate majority brain metastases, and up to half these patients will die CNS disease. Prophylactic cranial irradiation (PCI) reduces the risk metastases improves survival in small cell lung cancer, but at cost neurocognitive decline 30-40%. RTOG 0933 demonstrated reduction with hippocampal-avoidance (HA) whole radiation compared historic controls. HA-PCI may represent an approach reduce symptomatic...

10.1200/jco.2014.32.15_suppl.e11578 article EN Journal of Clinical Oncology 2014-05-20

652 Background: Radiation may have a role in management of patients with early-stage pancreatic cancer. However, the regional nodal irradiation (RNI) is not well defined despite high frequency occult disease. The goal this trial was to evaluate safety and feasibility stereotactic body radiation therapy (SBRT) primary disease RNI, combined capecitabine as neoadjuvant approach for resectable Updated survival analysis will be presented here. Methods: This prospective, single institution, phase...

10.1200/jco.2024.42.3_suppl.652 article EN Journal of Clinical Oncology 2024-01-20

(1) Urinary calcium excretion and creatinine clearance were measured in 8 patients before after hypophysectomy for advanced breast cancer. (2) Mean the group was lower than an earlier stage of metastatic (3) No consistent changes urinary could be correlated either with polyuria, spontaneous interphase, or vasopressin-induced reduction volume.

10.3181/00379727-109-27107 article EN Experimental Biology and Medicine 1962-01-01
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