A5059078250- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiovascular and Diving-Related Complications
- Atrial Fibrillation Management and Outcomes
- Infectious Aortic and Vascular Conditions
- Infective Endocarditis Diagnosis and Management
- Connective tissue disorders research
- Hip and Femur Fractures
- RNA modifications and cancer
- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Streptococcal Infections and Treatments
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cardiovascular Issues in Pregnancy
Union Hospital
2016-2025
Fujian Medical University
2016-2025
Education Department of Fujian Province
2022-2024
Creative Commons
2023
Yahoo (United Kingdom)
2023
Union Hospital
2022
Cleveland Clinic
2022
Faculty of 1000 (United States)
2022
RELX Group (United States)
2022
Abstract Acute type A aortic dissection (AAAD) has a high probability of postoperative adverse outcomes (PAO) after emergency surgery, so exploring the risk factors for PAO during hospitalization is key to reducing mortality and improving prognosis. An artificial intelligence approach was used build predictive model by clinical data‐driven machine learning predict incidence total arch repair AAAD. This study included 380 patients with The features that are associated were selected using...
Background Apolipoprotein C3 (apo C3) is primarily secreted by the liver and involved in promoting sterile inflammation organ damage under pathological conditions. Previous studies have shown that apo abundant plasma exosomes of patients with aortic dissection (AD), but its specific role AD remains unclear. Methods Results In vivo, adeno‐associated virus was used to knock down hepatic expression an mouse model assess impact liver‐derived on development AD. vitro, recombinant protein added...
The main strategy of tissue repair and regeneration focuses on the application mesenchymal stem cells cell-based nanoparticles, but there are still multiple challenges that may have negative impacts human safety therapeutic efficacy. Cell-free nanotechnology can effectively overcome these obstacles limitations. Mesenchymal cell (MSC)-derived natural small extracellular vesicles (sEVs) represent ideal nanotherapeutics due to their low immunogenicity lack tumorigenicity. Here, sEVs harvested...
Background The systemic inflammatory response index (SIRI) is a novel inflammatory-immune biological marker that has prognostic value in various cardiovascular diseases. This study aims to investigate the relationship between SIRI and short-term long-term prognosis patients with acute type A aortic dissection (AAAD) underwent surgical treatment. Methods We conducted retrospective analysis of AAAD who emergency treatment at our center. Through multifactorial logistics regression cox...
This study aimed to explore whether mechanical stretch aggravated aortic dissection through regulating MAPK pathway, MMP-9, and inflammation factors. We first established model rats. Mechanical (3 g) was exerted on vascular ring of which also treated by inhibitors pathway (SB203580, SP600125, U0126). HE Masson staining showed that severity with 3 g tension worse than without (0 g); after the treatments diverse inhibitors, fracture breakage elastic fibers decreased. The expression TNF-α,...
Hypertension is a key risk factor for spontaneous coronary artery dissection (SCAD) and aortic dilation. Circulating proteins play roles in range of biological processes represent major source druggable targets. The aim this study was to identify circulating that were associated with blood pressure (BP), SCAD We identified shared genetic variants BP genome-wide association studies, searched protein affected by these examined the levels BP, aneurysm (AAD) diameters integrating data from...
The aim of this study was to investigate the correlation between post-implantation syndrome (PIS) and long-term prognosis in patients with Stanford type B aortic dissection (TBAD) undergoing thoracic endovascular repair (TEVAR).
Abstract Studies have demonstrated a close correlation between MicroRNA and the occurrence of aortic dissection (AD). However, molecular mechanisms underlying this relationship not been fully elucidated further exploration is still required. In study, we found that miR‐485‐3p was significantly upregulated in human tissues. Meanwhile, constructed vitro AD models HAVSMCs, HAECs HAFs expression increased only HAVSMCs. Overexpression or knockdown HAVSMCs could regulate inflammatory cytokines...
Background:We aimed to analyze the risk factors and prognosis of acute kidney injury (AKI) after aortic arch repair in type A dissection. Material andMethods:We included 155 patients undergoing surgery for dissection from January 2009 2014 our hospital. Ninety-three underwent ascending replacement combined with open placement triple-branched stent graft 62 4-branched Dacron stented elephant trunk implantation into descending aorta. Univariate analysis multiple logistic regression were...
Abstract Background We studied early poor postoperative prognosis in acute Stanford type A aortic dissection (ATAAD) patients and investigated the predictive effect of interleukin-6 (IL-6) combined with D-dimer after ATAAD. Methods Data on 141 ATAAD patients, who underwent emergency surgery between January 2018 December at our hospital, were studied. analyzed using two patient groups. Patients good included group those B. Univariate logistic multivariable regression analysis performed for...
ObjectiveThis study aimed to investigate the predictive effect of preoperative and postoperative interleukin-6 (IL-6) levels on duration mechanical ventilation in patients with acute DeBakey Type I aortic dissection (I-AAD) after emergency surgery.MethodsWe retrospectively enrolled 381 I-AAD who underwent surgery our hospital, between June 2018 2022. Patients were divided into two groups according whether prolonged (PMV) occurred surgery. The baseline data, biochemical indicators at...
<b>Objectives</b> This study aims at assessing the safety and feasibility of intraoperative device closure perimembranous ventricular septal defect (VSD). <b>Methods</b> Total 89 patients in group I with 58 II surgical repair were enrolled our hospital to participate from January 2009 December 2010. In I, approach involved a minimal inferior median incision that was performed after full evaluation VSD by real-time transesophageal echocardiographic guidance, insertion an asymmetric or...
Insulin resistance (IR) plays a key role in the development of type 2 diabetes mellitus (T2DM) and is one its most important characteristics. Previous studies have shown that IR T2DM were independent risk factors for variety cardiovascular cerebrovascular diseases. However, there are few on relationship between aortic dissection (AD). The goal this research was to find evidence promotes occurrence AD.Through statistical analysis, we determined proportion glycosylated hemoglobin (HbA1c)...
Circulating proteins play functional roles in various biological processes and disease pathogenesis. The aim of this study was to highlight circulating associated with aortic aneurysm dissection (AAD) spontaneous coronary artery (SCAD). We examined the associations molecule levels SCAD by integrating data from a genome-wide association (GWAS) CanSCAD 7 pQTL studies. Mendelian randomization (MR) analysis applied examine between AAD using UK Biobank GWAS SCAD-associated SNPs 1q21.2 were...
This study aimed to assess the safety and feasibility of intraoperative device closure perimembranous ventricular septal defects (VSD) in young children guided by transthoracic echocardiography (TTE). We enrolled 18 patients from our hospital participate June 2011 September 2011. A minimal inferior median incision was performed after full evaluation VSD real-time TTE, a domestically made inserted occlude VSD. The proper size determined means echocardiographic analysis. Implantation...
Open repair of acute type A aortic dissection frequently results in oozing from the suture lines. modified fistula technique was developed to rapidly control and allow closing chest immediately safely. The efficiency this surgical evaluated.This a retrospective study. From January 2015 December 2016, 172 patients with underwent emergency our center. Among them, 76 were treated Cabrol (fistula group), others did not receive (nonfistula group). clinical data all retrospectively reviewed...
Abstract Background miR ‐ 145 is closely related to vascular smooth muscle cells (VSMC) phenotype transformation; however, the regulatory mechanisms through which regulates VSMC transformation under mechanical stretching are unclear. In this study, we evaluated roles of in VSMCs subjected aortic dissection (AD). Methods The expression miR‐145 vessel wall model animals and patients with AD was analyzed by quantitative polymerase chain reaction. miR‐145‐related protein‐protein interaction...