Free fatty acids (FFAs) exert divergent effects on β-cells. Acute exposure to FFAs stimulates insulin secretion, whereas chronic impairs β-cell function and induces apoptosis. The G protein-coupled receptor 40 (GPR40) is preferentially expressed in β-cells activated by a wide range of FFAs. In this study, we used small interfering RNA technology apoptosis assay mouse NIT-1 address the role GPR40 lipoapoptosis function. Results showed that palmitate induced apoptosis, which was not mediated...

Abstract Background To evaluate the impact of age on efficacy neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced rectal cancer (LARC). Method LARC undergoing NCRT and radical surgery from 2011 to 2018 were divided into young (< 40 years) old (≥40 groups. Multivariate analyses performed identify predictive factors for pathological complete response (pCR). Predictive nomograms decision curve analysis used compare models including/excluding Immunohistochemical was detect...

Abstract Background Transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) are effective treatment methods for unresectable hepatocellular carcinoma (HCC). However, there is still a lack of clinical research on whether early sequential RFA, compared with late combination therapy, can improve the long-term efficacy initial TACE treatment. Methods This retrospective study investigated cohort patients who underwent therapy using RFA (TACE followed by RFA) from January 2010 to...

Abstract Background Transarterial chemoembolization (TACE), radiofrequency ablation (RFA), and iodine 125 seeds implantation are optional treatments for hepatocellular carcinoma (HCC). The aim of this study is to compare the efficacy combined treatment TACE with (TACE-iodine 125) RFA (TACE-RFA) in patients early- intermediate-stage HCC. Methods included 112 who were diagnosed HCC from January 1, 2014, May 31, 2018. Among them, 38 treated TACE-Iodine 125, 74 TACE-RFA. two groups was...

Abstract Background Radiofrequency ablation (RFA) is an effective treatment for single hepatocellular carcinoma (HCC), but it difficult to use against tumors in some locations and often leads incomplete as a result of the heat‐sink effect. This study was conducted evaluate efficacy cryoablation compared with that RFA HCC. Methods retrospective based on Surveillance, Epidemiology, End Results (SEER) database. From 2004 2015, patients aged 40 79 diagnosed HCC were included study. A propensity...

This study aimed to assess the relationship between dyslipidemia (DL) risk and health-related physical fitness (HPF) evaluated prognostic value of HPF for DL.A total 776 university staff members were recruited, which 407 females, 369 males. Blood samples tests collected from all participants after 12 h fasting.The prevalence DL was 41.77% 51.49% in female male members, respectively, there no significant difference genders (χ2 = 2.687, p 0.101). According logistic regression analysis, age,...

The profile of differentially expressed microRNAs (miRNAs) in the serum patients with cardiac myxoma (CM) (n=30) and healthy people was studied using miRNA microarray analysis. expression candidate miRNAs validated by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) 30 CM control individuals. TargetScan, PicTar miRanda were used to predict possible target gene miR‑320a. Gene Ontology database Kyoto Encyclopedia Genes Genomes enrich functions signaling pathways genes,...

To evaluate the predictive value of preoperative biochemical marker [platelet-to-lymphocyte ratio (PLR)] in patients with advanced hepatocellular cancer receiving transarterial chemoembolization (TACE) plus targeted molecular therapy (apatinib) treatment. Clinical records 134 treatment TACE + apatinib (TACE-A) and alone were compared a single-center study. Time to progression (TTP) overall survival (OS) between TACE-A groups PLR > 150 ≤ 150, respectively. The area under receiver operating...

Hepatocellular carcinoma (HCC) includes cryptogenic hepatocellular carcinomas (CR-HCC) that lack a defined cause. Specific DNA methylation patterns and comparisons of the aberrant alterations in between CR-HCC adjacent peritumor tissues (APTs) have not yet been reported.The SureSelectXT Methyl-Seq Target Enrichment System was used to sequence targeted three paired APTs. Gene Ontology (GO) enrichment KEGG pathway analysis were performed investigate mechanism CR-HCC. The mRNA expression levels...

Background We developed an integrated triple-branched stent to treat acute DeBakey type I aortic dissection (AD) and modified it enhance its adaptability. However, whether the patients treated by would achieve better long-term prognosis is unknown. Methods This study enrolled 147 with AD. The original stents were used in 57 (Group A) between July 2012 August 2013, 90 B) September 2013 March 2015. Clinical characteristics, surgical data, postoperative complications, mortality, follow-up data...

Objective To determine if iodine-125 seed implantation improved the efficacy of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) (≤5 cm). Methods We retrospectively reviewed medical records 83 consecutive HCC cm) who underwent TACE or TACE–iodine-125 from January 2014 to July 2017. The primary endpoint was progression-free survival (PFS). secondary endpoints were overall (OS) and objective response rate (ORR) at 3 months after first treatment. PFS OS...

Sexual dysfunction after cardiac surgery can seriously affect patients' quality of life, but the impact on sexual function has long been neglected. Compared with conventional surgery, minimally invasive advantages aesthetic appearance and no disruption sternal structure, which greatly improve patient's life. However, studies focusing effects mitral valve (MIMVS) have not reported. The objective this research was to investigate totally endoscopic health-related life in male patients provide...

This study tends to assess the dose-dependent effects of spironolactone on TGF-β1 expression, atrial fibrosis, and vulnerability fibrillation in spontaneously hypertensive rats (SHRs) tries clarify association fibrosis with fibrillation.Forty 20-week-old male SHRs were randomly divided into 4 groups (10 per group): 3 lower-dose group mg·kg-1·d-1, dissolved 2 ml saline solution, SL), medium-dose (40 SM), higher-dose (80 SH) one hypertension (2 solution for stomach gavage, H). Ten matched...

To compare the effects of modified triple-branched stent implantation and frozen elephant trunk technique on quality life (QoL) acute Stanford Type A aortic dissection (AAAD) patients at different follow-up times. Data from 175 AAAD survivors was collected which were divided into two groups according to surgical techniques: (group A): graft implantation; B): trunk. The SF-36 used assess QoL discharge (AD), third postoperative month (POM3), twelfth (POM12). (1) total scores each time both...

To analyze the clinical outcomes of Transarterial chemoembolization (TACE) for unresectable or "ablation unsuitable" hepatocellular carcinoma (HCC) in caudate lobe (CL) found at initial presentation practice.Fifty-eight patients with HCC-CL undergoing conventional TACE from January 2015 to 2020 were enrolled our medical center. Overall survival (OS), progression-free (PFS), tumor response rate and major complication rates analyzed. Multivariate analyses potential radiologic factors performed...

Background: Osteoarthritis (OA) is a chronic joint disease characterized by the degradation of articular cartilage. Polyphyllin I (PPI) has anti-inflammatory effects in many diseases. However, mechanism PPI OA remains unclear. Methods: HC-a cells treated with IL-1β were identified immunofluorescence staining and microscopic observation. The expression collagen II DAPI was detected immunofluorescence. gradient concentration on IL-1β-induced cell viability, apoptosis, senescence, inflammatory...

The use of heart transplantation (HTx), a key life-saving therapy for end-stage failure, is limited by the shortage acceptable donor hearts. Although donation after circulatory death (DCD) offers potentially promising resource clinical transplantation, its adoption HTx concerned warm ischemic damage during process. Mesenchymal stem cell (MSC)-derived paracrine action has been proved to mediate cardioprotection. Based on our previous study showing that MSC conditioned media (MSC CM) and...

Resection of the hepatocellular carcinoma (HCC) in caudate lobe (CL) is challenging even for accomplished surgeons. This retrospective study evaluated safety and efficacy transarterial chemoembolization (TACE) iodine 125 seeds implantation (ISI) unresectable or "ablation unsuitable" HCC-CL detected at initial presentation clinical practice.A total 20 patients undergoing sequential TACE ISI from January 2014 to October 2018 were enrolled this study. The overall survival (OS), progression-free...

<h3>Purpose</h3> Pu-erh tea has recently become very popular in China and most southeast Asian countries. Fermented may help regulate blood lipids, prevent treat atherosclerosis (AS). Below, we discuss the effects of on AS. <h3>Methods</h3> Blood lipid levels, plaque size composition, pro-inflammatory cytokines expression NF-κB binding activity were determined ApoE null mice that consumed for either eight or 16 weeks. RAW264.7 cells treated with water extract vitro. <h3>Results</h3> In vivo,...