A5072236787- Chronic Kidney Disease and Diabetes
- Species Distribution and Climate Change
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Inflammatory mediators and NSAID effects
- Tissue Engineering and Regenerative Medicine
- Genetic diversity and population structure
- Renal and related cancers
- Eicosanoids and Hypertension Pharmacology
- Plant and animal studies
- Spider Taxonomy and Behavior Studies
- Cell Adhesion Molecules Research
- Lipoproteins and Cardiovascular Health
- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Insect and Arachnid Ecology and Behavior
- Hormonal Regulation and Hypertension
- Acute Kidney Injury Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Organ Transplantation Techniques and Outcomes
- Autophagy in Disease and Therapy
- Calpain Protease Function and Regulation
- Extracellular vesicles in disease
- Ecology and Vegetation Dynamics Studies
- Biomedical Ethics and Regulation
Aarhus University
2020-2025
Metropolitan University
2023
Abstract Climatic impacts are especially pronounced in the Arctic, which as a region is warming twice fast rest of globe. Here, we investigate how mean climatic conditions and rates change impact parasitoid insect communities 16 localities across Arctic. We focus on parasitoids widespread habitat, Dryas heathlands, describe community composition terms larval host use (i.e., herbivorous Lepidoptera vs. pollinating Diptera) functional groups differing their closeness associations (koinobionts...
Spiders at southern latitudes commonly produce multiple clutches, but this has not been observed high where activity seasons are much shorter. Yet the timing of snowmelt is advancing in Arctic, which may allow some species to an additional clutch. To determine if already happening, we used specimens wolf spider Pardosa glacialis caught by pitfall traps from long-term (1996–2014) monitoring programme Zackenberg, NE Greenland. We dissected individual egg sacs and counted number eggs partially...
Abstract Aim Renal fibrosis is a major driver of chronic kidney disease, yet current treatment strategies are ineffective in attenuating fibrogenesis. The cyclooxygenase/prostaglandin system plays key role renal injury and holds great promise as therapeutic target. Here, we used translational approach to evaluate the PGE 2 ‐EP 1 receptor pathogenesis several models injury, including human (fibrotic) slices. Methods anti‐fibrotic efficacy selective EP antagonist (SC‐19220) was studied mice...
Abstract Aim Biogeographical studies on the entire ranges of widely distributed species can change our perception species’ range dynamics. We studied effects Pleistocene glacial cycles current butterfly distributions, aiming to uncover complex biogeographic patterns in Holarctic, a region dramatically affected by Cenozoic climate change. Location Eurasia and North America. Taxon Boloria chariclea , Agriades optilete Carterocephalus palaemon Oeneis jutta . Methods reconstructed history four...
In brain death, cerebral injury contributes to systemic biological dysregulation, causing significant cellular stress in donor kidneys adversely impacting the quality of grafts. Here, we hypothesized that donation after death (DBD) undergo proteolytic processes may deem grafts susceptible posttransplant dysfunction. Using mass spectrometry and immunoblotting, mapped degradation profiles cytoskeletal proteins deceased living kidney biopsies. We found key DBD were proteolytically cleaved,...
Renal fibrosis, characterized by excessive extracellular matrix accumulation, leads to a progressive decline of renal function and is common endpoint chronic kidney disease (CKD). Current treatments primarily focus on managing underlying diseases, offering limited direct intervention for the fibrotic process. This study explores anti-fibrotic potential human adipose-derived mesenchymal stromal cells (MSCs) their derived vesicles (EVs) in context CKD, emphasizing effects systemic versus local...
Renal fibrosis is one of the main pathophysiological processes underlying progression chronic kidney disease and allograft failure. In past decades, overwhelming efforts have been undertaken to find druggable targets for treatment renal fibrosis, mainly using cell- animal models. However, latter often do not adequately reflect human pathogenesis, obtained results differ per strain within a given species, models are associated with considerable discomfort animals. Therefore, objective this...
ABSTRACT Spiders at southern latitudes commonly produce multiple clutches, but this has not been observed high where activity seasons are much shorter. Yet the timing of snowmelt is advancing in Arctic, and may allow some species to an additional clutch. To determine if already happening, we used specimens wolf spider Pardosa glacialis caught by pitfall traps from long-term (1996-2014) monitoring program Zackenberg, Northeast Greenland. We dissected individual egg sacs counted number eggs...
Renal fibrosis is a hallmark of Chronic Kidney Disease (CKD), which affects 10–16% the world’s adult population. It has previously been shown that cyclooxygenase/prostaglandin (COX/PG) system progression renal fibrosis. The downstream elements this system, eicosanoid prostaglandin (EP) receptors, EP 1–4 , have various physiological roles in health and disease. We therefore evaluated effect antagonizing one these receptors for prostaglandin, 1 receptor, on This was accomplished with...
Abstract BACKGROUND AND AIMS Accumulation of extracellular matrix (ECM) proteins is a hallmark renal fibrosis, leading to altered tissue homeostasis, kidney failure and ultimately death. Current treatment strategies are ineffective in halting fibrogenesis, drug discovery hampered by the lack clinically relevant biomarkers. Thus, there an urgent need for early pharmacodynamic biomarkers fibrosis support development new therapeutic treatments. In this study, we explored use non-invasive ECM...
ABSTRACT Background In brain death, cerebral injury contributes to systemic biological dysregulation, causing significant cellular stress in donor kidneys that adversely impacts the quality of grafts. Here, we hypothesized DBD may undergo proteolytic processes renders grafts susceptible post-transplant dysfunction. Material & Methods Using mass spectrometry and immunoblotting analyses, profiled degradation patterns cytoskeletal proteins deceased (n=55) living (n=10) kidneys. Results We...