A5022578136- Obstructive Sleep Apnea Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Gut microbiota and health
- Diet and metabolism studies
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Neuroscience of respiration and sleep
- Advanced MRI Techniques and Applications
- Voice and Speech Disorders
- Bone health and treatments
- Spinal Cord Injury Research
- Birth, Development, and Health
- Bone health and osteoporosis research
- Memory and Neural Mechanisms
- Cardiovascular Health and Disease Prevention
- Dysphagia Assessment and Management
- Cancer, Hypoxia, and Metabolism
- Liver Diseases and Immunity
- Spinal Hematomas and Complications
- Eosinophilic Esophagitis
- Digestive system and related health
- Cardiomyopathy and Myosin Studies
- Folate and B Vitamins Research
- Aortic Disease and Treatment Approaches
Semmelweis University
2021-2025
National Institute of Oncology
2021
Background and Objectives: There is an increasing focus on the effect of gut microbiome developing atherosclerosis, but there still no unified standpoint. We aimed to find associations between intestinal diversity a marker subclinical carotid intima-media thickness (IMT). Materials Methods: Recruited from Hungarian Twin Registry, 108 monozygotic (MZ) twins (mean age 52.4 ± 14.1 years, 58% female) underwent comprehensive ultrasound examination (Samsung RS85). Of MZ twins, 14 pairs 65 6.4 71%...
Background: Obstructive sleep apnoea (OSA) is a risk factor for cardiovascular disease. Alterations in the gut microbiome have been implicated development of disease and may potentially link OSA to its consequences. However, only one study date has investigated microbiomes adult patients with OSA. Methods: 19 20 non-OSA controls participated study. Following diagnostic study, blood was collected metabolic profiling, subjects provided stool sample analysis. The using 16S ribosomal RNA method....
Background and Objective: Brain morphometry is shaped by a complex interplay of genetic environmental factors, including physiological neuropsychiatric conditions. These influences can vary across distinct brain regions, yet the precise contributions genetics environment to regional variation in healthy brains remain poorly understood. This study examines heritability specific structures provide deeper insights into their development. Materials Methods: We studied 118 adult twins from...
Background and Objectives: Previous studies have demonstrated that risk of hip fracture is at least partly heritable. The aim this study was to determine the magnitude genetic component bone mineral density (BMD), using both X-ray ultrasound assessment multiple sites. Materials Methods: 216 adult, healthy Hungarian twins (124 monozygotic, MZ, 92 dizygotic, DZ; mean age 54.2 ± 14.3 years), recruited from Twin Registry with no history oncologic disease underwent cross-sectional BMD studies. We...
Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average 34 ± 22 years), including 1044 pairs, 24 triplets one quadruplet set. In HTR transformed from into population-based one, it was established in Medical Imaging Centre Semmelweis University Budapest. University's innovation fund supported development information technology, phone bank voicemail infrastructure,...
Objectives To investigate the prognostic value of clinical, volumetric, and radiomics-based textural parameters in baseline [ 18 F]FDG-PET/CT scans diffuse large B-cell lymphoma (DLBCL) patients. Methods We retrospectively investigated PET/CT collected clinical data fifty DLBCL PET images were segmented semiautomatically to determine metabolic tumor volume (MTV), then largest interest (VOI) was used extract first-, second-, high-order features. A novel value, MTVrate introduced as quotient...
Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, intestinal microbiome, all in animal models. Methods: Twenty-two patients with 16 6 without carotid atherosclerosis were involved study. After a diagnostic examination, intima media thickness (IMT) was measured plaques found using ultrasound. Blood also drawn metabolic profile, stool sample...
Background and Objectives: Subcortical grey matter structures play essential roles in cognitive, affective, social, motoric functions humans. Their volume changes with age, decreased volumes have been linked many neuropsychiatric disorders. The aim of our study was to examine the heritability six subcortical brain (the amygdala, caudate nucleus, pallidum, putamen, thalamus, nucleus accumbens) four general total intra-cranial matter, white cerebrospinal fluid (CSF) volume) twins. Materials...
Abstract Previous studies suggested cervical spondylosis as a risk factor for development of obstructive sleep apnoea (OSA). We aimed to assess lumbar disc degeneration in patients with OSA and correlate the findings symptoms disease severity. Twenty-seven 29 non-OSA controls underwent magnetic resonance imaging (MRI), completed Epworth Sleepiness Scale 24-item Roland‐Morris Disability Questionnaire (RMDQ) questionnaires. Plasma klotho was determined enzyme-linked immunosorbent assay....
Introduction: White matter hyperintensities (WMH) indicate white brain lesions in magnetic resonance imaging (MRI), which can be used as a marker for aging and cerebrovascular neurodegenerative disorders. Twin studies revealed substantial but not uniform WMH heritability elderly twins. The objective of our study was to investigate the genetic environmental components WMH, well their importance healthy twin population, utilizing 3T MRI scanners middle-aged population. Methods: Brain performed...
Background and Objectives: The asymmetrical vertebral artery (VA) flow diameter are common findings, which can result in an blood the basilar (BA), leading to bending of over time. This study investigated whether variation different vertebrobasilar morphological indices that influence characteristics might be inherited. Materials Methods: We analyzed 200 cerebral magnetic resonance imaging (MRI) scans healthy Caucasian twins (100 pairs) who underwent time-of-flight MRI. From scans, we...
Most previous research found that within-family resemblance on social outcomes and intelligence is mostly due to genetic factors with a limited role of the shared environment, exception educational attainment. Hypotheses about gene-environment interaction SES, presumably smaller in families low status, have been only partially confirmed. However, these results do not necessarily generalize all societies, data from Central or Eastern European countries currently deficient. In current work we...
Abstract There is abundant evidence that bone mineral content highly heritable, while the heritability of quality (i.e. trabecular score [TBS] and quantitative ultrasound index [QUI]) rarely investigated. We aimed to disentangle role genetic, shared unique environmental factors on TBS QUI among Hungarian twins. Our study includes 82 twin (48 monozygotic, 33 same-sex dizygotic) pairs from Twin Registry. was determined by DXA, calcaneal ultrasound. To estimate genetic effects, we utilized...
Abstract Objective We aimed to study the possible factors influencing visualisation of brown adipose tissue (BAT) on FDG PET/CT at diagnosis in children. Method A total 92 children or adolescents were included (63 patients with Hodgkin lymphoma (HL) and 29 sarcoma). examined images obtained searched for uptake BAT. analysed relationship between BAT activation different factors, such as age, sex, outside temperature season, histological type malignancy (HL sarcoma), volumetric metabolic...
Background and Objectives: Progressive supranuclear palsy (PSP) is a neurodegenerative disease, tauopathy, which results in wide clinical spectrum of neurological symptoms. The diagnosis mostly based on signs neuroimaging; however, possible biomarkers for screening have been under investigation, the role gut microbiome unknown. aim our study was to identify potential blood observe variations within PSP discordant monozygotic twin pair. Materials Methods: Anthropometric measurements,...
Background and objectives: Multivessel atherosclerosis its genetic background are under-investigated, although is seldom local still causes high mortality. Alternative methods to assess coronary calcification (CAC) might incorporate links between different arteries’ atherosclerotic involvement, however, co-occurrences of have not been investigated in twins yet. Materials Methods: We assessed the heritability radio morphologically distinct plaque types (non-enhanced CT, Agatston score),...
Abstract Previous studies suggested cervical spondylosis as a risk factor for development of obstructive sleep apnoea (OSA). We aimed to assess lumbar disc degeneration in patients with OSA and correlate the findings symptoms disease severity. Twenty-seven 29 non-OSA controls underwent magnetic resonance imaging (MRI), completed Epworth Sleepiness Scale 24-item Roland‐Morris Disability Questionnaire questionnaires. Plasma klotho was determined enzyme-linked immunosorbent assay.Patients had...
Introduction: Obstructive sleep apnea (OSA) is a common disorder characterized by the repetitive collapse of upper airways during sleep, most likely in oropharyngeal region. Anatomical factors significantly contribute to disease development; however, heritability airway dimensions, which lead collapsibility airways, less known. In current study, we aimed quantify impact heritable and environmental on dimensions twins using magnetic resonance imaging (MRI). Methods: We completed head neck MRI...
Background and Objectives: Aortic arch calcification (AoAC) is associated with a variety of cardiovascular complications. The measurement grading AoAC using posteroanterior (PA) chest X-rays are well established. cardiothoracic ratio (CTR) can be simultaneously measured PA used as an index cardiomegaly. genetic environmental contributions to the degree CTR not understood. purpose this study was investigate effect genetics factors on CTR. Materials Methods: A total 684 twins from South Korean...
Background: Recurrent upper airway obstruction during sleep is a common feature of obstructive apnea (OSA). Risk factors for the development OSA include obesity, male gender and smoking. In addition, anatomical contribute to disease; however, heritability structures that determine narrowing poorly understood. this study, we aimed investigate background associated with in discordant monozygotic (MZ) twin pairs. Methods: 33 adult MZ pairs (median age Q1-Q3: 50 (42–56) years) from Hungarian...
Most previous research found that within-family resemblance on social outcomes (such as educational and income) intelligence is mostly due to genetic factors with a limited role of the shared environment, exception attainment. Hypotheses about gene-environment interaction SES, presumably smaller in families low status, have been only partially confirmed. However, these results do not necessarily generalize all societies, data from Central or Eastern European countries currently deficient. In...
Objectives of the study Nonalcoholic fatty liver disease (NAFLD) is a common condition with subset individuals developing fibrosis as major risk factor for advanced disease. The contribution genetic factors to this progression remains incompletely understood. Our aim was analyze heritability in development estimated by ultrasound shear wave elastography (SWE) an asymptomatic adult twin cohort. Methods In total 172 Hungarian twins (51 monozygotic and 36 dizygotic pairs; 63% women; mean age...