A5027184212- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuropeptides and Animal Physiology
- Advanced Neuroimaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Hypothalamic control of reproductive hormones
- EEG and Brain-Computer Interfaces
- Neuroendocrine regulation and behavior
- Schizophrenia research and treatment
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Regulation of Appetite and Obesity
- Cerebrovascular and Carotid Artery Diseases
- Stalking, Cyberstalking, and Harassment
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Vascular Tumors and Angiosarcomas
- Ultrasound and Hyperthermia Applications
- Trigeminal Neuralgia and Treatments
- LGBTQ Health, Identity, and Policy
- Evolutionary Psychology and Human Behavior
- MRI in cancer diagnosis
Czech Academy of Sciences, Institute of Physiology
2024-2025
University of Pecs
2014-2025
Semmelweis University
2008-2022
Szent János Kórház
2008
Introduction: While amnestic mild cognitive impairment (aMCI) and non-amnestic (naMCI) are theoretically different entities, only a few investigations studied the structural brain differences between these subtypes of impairment. The aim study was to find aMCI naMCI, replicate previous findings on differentiation healthy controls. Methods: Altogether 62 aMCI, control subjects were included into based Petersen criteria. All patients underwent routine MR examination, detailed...
Gender identity disorder (GID) refers to transsexual individuals who feel that their assigned biological gender is incongruent with and this cannot be explained by any physical intersex condition. There growing scientific interest in the last decades studying neuroanatomy brain functions of better understand both neuroanatomical features transsexualism background identity. So far, results are inconclusive but general, has been associated a distinct pattern. Studies mainly focused on male...
Conspecific-preference in social perception is evident for multiple sensory modalities and many species. There also a dedicated neural network face processing primates. However, the evolutionary origin relative role of species sensitivity visuo-social are largely unknown. In this comparative study, to identical visual stimuli (videos human dog faces occiputs) were examined using functional magnetic resonance imaging dogs ( n = 20; 45% female) humans 30; 50% female). dogs, bilateral mid...
Background It is anticipated that current and future preventive therapies will likely be more effective in the early stages of dementia, when everyday functioning not affected. Accordingly identification people at risk particularly important. In most cases, subjects visit an expert are examined using neuropsychological tests, disease has already been developed. Contrary to this cognitive games played by healthy, well elderly people, who should monitored for signs. Further advantages their...
Abstract Background The tachykinin substance P (SP) facilitates learning and memory processes after its central administration. Activation of different receptive sites, neurokinin-1 receptors (NK1Rs), as well NK2Rs NK3Rs was shown to influence memory. basal ganglia have been confirmed play an important role in the control spatial mechanisms, part ganglia, globus pallidus (GP) may also be involved this regulation. SP-immunoreactive fibers terminals, NK1Rs NK3Rs, were present GP. Methods study...
Background and aim: Severe eating disorders, such as obesity, bulimia, anorexia, keep increasing to epidemic proportions worldwide. Understanding of neuropeptides’ role in complex hunger/satiety mechanisms may allow new prospects for treatment prevention. Pyroglutamylated arginine-phenylalanine-amide peptides (QRFPs) are thought enhance feeding following the central administration. Methods: In our study, QRFP-26 was delivered into lateral hypothalamic area male Wistar rats by direct...
Pazopanib is a tyrosine-kinase inhibitor also used for the treatment of advanced soft tissue sarcomas. Our retrospective study analyzed real-world data stage 4 sarcoma patients treated with pazopanib in our department past 10 years. Data were collected from Medworks medical system, which daily work center. A total 99 included: 46 men and 53 women The median age at diagnosis was 49.8 most common histological subtypes leiomyosarcoma synovial sarcoma. All received 800 mg per day, reduced to 400...
Abstract Background Schizophrenia (SZ) is a complex disorder characterized by range of behavioral and cognitive symptoms as well structural functional alterations in multiple cortical subcortical structures. SZ associated with reduced network connectivity involving core regions such the anterior cingulate cortex (ACC) thalamus. However, little known whether effective coupling, directed influence one structure over other, altered during rest ACC–thalamus network. Methods We collected...
Osteoprotegerin (OPG) is a marker and regulator of arterial calcification, it related to cardiovascular survival in haemodialysis patients. The link between OPG aortic stiffening--a consequence calcification--has not been previously evaluated this population, known whether OPG-related mortality risk mediated by stiffening.At baseline, pulse wave velocity (PWV) were measured 98 chronic patients who followed for median 24 months. relationship PWV was assessed multivariate linear regression....
Generally, the interpretation of functional MRI (fMRI) activation maps continues to rely on assessing their relationship anatomical structures, mostly in a qualitative and often subjective way. Recently, existence persistent stable brain networks nature has been revealed; particular these so-called intrinsic connectivity (ICNs) appear link patterns resting state task-related connectivity. These provide an opportunity functionally-derived description fMRI maps, that may be especially...
Background. Arterial stiffness (ASt) increases with age, a process accelerated by uraemia and reversed transplantation (Tx). Increased ASt results in an elevated pulse wave velocity (PWV). Methods. To compare the PWV of Tx patients ( n = 25, age 15.1/95% CI 13.5–16.7/year) healthy controls, three control groups were formed: matched for (A), height weight (H/W) (A/H), respectively. avoid bias from growth deficit Tx, firstly Z -scores calculated (PWV-Z). Second, PWV/height (PWV/h) ratio was...
Voice-sensitivity in the auditory cortex of a range mammals has been proposed to be determined primarily by tuning conspecific stimuli, but recent human findings indicate role for more general voicelikeness. Vocal emotional valence, central characteristic vocalisations, linked same basic acoustic parameters across species. Comparative neuroimaging revealed that during voice perception, such modulate valence-sensitivity cortical regions both family dogs and humans. To explore voicelikeness...
Mild cognitive impairment (MCI) refers to a measurable deficit in cognition the absence of dementia or activities daily living. Working memory is among earliest signs MCI. Oscillatory analysis working might be potential tool for identifying patients at increased risk developing dementia. Our study aimed assess temporospatial pattern spectral differences during maintenance between MCI and healthy controls compare sources oscillatory activity two groups. Event-related perturbation 17 21...
Former studies suggest that the core features of psychopathy, namely callous-unemotional (CU) traits are associated with emotional dysfunction characterized by atypical processing other people's distress. Using a dimensional approach to CU traits, current study aims test neural activity during performance facial expression recognition task in community sample young adults. Forty-one participants (25 females, M age = 25.44, SD 4.03) completed Inventory Callous-Unemotional Traits. Functional...
Anatomic variants of the circle Willis (CW) are commonly observed in healthy subjects. Genetic and environmental factors influencing these remain unclear. Our aim was to assess genetic background affecting variant CW phenotypes.A total 122 adult twins from Hungarian Twin Registry (39 monozygotic (MZ) 22 dizygotic (DZ) pairs, average age 49.7 ± 13.4 years) underwent Time-of-Flight magnetic resonance angiography transcranial Doppler sonography. We investigated anterior posterior according...
Abstract Background The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations this brain area have been found in migraine. In addition, altered serotonergic neurotransmission has repeatedly implicated pathophysiology migraine, although exact mechanism not known. Thus, our aim was to investigate relationship between acute increase serotonin (5-HT) level activation changes ACC using pharmacological challenge MRI (phMRI)...
Abstract Dysfunction of subcortical D2-like dopamine receptors (D 2 Rs) can lead to positive symptoms schizophrenia, and their analog, the increased locomotor activity in schizophrenia model MAM-E17 rats. The ventral pallidum (VP) is a limbic structure containing D Rs. R antagonist sulpiride widespread antipsychotic drug, which alleviate human patients. However, it still not known how influence via VP We hypothesize that microinjection into normalize hyperactivity In addition, recently, we...
Background and aimsCentral pulse wave velocity (PWV) is a marker of arterial stiffness calculated by dividing the travel distance transit time. However, there no consensus as to ideal measurement in children. The aim our study was identify more reliable method assess pediatric age.MethodsCarotid-femoral PWV measured applanation tonometry 988 healthy children aged 6.5–19.9 years. Two different surface distances were assessed: subtraction method, representing from suprasternal notch femoral...
Background and Objectives: Subcortical grey matter structures play essential roles in cognitive, affective, social, motoric functions humans. Their volume changes with age, decreased volumes have been linked many neuropsychiatric disorders. The aim of our study was to examine the heritability six subcortical brain (the amygdala, caudate nucleus, pallidum, putamen, thalamus, nucleus accumbens) four general total intra-cranial matter, white cerebrospinal fluid (CSF) volume) twins. Materials...
Schizophrenia has a negative effect on the activity of temporal and prefrontal cortices in processing emotional facial expressions. However no previous research focused evaluation mixed emotions schizophrenia, albeit they are frequently expressed everyday situations by expressions.Altogether 37 subjects, 19 patients with schizophrenia 18 healthy control subjects were enrolled study. The two study groups did not differ age education. stimulus set consisted 10 fearful (100%), happy fear (70%...