A5100739105- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Axon Guidance and Neuronal Signaling
- Cancer Research and Treatments
- Plant biochemistry and biosynthesis
- Autophagy in Disease and Therapy
- Phytochemistry and Biological Activities
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- Sesquiterpenes and Asteraceae Studies
- Ion Channels and Receptors
- Tannin, Tannase and Anticancer Activities
- Kruppel-like factors research
- Protein Degradation and Inhibitors
- Nanoplatforms for cancer theranostics
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
China Medical University
2020-2023
China Medical University Beigang Hospital
2020-2023
Fudan University
2023
Ganzhou People's Hospital
2018-2021
Zhuhai People's Hospital
2019-2021
Donghua University
2021
Shanxi Medical University
2008-2020
First Hospital of Shanxi Medical University
2008-2020
Jinan University
2019
Autophagy plays a vital role in hepatocellular carcinoma (HCC) pathogenesis. Long non-coding RNAs (lncRNAs) are considered regulators of autophagy, and the aim present study was to investigate prognostic value autophagy-related lncRNA (ARlncRNA) develop new signature predict 1-year 3-year overall survival (OS) HCC patients. Transcriptome clinical information patients obtained from The Cancer Genome Atlas database. A set ARlncRNAs identified by co-expression analysis, which seven (AC005229.4,...
Although immunotherapy has achieved great success in the treatment of a variety tumors, its efficacy for glioblastoma (GBM) is still limited. Both immunosuppressive tumor microenvironment (TME) and poor penetration immunotherapeutic agents into tumors contributed to anti-glioma immunity. Herein, we develop an injectable prodrug-loaded hydrogel delivery system with sono-activatable properties sonodynamic therapy (SDT)-triggered immunomodulation GBM treatment. The prodrug alginate hydrogels...
Gastrointestinal (GI) infection is evidenced with involvement in COVID-19 pathogenesis caused by SARS-CoV-2. However, the correlation between GI microbiota and distinct pathogenicity of SARS-CoV-2 Proto its emerging variants remains unclear. In this study, we aimed to determine if impacted effect varied variants. We performed an integrative analysis histopathology, microbiomics, transcriptomics on tract fragments from rhesus monkeys infected proto or Based degree pathological damage profile...
Doxorubicin (Dox) causes the generation of intracellular reactive oxygen species (ROS) and inactivates insulin-like growth factor 1 (IGF1) signaling, leading to cardiomyocyte apoptosis. IGF-binding protein 3 (IGFBP3) is most abundant circulating IGF1 carrier with high affinity, which has been reported mediate ROS-induced Hypoxia-inducible 1α (HIF1A), an upstream IGFBP3 regulated by prolyl hydroxylase domain (PHD) through hydroxylation. In this study, we investigated role IGFBP3, HIF1A, PHD...
Purpose: The biological functions of neuropilin and tolloid-like 2 (NETO2) in the progression pancreatic cancer remained unexplored. We aimed to investigate roles underlying molecular mechanisms NETO2 cancer. Materials methods: Thirty paired tumor tissue samples corresponding nontumor tissues were obtained from 30 patients who did not receive preoperative chemotherapy or radiotherapy. changes multiple cellular associated with assessed after knockdown/overexpression cell lines. Additionally,...
Three new bisdesmosidic saponins named conyzasaponins A, B, and C (1-3) one monodesmosidic saponin, conyzasaponin G (4), were isolated from the aerial parts of Conyza blinii. Their structures elucidated on basis extensive NMR (DEPT, DQF-COSY, HOHAHA, HMQC, HMBC, NOESY) MS studies. Compounds 1-3 share a common prosapogenin, bayogenin 3-O-beta-D-xylopyranosyl-(1-->3)-beta-D-glucopyranoside, which is identical with differ in ester-linked sugar moieties at C-28. Conyzasaponin A (1)...
A novel zwitterionic polysulfamide-based nanogel was developed with UCST-type thermo-responsiveness and salt-responsiveness, which showed surface regeneration ability controlled drug release.
Nine new triterpenoid saponins, conyzasaponins I−Q (1−9), were isolated from the aerial parts of Conyza blinii. Their structures established on basis extensive 1D and 2D NMR spectra as well by chemical degradations. Among these compounds, M−O (5−7) share a common pentasaccharide unit attached to C-28 aglycon, 28-O-β-d-apiofuranosyl-(1→3)-β-d-xylopyranosyl-(1→4)-[β-d-apiofuranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranosyl ester, which contains two apiofuranosyl residues. To best...
Non-small cell lung cancer (NSCLC) seriously endangers human health. Circular RNAs (circRNAs) regulate diverse types of cancers, including NSCLC. This study investigated the possible mechanism circ0001313 in NSCLC.Circ0001313 expression NSCLC tissues was measured, and its correlation with clinicopathological features analyzed. The binding relationships among circ0001313, microRNA (miR)-452 HMGB3 were tested. gain loss functions performed to examine malignant behaviors. After overexpression,...
Abstract Hyperglycemia results in the formation of reactive oxygen species which turn causes advanced glycation end products (AGEs) formation, leading to diabetic cardiomyopathy. Our previous study showed that AGE‐induced species‐dependent apoptosis is mediated via protein kinase C delta (PKCδ)‐enhanced mitochondrial damage cardiomyocytes. By using microRNA (miRNA) database, miRNA‐210 was predicted target c‐Jun N‐terminal (JNK), were previously identified as downstream PKCδ regulating...
Abstract Lung cancer is a leading cause of cancer‐related death worldwide. In this study, we used lung adenocarcinoma cells as model, has the highest mortality rate among all cancers. For past few years, medical treatments or have been limited because chemotherapy resistance. Therefore, understanding pathogenesis development drug resistance in urgent. Gemcitabine widely prescribed chemotherapeutic treatment developed gemcitabine‐resistant (A549‐GR) from A549 cell line. The results showed...
Abstract Aim The present study was conducted to determine whether two important signalling molecules of store‐operated channel (SOC), stromal interaction molecule 1 (STIM1) and Orai1, were involved in glomerular podocyte injury. We explored the effects STIM1/Orai1 overexpression on associated proteins cell permeability. Methods expression STIM1 Orai1 examined renal cortex adriamycin‐induced nephropathy mice by real‐time RT‐PCR. recombinant plasmid / , identified restriction enzyme digestion...
The present study aimed to identify the molecular mechanisms of microRNA‑124 (miRNA‑124/miR‑124) in hepatoblastoma. GSE6207 microarray dataset, obtained from Gene Expression Omnibus database, included samples extracted HepG2 cells transfected with miR‑124 duplex (the experimental group) or negative control at 4, 8, 16, 24, 32, 72 and 120 h after transfection. Differentially expressed genes (DEGs) were screened between two groups. activity was inferred based on expression its target genes....
The protein phosphatase 1 regulatory subunit 3 G (PPP1R3G) participates in many tumor biological processes; however, its effects on lung adenocarcinoma (LUAD) have not been clarified. Therefore, this study aimed to explore the correlation between PPP1R3G and prognosis immune invasion of LUAD. We evaluated relationship LUAD using a wide range databases analysis tools, including UALCAN, TIMER, miRDB, Human Protein Atlas MethSurv database. First, we explored mRNA expression levels LUAD, results...
Trichostatin A (TSA) is a well-known histone deacetylases (HDACs) inhibitor that has been reported to show potent anti-tumor capabilities in some types of cancer cell lines. However, detailed mechanism TSA action on lymphoma remains be described. In the present study, anti-proliferative effects were investigated using murine pro-B line FL5.12. MTT assay revealed potently inhibited proliferation FL5.12 cells time- and dose-dependent manner. Bright-field microscopy showed apoptotic morphology...
Objective To investigate the effect of epidermal growth factor receptor 2 (ErbB2) expression on invasion ofglioma cells and its possible mechanism.Methods Glioma TJ905 were cultured in vitro; ErbB2 shRNA overexpression vectors constructed transfected into T J905 to down-regulate up-regulate levels; empty vector plasmid was also as control group.Invasive ability changes measured by Transwell assay,and levels matrix metalloprotease (MMP)-2 MMP-9 identified Western blotting.Results As compared...