Background The correlations between the intra-renal resistive index (RRI) and renal histopathology characteristics, especially in those with infected allografts, have not been sufficiently investigated transplant recipients. We aimed to examine correlation RRI allograft infection these subjects.

Abstract Background Cardiorenal syndrome poses significant diagnostic and therapeutic challenges. The Venous Excess Ultrasound (VExUS) grading system based on the combination of venous Doppler assessments has shown potential in predicting acute kidney injury cardiovascular outcomes, but its relevance regarding management acutely decompensated heart failure (ADHF) remains to be fully understood. Methods In this prospective study, patients with ADHF (AKI) were enrolled from a medical intensive...

Aim We aim to describe the pattern of response treatment in a cohort Egyptian lupus nephritis (LN) patients and define variable prognostic factors. Methods retrospectively analyzed records 928 systemic erythematosus (SLE) (898 females, 30 males) with biopsy-confirmed LN seen between 2006 2012 at Cairo University hospitals. Results Our study involved SLE mean age 26.25 ± 6.487 years, duration time renal biopsy 6.48 4.27 months, SLEDAI 28.22 11.7, follow-up 44.14 17.34 months. Induction...

INTRODUCTION: Direct-acting antiviral agents (DAAs) have modified the management of chronic hepatitis C virus (HCV) infection, including HCV-related cryoglobulinemic vasculitis (CryoVas). However, patients might experience relapse, and no reliable predictors CryoVas relapse after sustained virologic response (SVR) been established. We aimed to describe HCV-CryoVas rates factors associated with it. METHODS: An international multicenter cohort where from Egypt, France, Italy treated DAA were...

Abstract Background Amelioration of proteinuria is one main treatment targets in patients with glomerulonephritis, yet the remission rates are suboptimal. Aim study To examine effect sodium–glucose transporter 2 inhibitor (empagliflozin) on and kidney function progression, glomerulonephritis not due to diabetic diseases. Subjects methods Fifty were recruited. The entry criteria diagnosis (proteinuria ≥ 500 mg⁄g) spite use maximal tolerated dose RAAS blocking agents together specific...

Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) evolving as most important link between MBD many pathologic sequences CKD. The aim was evaluate IR pre-dialysis CKD patients looking for possible association A total 100 stage 3–5 were selected beside 20 normal control subjects. Homeostatic model assessment...

Our study aimed to obtain a comprehensive review of the incidence biopsy-proven glomerulonephritis (GN) at Cairo University Hospitals, Egypt, over last five years. We analyzed clinical and pathological data all renal biopsy samples that were performed during period from July 2003 2008. Renal 924 patients referred for assessment [437 male 487 female patients; their mean age was 26.5 ± 14.6 years (range: 2.5-71 years)]. Focal segmental glomerulo-nephritis most frequent cause primary GN...

<b><i>Introduction:</i></b> The side effects profile of the new direct-­acting antivirals for treatment hepatitis C virus (HCV) is not fully elucidated. <b><i>Objective:</i></b> In this cross-sectional study, we aim to describe incidence and characteristics a novel observation de novo renal cryoglobulinemic glomerulonephritis after successful with DAA. <b><i>Methodology:</i></b> A total 12,985 Hepatitis Patients...

Therapeutic plasma exchange is used in treating different immunological and non-immunological diseases. We analyzed the outcome of 308 patients treated by 1783 membrane sessions from January 2011 until 2017 at Cairo University Hospital. Thrombotic microangiopathies were commonest indication [73 (23.7%) patients] with response 63/73 (86.3%), followed systemic vasculitis pulmonary-renal involvement [40(13%) recovery 32/40 (80.0%), Guillain-Barré syndrome [39(12.7%) 30/39 (76.9%), myasthenia...

Rheumatoid arthritis (RA) is accompanied by a variety of nephropathies. It often difficult to distinguish between disease-associated and drug-associated renal diseases. Three hundred seventy-six RA patients with involvement were included in our study; they subjected full history clinical examination, kidney function, 24-h urinary protein, biopsy. All on methotrexate, low dose steroids, nonsteroidal anti-inflammatory drugs, addition the previous medications. About 79.3%, 20.7%, 6.9%, 5.9%...

Currently, there is no available data about Vitamin D status among Egyptian chronic kidney disease (CKD) patients. This cross-sectional study looking for the prevalence of deficiency Stage 3a-5 CKD patients and its possible associations. We studied 1624 adults (689 males 935 females) together with 200 normal control persons. All recruited candidates were tested body mass index (BMI); serum levels blood urea nitrogen, creatinine, calcium (Ca), phosphorus (P), parathyroid hormone (PTH), 25...

Serum 25-hydroxyvitamin D (25(OH)D) negatively correlates with serum phosphorus level of stage 3a-5 chronic kidney disease (CKD) patients. So far, no explanation has been provided for this negative association.To confirm association and determine if relationship is mediated through other known co-morbid factors.One hundred (57 male 43 female) pre-dialysis CKD patients were selected. Estimated glomerular filtration rate (eGFR), calcium (Ca), (P), 25(OH)D, parathyroid hormone (PTH), intact...

Lupus nephritis (LN) is one of the most serious complications SLE. Tregs (Regulatory T lymphocytes) are thought to play a part in pathogenesis According recent research, Foxp3, Treg identification marker, plays significant role This study aimed compare urinary Foxp3 mRNA levels patients with active and inactive forms LN healthy control subjects see whether it played disease activity.We measured FOXP3 messenger RNA (mRNA) expression urine 50 people LN, lupus, people.We found that level was...

Background The incidence of subdural hematoma (SDH) in chronic maintenance hemodialysis (CMH) patients may change over time, along with the evolving characteristics underlying populations.Methods We conducted a retrospective, single-center study at Cairo University hospitals, assessing incidence, associated risk factors, and outcomes nontraumatic SDH CMH between January 2006 2019.Results Out 1217 patients, was diagnosed 41 (3.37%) during study, increasing enrollees' age but stable...

Many of the mineral metabolite abnormalities encountered in chronic kidney disease (CKD) patients were found also associated with acute injury (AKI). In last decade, sclerostin was to intimately affect bone metabolism CKD patients. Nothing is known about AKI. We looked for serum level AKI comparison normal control subjects and if there an impact on metabolic derangement, endothelial function or clinical outcome. This a cross sectional case observational study 219 cases (group I) beside age...

Background Patients with diabetic kidney disease (DKD) are at increased risk to develop post-contrast acute injury (AKI). Diabetic patients under dipeptidyl peptidase 4 inhibitors (DPP4Is) experience a lower propensity AKI. We speculated that linagliptin as single agent or in combination allopurinol may reduce the incidence of AKI stage 3–5 chronic (CKD) underlying DKD.Methods Out 951 DKD eligible for this study, 800 accepted sign informed consent. They were randomly allocated equal groups...

Sir, The incidence of biopsy-proven glomerulonephritis (GN) varies in different geographical areas and is affected by socio-economic conditions, race, differences genetic susceptibility environmental exposure. Recent studies suggested a changing pattern GN parts the world [1,2]. For instance, end-stage renal disease (ESRD) as result focal segmental glomerulosclerosis (FSGS) has increased 11-fold past two decades recent study [2]. Our aimed to obtain comprehensive review Cairo...