A5025491656- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Eating Disorders and Behaviors
- Dermatology and Skin Diseases
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Asthma and respiratory diseases
- SARS-CoV-2 detection and testing
- Eosinophilic Esophagitis
- Signaling Pathways in Disease
- Biosensors and Analytical Detection
- Gastrointestinal Tumor Research and Treatment
- Synthesis of Indole Derivatives
- Autoimmune and Inflammatory Disorders
- Genomics and Rare Diseases
- Homelessness and Social Issues
- Cancer-related cognitive impairment studies
- Forest Insect Ecology and Management
- Infant Nutrition and Health
- Fire effects on ecosystems
- Child Nutrition and Water Access
- Adrenal Hormones and Disorders
- Urticaria and Related Conditions
- Cancer survivorship and care
Population Health Research Institute
2021
St George's, University of London
2021
University of London
2021
University of California, San Francisco
2019-2020
Willamette Valley Cancer Foundation
2019
Valley Medical Center
2019
Tygerberg Hospital
2004
Stellenbosch University
2004
Northwick Park Hospital
1982-1983
BackgroundThe influence of early exposure to allergenic foods on the subsequent development food allergy remains uncertain.ObjectiveWe sought determine feasibility introduction multiple exclusively breast-fed infants from 3 months age and effect breastfeeding performance.MethodsWe performed a randomized controlled trial. The group (EIG) continued with sequential 6 foods: cow's milk, peanut, hard-boiled hen's egg, sesame, whitefish (cod), wheat; standard followed UK infant feeding...
The Enquiring About Tolerance (EAT) study was a randomized trial of the early introduction allergenic solids into infant diet from 3 months age. intervention effect did not reach statistical significance in intention-to-treat analysis primary outcome.We sought to determine whether infants at high risk developing food allergy benefited introduction.A secondary performed groups: nonwhite infants; with visible eczema enrollment, severity determined by SCORAD; and enrollment sensitization...
Food allergy is thought to develop through transcutaneous sensitization, especially in the presence of skin barrier impairment and inflammation. Regular moisturizer application infant could potentially promote sensitization development food allergy.We tested this hypothesis Enquiring About Tolerance (EAT) study population.The EAT was a population-based randomized clinical trial conducted from January 15, 2008, August 31, 2015, recruited 1303 exclusively breastfed 3-month-old infants their...
ABSTRACT The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due to the high rates transmission by individuals who are asymptomatic at time 1, . Frequent, widespread testing population for SARS-CoV-2 essential suppress viral transmission. Despite increases in capacity, multiple challenges remain deploying traditional reverse transcription and quantitative PCR (RT-qPCR) tests scale required screening individuals. We have developed SwabSeq, a high-throughput...
Innovative new crystallographic methods are facilitating structural studies from ever smaller crystals of biological macromolecules. In particular, serial X-ray crystallography and microcrystal electron diffraction (MicroED) have emerged as useful for obtaining information on the nanometre to micrometre scale. Despite utility these methods, their implementation can often be difficult, they present many challenges that not encountered in traditional macromolecular experiments. Here, XFEL...
BackgroundThe Enquiring About Tolerance (EAT) study examined whether the early introduction of 6 allergenic foods from 3 months age in exclusively breastfed infants prevented development food allergy. The intervention was effective per-protocol analysis for allergy to 1 or more and egg peanut individually, but only 42% group (EIG) children met criteria.ObjectiveWe sought identify which factors were responsible nonadherence EAT study.MethodsFactors influencing adherence within key period EIG...
Soybean lipoxygenase (SLO) has served as a prototype for understanding the molecular origin of enzymatic rate accelerations. The double mutant (DM) L546A/L754A is considered dramatic outlier, due to unprecedented size and near temperature-independence its primary kinetic isotope effect, low catalytic efficiency, elevated enthalpy activation. To uncover physical basis these features, we herein apply three structural probes: hydrogen–deuterium exchange mass spectrometry, room-temperature X-ray...
BackgroundThe early introduction group participants of the Enquiring About Tolerance study were asked to undertake a proscriptive regimen and sustained consumption 6 allergenic foods. It was envisaged that this might be challenging, families presented with an open-text question express any problems they experiencing in recurring online questionnaires.ObjectiveWe sought analyze these questionnaire responses aim identifying challenges associated regular foods.MethodsThree combinations interim...
The purpose of this case report cancer complicating Crohn's disease is to highlight the occult nature these tumours. From literature it apparent that majority are only discovered by pathologist. As many inconspicuous even on macroscopic examination an improved method dissection suggested.
Abdominal pain is a common symptom in systemic lupus erythematosus. We report two patients with recurrent severe attacks of abdominal pain, often necessitating hospital admission, which were not diagnosed until laparotomy. In one an active arteritis the mesenteric arteries was seen, infarction jejunum and ileum, second ileum haemorrhage conglutination red cells, but no true arteritis.
To measure functionality, symptoms, and quality of life in elderly patients, a geriatric oncology module (GOM) was developed that could be rapidly effectively administered community practices.The GOM validated by semi structured patient interviews. The authors tested 26 patients receiving chemotherapy with paclitaxel or plus carboplatin to determine the effect drug treatment on (QOL).Chemotherapy stabilized improved QOL 75%, 86%, 76% respectively. This easily implemented busy practice.Weekly...
Abstract Innovative new crystallographic methods are facilitating structural studies from ever smaller crystals of biological macromolecules. In particular, serial X-ray crystallography and microcrystal electron diffraction (MicroED) have emerged as useful for obtaining information on the nanometer to micron scale. Despite utility these methods, their implementation can often be difficult, they present many challenges not encountered in traditional macromolecular experiments. Here, we...
Journal Article Postoperative adrenal haemorrhage Get access E M Thompson, Thompson Northwick Park Hospital, Harrow, Middlesex Search for other works by this author on: Oxford Academic Google Scholar P W Skinner British of Surgery, Volume 70, Issue 7, July 1983, Pages 443–444, https://doi.org/10.1002/bjs.1800700719 Published: 07 December 2005 history Accepted: 29 April 1982