A5100330256- Toxic Organic Pollutants Impact
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Microbial bioremediation and biosurfactants
- Environmental remediation with nanomaterials
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Pesticide and Herbicide Environmental Studies
- Medicinal Plants and Bioactive Compounds
- International Maritime Law Issues
- Cancer, Hypoxia, and Metabolism
- Supramolecular Self-Assembly in Materials
- Flavonoids in Medical Research
- Studies on Chitinases and Chitosanases
- Flame retardant materials and properties
- Water Quality Monitoring and Analysis
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Jilin Jianzhu University
2021-2024
North China Electric Power University
2018-2024
Qingdao University of Science and Technology
2024
China National Environmental Monitoring Center
2020-2024
National Marine Environmental Monitoring Center
2020-2024
University of California, San Diego
2024
Sun Yat-sen University
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Abstract Understanding the mechanism of Na+/K+-dependent spectral conversion human telomeric G-quadruplex (G4) sequences has been limited not only because structural polymorphism but also lack sufficient information at different stages along process for one given oligonucleotide. In this work, we have determined topology Na+ form Tel23 G4, which is same hybrid as K+ G4 despite distinct patterns in their respective nuclear magnetic resonance (NMR) and circular dichroism spectra. The...
Viruses can inhabit their hosts in the form of an ensemble various mutant strains. Reconstructing a robust consensus representation for these diverse strains is essential recognizing genetic variations among and delving into aspects like virulence, pathogenesis, selecting therapies. Virus genomes are typically small, often composed only few thousand to several hundred nucleotides. While constructing high-quality virus might seem feasible, most current assemblers generated fragmented contigs....
The role of G-quadruplexes (G4s) in biological systems has been widely studied. It is found that they have an important function gene transcription and regulation. In this work, we identified two topologies hairpin G4 structures formed by a native G-rich sequence (WT22: 5'-GGGCCACCGGGCAGGGGGCGGG-3') from the WNT1 promoter region using nuclear magnetic resonance (NMR) spectroscopy. With help site-specific isotope labeling, these are unambiguously characterized. Circular dichroism NMR results...
Chromium contamination has been an increasing threat to the environment and human health. Cr(VI) Cr(III) are most common states of chromium. However, compared with Cr(III), is more toxic easily absorbed, therefore, it harmful beings. Thus, conversion into accepted strategy for chromium detoxification. Here, we isolated two Bacillus cereus strains a high tolerance reduction ability, named B. D 332, respectively. Both demonstrated strong pH temperature adaptability survival under 8 mM Cr(VI)....
The folding topology of DNA G-quadruplexes (G4s) depends not only on their nucleotide sequences but also environmental factors and/or ligand binding.Here, a G4 ligand, 3,6-bis(1-methyl-4-vinylpyridium iodide)-9-(1-(1-methyl-piperidinium iodide)-3,6,9trioxaundecane) carbazole (BMVC-8C3O), can induce topological conversion non-parallel to parallel forms in human telomeric G4s.Nuclear magnetic resonance (NMR) spectroscopy with hydrogen-deuterium exchange (HDX) reveals the presence persistent...
The treatment of non-small cell lung cancer (NSCLC) is challenging due to immune tolerance and evasion. Salidroside (SAL) an extract in traditional Chinese medicine has a potential antitumor effect. However, the mechanism SAL regulating immunological microenvironment NSCLC yet be clarified.The mouse model with Lewis line (3LL) C57BL/6 mice was established. And then, percentage tumor-infiltrating T subsets including Treg detected tumor-bearing or without treatment. In vitro, effect on...
DNA secondary structures and methylation are two well-known mechanisms that regulate gene expression. The catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), is overexpressed in ∼90% cancers to maintain telomere length for cell immortalization. Binding CCCTC-binding factor (CTCF) the first exon hTERT can down-regulate its However, prevent CTCF binding most cancers, but molecular mechanism unknown. NMR analysis showed a stretch guanine-rich sequence located within...
Abstract Background Gastric cancer (GC) is one of the most common malignant tumors digestive tract which seriously endangers health human beings worldwide. Transcriptomic deregulation by epigenetic mechanisms plays a crucial role in heterogeneous progression GC. This study aimed to investigate impact epigenetically regulated genes on prognosis, immune microenvironment, and potential treatment Results Under premise verifying significant co-regulation aberrant frequencies microRNA (miRNA)...
Abstract Heat shock proteins (HSPs) were known as the molecular chaperones, which play a pivotal role in protein quality control system, ensuring correct folding of proteins, and facilitating refolding damaged via transient interaction with their substrate proteins. They also practice regulation cell cycles are involved apoptosis. We found that HspB2 was almost completely silent pancreatic cancer few studies investigated cells, particularly cancer. Here, we reported effectively inhibited...
B-cell acute lymphocytic leukemia (B-ALL) is a malignant blood cancer that develops in children and adults leads to high mortality. THZ1, covalent cyclin-dependent kinase 7 (CDK7) inhibitor, shows anti-tumor effects various cancers by inhibiting cell proliferation inducing apoptosis. However, whether THZ1 has an inhibitory effect on B-ALL cells the underlying mechanism remains obscure. In this study, we showed arrested cycle of vitro low concentration, while apoptosis concentration...