A5088171420- Myasthenia Gravis and Thymoma
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Electrolyte and hormonal disorders
- COVID-19 and healthcare impacts
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Urticaria and Related Conditions
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Inorganic Chemistry and Materials
- Cutaneous Melanoma Detection and Management
- Lung Cancer Treatments and Mutations
- Pneumonia and Respiratory Infections
- Adrenal and Paraganglionic Tumors
- Bacterial Infections and Vaccines
- Radiopharmaceutical Chemistry and Applications
- Pathogenesis and Treatment of Hiccups
- Disaster Response and Management
- Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Vascular Tumors and Angiosarcomas
- Potassium and Related Disorders
Marche Polytechnic University
2014-2021
Azienda Ospedaliero Universitaria Ospedali Riuniti
2015-2021
Ospedali Riuniti Umberto I
2015-2020
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2015-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2017
After coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO, response from Italian Health System to react an unprecedented condition became necessary and sudden. The COVID-19 has required oncologists redefine clinical organization patient management. purpose of our study document difficulties emerging during SARS-CoV-2 in oncology.We broadcasted electronic survey oncologic health care professionals. It consisted 45 questions ranging individual perception management hospital...
Bordetella bronchiseptica (B.bronchiseptica) is a frequent cause of respiratory infections in animals but rarely causes serious infection humans. We present rare case B. pneumonia patient with lung cancer. A 52-year-old white male non small cell cancer developed fever during treatment nivolumab. persistent productive cough and deterioration his clinical condition led to hospitalization for evaluation. Bronchoscopy was performed diagnosis made. The successfully managed by antiobiotic therapy....
// Rossana Berardi 1 , Alessandro Brunelli 2 Silvia Pagliaretta Vittorio Paolucci Conti 4 Gaia Goteri 5 Majed Refai 3 Cecilia Pompili Giulia Marcantognini Francesca Morgese Zelmira Ballatore Agnese Savini Mariagrazia De Lisa Miriam Caramanti Matteo Santoni Antonio Zizzi Francesco Piva 6 Paola Mazzanti Azzurra Onofri Armando Sabbatini Marina Scarpelli Stefano Cascinu Medical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I – GM...
The aim of the study was to investigate Programmed cell Death protein 1 (PD-1) and Death-Ligand (PD-L1) their mRNA expression in thymic epithelial tumors (TETs).We analyzed 68 samples formalin-fixed paraffin-embedded tissue (63 thymomas 5 carcinomas). PD-1 PD-L1 were evaluated by immunohistochemistry, real-time PCR.M/F ratio 33/35, median age 60.5 years. Twenty patients had Myasthenia Gravis (MG). In subgroup with large (>5 cm), overexpression significantly associated worse prognosis vs. no...
Background In the United States, 80,000 cases of melanoma are expected in 2014, representing 5% and 4% all diagnosis cancer men women, respectively. Italy 2013, there were an estimated 10,500 cutaneous melanoma, with incidence 14.3 per 100,000 male population 13.6 female population. Female patients generally exhibit significantly longer survival than patients. The aim this study is to evaluate role gender relationship between pathologic features neoplasm.
Biliary tract cancers (BTC) include both gallbladder cancer and cholangiocarcinoma, of which have a poor prognosis. The aim our study was to evaluate the main clinical prognostic factors in this setting assess their impact on overall survival (OS).We retrospectively analyzed data collected 64 patients with BTC who underwent surgery radical intent at institution. OS estimated using Kaplan-Meier method. Cox regression model used perform univariate multivariate analyses.Preoperative...
Irinotecan-based regimens are used worldwide for the treatment of several recurrent or advanced gastrointestinal malignancies. In this paper we describe cases four patients treated in our institution who developed acute dysarthria while receiving intravenous infusion irinotecan. all cases, occurred during first course irinotecan, and then resolved rapidly without any sequelae. Imaging brain was performed, but failed to show evidence an neurological event. We also reviewed literature on very...
The role of tumor burden (TB) for patients with non-small cell lung cancer (NSCLC) receiving immunotherapy is still unknown. aim this analysis was to analyze the prognostic value TB in a real-world sample advanced NSCLC patients.Sixty-five consecutive treated as first or second line therapy were retrospectively analyzed between August 2015 and February 2018. recorded at baseline considering sites number metastases, thoracic vs. extrathoracic disease, measurable disease (MD) not-MD (NMD)...
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.
e13075 Background: BM are still the main cause of morbidity and morbility in cancer patients, mostly due to their complications defined as skeletal-related event (SRE). SRE reduce patients’quality life a serious health problem from clinical economical point view. The majority data concerning patients obtained retrospective experiences. aims collect prospective on natural history SREs, evaluate biological factors (as objective response, bone pain, biomarker value) related both primary tumors...
We previously showed that selected single-nucleotide-polymorphisms (SNPs) of genes involved in angiogenesis influence the aggressiveness thymic epithelial tumors (TETs). This study analyzes their role TETs and benign lesions, order to investigate potential correlation with risk outcome.Genomic DNA was extracted from paraffin-embedded tissue 92 patients, undergoing surgery at our Institution. investigated by Real-Time PCR SNPs following genes: platelet-derived growth factor receptor-α...
Abstract Background: Thymic Hyperplasia refers to an enlargement of the thymus, while thymomas display significant heterogeneity from morphologic point view, clinical behaviour, expression immunohistochemical markers and molecular profiling. Therefore improving our understanding biology thymic disorders represents a key challenge in treatment these rare diseases. Methods: The genomic DNA 93 consecutive patients undergoing total thymectomy at Institution was extracted paraffin-embedded...
e18557 Background: Thymomas (T) display heterogeneity from morphologic point of view, clinical behaviour, immunohistochemical markers and molecular profiling. Thus improving our understanding the biology thymic malignancies (TM) represents a key challenge in treatment these tumors. Methods: The genomic DNA 93 consecutive patients (pts) undergoing total thymectomy was extracted paraffin-embedded tissue. We studied following SNPs: HIF-1a (rs2057482T>C, rs1951795A>C, rs2301113C>A,...
Results: Sixty-six patients were enrolled, 50 male (75.8%) and 16 female (24.2%).Median age was 72 years (range 25-88).
Abstract Introduction: Since December 2019, coronavirus disease 2019 (COVID-19) has spread to every country, taking on pandemic proportions in few months. Physicians were asked redefine ordinary hospital organization, reprogramming clinically differentiable activities. Materials and Methods: During the COVID our Institution was supported by a call center (CC, named TOPS s.r.l.) make triage for cancer patients (pts) scheduled follow-up outpatient clinics: C1 (dedicated female tumors), C2 (for...