Mileni da Silva Fernandes

ORCID: 0000-0002-6125-6697
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About
Contact & Profiles
Research Areas
  • Fluoride Effects and Removal
  • Bone and Dental Protein Studies
  • Mercury impact and mitigation studies
  • Folate and B Vitamins Research
  • Anesthesia and Neurotoxicity Research
  • Bone Tissue Engineering Materials
  • Nutrition and Health in Aging
  • Environmental Toxicology and Ecotoxicology
  • Cystic Fibrosis Research Advances
  • Bone Metabolism and Diseases
  • Dental Implant Techniques and Outcomes
  • Oral microbiology and periodontitis research
  • Insect and Pesticide Research
  • Insect and Arachnid Ecology and Behavior
  • Heavy Metal Exposure and Toxicity
  • Alkaline Phosphatase Research Studies
  • Circadian rhythm and melatonin
  • Sepsis Diagnosis and Treatment
  • Heavy Metals in Plants
  • Bee Products Chemical Analysis
  • Facial Trauma and Fracture Management
  • Selenium in Biological Systems
  • Protease and Inhibitor Mechanisms
  • Orthopaedic implants and arthroplasty
  • Trace Elements in Health

Universidade de São Paulo
2005-2023

Louisiana State University Health Sciences Center New Orleans
2023

Fundação Faculdade de Odontologia
2021

Universidade Federal de São Carlos
2012-2018

Universidade Sagrado Coração
2012

Universidade Brasil
2011

Universidade do Extremo Sul Catarinense
2007

Universidade Federal da Bahia
2005

Abstract Understanding the effect of pesticides on survival honeybee colonies is important because these pollinators are reportedly declining globally. In present study, we examined changes in head proteome nurse honeybees exposed to individual and combined (the fungicide pyraclostrobin insecticide fipronil) at field-relevant doses (850 2.5 ppb, respectively). The proteomes bees were compared with those that not exposed, proteins differences expression identified by mass spectrometry....

10.1038/s41598-020-59070-8 article EN cc-by Scientific Reports 2020-02-10

The effect of chronic fluoride (F) exposure from the drinking water on parameters related to glucose homeostasis was investigated. Wistar rats were randomly distributed into 2 groups (diabetic [D] and nondiabetic [ND]; n = 54 each). In D, diabetes induced with streptozotocin. Each group further divided 3 subgroups (0, 10, or 50 mgF/L in water). After 22 days treatment, plasma liver samples collected. No alterations glycemia, insulinemia, K(ITT), HOMA2-IR (homeostasis model assessment insulin...

10.1177/0022034515581186 article EN Journal of Dental Research 2015-04-10

Ilex paraguariensis St Hilaire (Aquifoliaceae) is a plant widely cultivated in South America and with various reputed medicinal properties that can be attributed to phenolic constituents of the leaves: caffeine, theophylline theobromine, besides flavonoids, quercetin rutin. This study examined antiparkinsonian activity hydroalcohol extract models protection against cerebral injury induced by MPTP reversal catatonia reserpine mice. The prevented MPTP-induced hypolocomotion at doses 250 500...

10.1002/ptr.2166 article EN Phytotherapy Research 2007-05-08

Abstract The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored relationship between F concentrations bone plasma. Thirty male were randomised into three groups: Group I (No-F, No-Exercise), II (50 ppmF, III Exercise). Body weight physical performance all measured at baseline end experiment. plasma Mean concentration was significantly higher (p < 0.001) Groups compared with I. also 0.01) There a...

10.1038/s41598-018-21616-2 article EN cc-by Scientific Reports 2018-02-12

Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there some speculation that excess fluoride could cause an impact on genome integrity. In the current study, potential DNA damage associated with exposure to was assessed cells of blood, liver, kidney, thyroid gland and urinary bladder by single cell gel (comet) assay. Male Wistar rats aging 75 days were distributed into seven groups: Groups 1 (control), 2, 3, 4, 5, 6 7 received 0 (deionized water), 10, 20,...

10.1177/0960327107076288 article EN Human & Experimental Toxicology 2007-05-01

It is known that current trends on bone bioengineering seek ideal scaffolds and explore innovative methods to restore tissue function. In this way, the objective of study was evaluate behavior anorganic bovine as osteoblast carrier in critical-size calvarial defects. MC3T3-E1 cells (1x10(5) cells/well) were cultured granules 24-well plates after 24 h these implanted into rat defects (group Biomaterial + Cells). addition, other groups established with different fillings defect: Blood Clot...

10.1590/s0103-64402012000400002 article EN cc-by Brazilian Dental Journal 2012-01-01

A method has been developed for the direct determination of copper in petroleum condensate using detergentless micro-emulsions (three-component solutions) and graphite furnace atomic absorption spectrometry. The optimization was performed a three-level full factorial design, resulting pyrolysis atomization temperatures 920 °C 2600 °C, respectively. Using secondary line at 327.4 nm, which is less affected by magnetic field Zeeman-effect background correction system, characteristic mass 39 pg,...

10.1039/b414502j article EN Journal of Analytical Atomic Spectrometry 2005-01-01

The aim of this study was to compare the effect fluoride (F) on alkaline phosphatase activity in liver and plasma rats. Four groups male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F deionized (control) throughout experiment were included study. animals euthanized had their tissues blood collected for analysis phosphatase. There an increase concentration most treated with higher concentrations, except heart. assay showed concentrations (p<0.05). This suggested...

10.1590/s1516-89132011000600014 article EN cc-by-nc Brazilian Archives of Biology and Technology 2011-12-01

This study evaluated the kinetics of fluoride in plasma, femur surface and whole rats, after chronic exposure to different water levels was interrupted. Four groups Wistar rats received drinking containing 0, 5, 15 or 50 microg F/ml for 60 days (n = 50/group). The animals were euthanized immediately 7, 30, 90 180 10/subgroup). Plasma femurs collected. Fluoride on surface, plasma analyzed with an electrode. Data using ANOVA Tukey's test (p< 0.05). increase significant only group at 0 7 days....

10.1358/mf.2008.30.3.1161004 article EN Methods and Findings in Experimental and Clinical Pharmacology 2008-01-01

10.1016/j.cbpa.2005.09.011 article EN Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology 2005-11-30

Background Pulmonary sequelae (PS) in patients with chronic paracoccidioidomycosis (PCM) typically include pulmonary fibrosis and emphysema. Knowledge of the molecular pathways involved PS PCM is required for treatment biomarker identification. Methodology/Principal findings This non-concurrent cohort study included 29 that were followed before after treatment. From this group, 17 evolved to mild/ moderate 12 severe PS. Sera from evaluated at clinical cure, serological apparent cure. A...

10.1371/journal.pntd.0009714 article EN cc-by PLoS neglected tropical diseases 2021-08-23

The aim of this study was to evaluate comparatively the effect fluoride (F) on activity matrix metalloproteinases 2 and 9 (MMP-2 MMP-9) involved in process alveolar bone repair. Material methods: This used 4 groups Wistar rats with 80 days life (n = 160) which received drinking water containing different doses (NaF): 5, 15, 50 ppm deionized (control) throughout experiment. These animals had their right upper incisors extracted. After extraction, were euthanized at 7, 14, 21 30 hemi-maxillae...

10.21726/rsbo.v9i3.994 article EN RSBO 2013-09-30

We compared the parameters related to glucose homeostasis, and liver muscle proteomes in fluorosis-susceptible (A/J; S) fluorosis-resistant (129P3/J; R) mice response fluoride (F) exposure exercise. Ninety male (45 R-mice 45 S-mice) were randomized into three groups: (SI; RI) No-F, No-Exercise, (SII; RII) 50 ppm F, (SIII; RIII) Exercise. Overall, mean F concentrations plasma femur significantly higher with S-mice. In R-mice, exercise resulted an increase accumulation femur. S-mice, level was...

10.3390/metabo12020117 article EN cc-by Metabolites 2022-01-25
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