A5032944680- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
- Mosquito-borne diseases and control
- Antimicrobial Peptides and Activities
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Malaria Research and Control
- Immunotherapy and Immune Responses
- SARS-CoV-2 detection and testing
- Immunodeficiency and Autoimmune Disorders
- COVID-19 and healthcare impacts
- vaccines and immunoinformatics approaches
- Disaster Response and Management
- Immune responses and vaccinations
- Dermatological and COVID-19 studies
- Cytokine Signaling Pathways and Interactions
Institute of Life Sciences
2018-2023
Regional Centre for Biotechnology
2021-2023
Indian Institute of Information Technology Design and Manufacturing Jabalpur
2022
HCG Cancer Hospital
2020
Systemic lupus erythematous (SLE) is a chronic autoimmune disorder, broadly characterized by systemic inflammation along with heterogeneous clinical manifestations, severe morbidity, moribund organ failure and eventual mortality. In our study, SLE patients displayed higher percentage of activated, inflamed hyper-polarized CD8+ T cells, dysregulated cell differentiation, significantly elevated serum inflammatory cytokines accumulation cellular ROS when compared to healthy controls....
Purpose The current global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), led to the investigation with clinical, biochemical, immunological, and genomic characterization from patients understand pathophysiology viral infection. Methods Samples were collected six asymptomatic symptomatic SARS-CoV-2-confirmed hospitalized in Bhubaneswar, Odisha, India. Clinical details, biochemical parameters, treatment regimen a hospital; load was...
The response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely impacted by the level of virus exposure and status host immunity. nature protection shown direct asymptomatic contacts disease 2019 (COVID-19)-positive patients quite intriguing. In this study, we have characterized antibody titer, SARS-CoV-2 surrogate neutralization, cytokine levels, single-cell T-cell receptor (TCR), B-cell (BCR) profiling in contacts, infected cases, controls. We observed significant...
Infections caused by the Zika virus (ZIKV) have detrimental effects on human health, in particular infants. As no potent drug or vaccine is available to date contain this viral disease, it necessary design inhibitors that can target NS2B-NS3 protease of ZIKV, which mainly responsible for proliferation inside host cells . Here, molecular dynamics (MD) simulation and mechanics energies combined with generalized Born surface area continuum solvation model (MM/GBSA) are used understand binding...
CD4+ T cells are critically involved in the pathogenesis of Rheumatoid Arthritis; an autoimmune disorder characterized by joint inflammation and bone degeneration. In this study, we focused on critical role cytokines, IL-21 IL-23 facilitating aberrant status RA Th17-like report their significant contribution(s) modulating expression inflammatory cytokines RANKL.Blood synovial fluid collected from a total 167 patients 25 healthy volunteers were assessed for various markers RANKL plasma cells....
The lethality of blood stage P.berghei ANKA (PbA) infection is associated with the expression T-bet and production cytokine IFN-γ. Expression Inducible costimulator (ICOS) its downstream signaling has been shown to play a critical role in IFN-γ production. Although earlier studies have examined ICOS control acute blood-stage P. chabaudi AS (a non-lethal model malaria infection), significance lethal PbA remains unclear. Thus, address seminal infection, we treated infected mice anti-ICOS...
The ongoing COVID-19 (SARS-CoV-2) pandemic has affected the lives of people in more than 190 countries (almost entire globe) a short span 4 months.[1] As we come to terms with its far reaching implications, there is also clear and present danger 262,366 randomized clinical trials, as listed on clinicaltrial.gov.[2] This not just recruitment immediate patient care, but for data collection analysis follow-in medium long term.
Background SARS-CoV2 infection in patients with comorbidities, particularly T2DM, has been a major challenge globally and shown to be associated high morbidity mortality. Here, we did whole blood immunophenotyping along plasma cytokine, chemokine, antibody isotyping, viral load from oropharyngeal swab understand the immune pathology T2DM infected SARS-CoV2. Methods Blood samples 25 Covid-19 positive having 10 not negative, non-diabetic healthy controls were assessed for various cells by...
Background: The current global pandemic of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 led to the investigation with clinical, biochemical, immunological and genomic characterization from patients understand pathophysiology viral infection.Methods: Samples were collected six asymptomatic symptomatic confirmed hospitalized in Bhubaneswar, Odisha, India. Clinical details, biochemical parameters, treatment regime hospital, load was determined RT-PCR, levels cytokines circulating...
Abstract The role of CD4 + T cells specifically, Th17 has been well documented in RA pathogenesis. Here we focus on the critical cytokines IL-21 and IL-23 facilitating aberrant status Th17-like report their significant contribution(s) modulating expression inflammatory RANKL. Neutralizing or IL- 23 (p19 p40) both, resulted downregulation cytokines, TNF-α, IFN-γ 17 RANKL cells. Our ex vivo human studies also validated above findings hypothesize a common pathway responsible for regulation...
SARS-CoV2 infection has caused an increase in mortality and morbidity but with vaccination, the disease severity significantly reduced. But emergence of various variants concerns (VOCs), vaccine breakthrough also increased. Here, we studied circulating spike specific T follicular response (cTfh) naïve vaccinees convalescent (individuals who got delta after 2 doses BBV152 vaccine) to understand their as they are most crucial cells that involve mediated protection by helping B-cell maturation....
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐Cov2) infection has caused an increase in mortality and morbidity, but with vaccination, the disease severity significantly reduced. With emergence of various variants concern (VOCs), vaccine breakthrough also increased. Here we studied circulating spike‐specific T follicular response (cTfh) infection‐naïve vaccinees convalescent (individuals who got Delta after two doses BBV152 vaccine) to understand their as they are most...
Abstract Systemic Lupus Erythematous (SLE) is a chronic autoimmune disorder, broadly characterized by systemic inflammation along with heterogeneous clinical manifestations, severe morbidity, moribund organ failure and eventual mortality. In our study, SLE patients displayed higher percentage of activated, inflamed hyper polarized CD8 + T cells, dysregulated cell differentiation, significantly elevated serum inflammatory cytokines, accumulation cellular ROS when compared to healthy controls....
Abstract The response to SARS-CoV-2 is largely impacted by the level of exposure and status immunity. nature protection shown direct contacts COVID-19 positive patients quite intriguing note. We aimed study immune differences reinforcing contact individuals in circumventing disease. Our observation showed PCR developed elevated neutralizing antibody titres cytokine levels. On other hand, single cell data revealed differential usage V(D)J genes unique BCR clonotypes imparting protective...
Summary Background The current global pandemic of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 led to the investigation with clinical, biochemical, immunological and genomic characterization from patients understand pathophysiology viral infection. Methods Samples were collected six asymptomatic symptomatic confirmed hospitalized in Bhubaneswar, Odisha, India. Clinical details, biochemical parameters, treatment regime hospital, load was determined RT-PCR, levels cytokines...
Abstract Background SARS-CoV2 infection in patients with comorbidities, particularly T2DM has been a major challenge globally. Here, we did whole blood immunophenotyping along plasma cytokine, chemokine, antibody isotyping and viral load determination from oropharyngeal swab to understand the immune pathology infected SARS-CoV2. Methods Blood samples 25 Covid-19 positive having T2DM, 10 not negative, non-diabetic healthy controls were assessed for various cells by analyzing their signature...